Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Usuk Jung"'
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma
Autor:
Erdong Wei, Ana Mitanoska, Quinn O’Brien, Kendall Porter, MacKenzie Molina, Haseeb Ahsan, Usuk Jung, Lauren Mills, Michael Kyba, Darko Bosnakovski
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-22 (2024)
Abstract Ewing sarcoma (ES) poses a significant therapeutic challenge due to the difficulty in targeting its main oncodriver, EWS::FLI1. We show that pharmacological targeting of the EWS::FLI1 transcriptional complex via inhibition of P300/CBP drives
Externí odkaz:
https://doaj.org/article/3923b7e698e143889b1d963ad608e92e
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Genetic selection for high growth rate, breast muscle yield, and feed efficiency in modern broilers has been a double-edged sword. While it has resulted in marked benefits in production, it has also introduced widespread incidence of breast muscle my
Externí odkaz:
https://doaj.org/article/08ab45b425ce40a0be217384f7e70bb1
Autor:
Usuk Jung, Minjeong Kim, Presley Dowker-Key, Simon Noë, Ahmed Bettaieb, Elizabeth Shepherd, Brynn Voy
Publikováno v:
Poultry Science, Vol 103, Iss 1, Pp 103203- (2024)
ABSTRACT: Breast muscle myopathies in broilers compromise meat quality and continue to plague the poultry industry. Broiler breast muscle myopathies are characterized by impaired satellite cell (SC)-mediated repair, and localized tissue hypoxia and d
Externí odkaz:
https://doaj.org/article/5a97c09aee7a4ecea1a6a975c27fdb61
Publikováno v:
Journal of Animal Science and Technology, Vol 64, Iss 2, Pp 330-342 (2022)
We aimed to investigate candidate proteins related to long-term caloric restriction and feed efficiency in bovine longissimus dorsi muscle (LM). A total of 31 Korean native steers were randomly distributed to ad libitum (n = 16) or caloric restric
Externí odkaz:
https://doaj.org/article/0daa7c126995456bb789b832f048200c
Publikováno v:
Antioxidants, Vol 10, Iss 1, p 35 (2020)
Lipid metabolism in avian species places unique demands on the liver in comparison to most mammals. The avian liver synthesizes the vast majority of fatty acids that provide energy and support cell membrane synthesis throughout the bird. Egg producti
Externí odkaz:
https://doaj.org/article/b72d5620adfc436bbe8f2002095a24de
Publikováno v:
Journal of Animal Science. 100
Development and maintenance of healthy muscle fibers rely on the myogenic potential of satellite cells (SC), muscle stem cells that proliferate and differentiate to form myotubes. Satellite cells are indispensable for post-hatch muscle growth as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4369fcc3aba028766ba778266419458f
https://doi.org/10.1093/jas/skac342
https://doi.org/10.1093/jas/skac342
Publikováno v:
Journal of Visualized Experiments.
Primary preadipocytes are a valuable experimental system for understanding the molecular pathways that control adipocyte differentiation and metabolism. Chicken embryos provide the opportunity to isolate preadipocytes from the earliest stage of adipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4905d8c9dc53d55df0aca25bbb71148d
https://doi.org/10.3791/63861
https://doi.org/10.3791/63861
Autor:
Sun Hwa Park, Heekyung Park, Chanchal Mandal, William G. Stetler-Stevenson, Min-Jung Kang, Junseo Oh, Young-Sik Kim, Usuk Jung, Ji Wook Moon, Soovin Lee
Publikováno v:
The American journal of pathology. 191(12)
Transdifferentiation (or activation) of hepatic stellate cells (HSCs) to myofibroblasts is a key event in liver fibrosis, and activated HSCs in tumor microenvironment reportedly promote tumor progression. This study aimed to analyze the effect of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacc0cf8608d14830d9210d93160b012
https://pubmed.ncbi.nlm.nih.gov/34428424
https://pubmed.ncbi.nlm.nih.gov/34428424
Publikováno v:
J Anim Sci
The objective of this work was to establish protocols for isolating, maintaining, and differentiating SCs from broiler embryos and young chicks so that this model can be used to identify factors that affect myogenic development. Efficient production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc62df6666ad55476a7dc828cc652cd
https://doi.org/10.1093/jas/skab235.668
https://doi.org/10.1093/jas/skab235.668
Publikováno v:
Antioxidants
Antioxidants, Vol 10, Iss 35, p 35 (2021)
Antioxidants, Vol 10, Iss 35, p 35 (2021)
Lipid metabolism in avian species places unique demands on the liver in comparison to most mammals. The avian liver synthesizes the vast majority of fatty acids that provide energy and support cell membrane synthesis throughout the bird. Egg producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d4984009305a78f238647ae9972cb7
https://doi.org/10.3390/antiox10010035
https://doi.org/10.3390/antiox10010035