The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Autor: Wingerd JS; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Mozar CA; Discipline of Pharmacology, University of Sydney, Camperdown, NSW, 2006, Australia., Ussing CA; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.; Novo Nordisk A/S, Copenhagen Area, Capital Region, Denmark., Murali SS; Discipline of Pharmacology, University of Sydney, Camperdown, NSW, 2006, Australia.; Harvard Medical School, Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, United States., Chin YK; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Cristofori-Armstrong B; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Durek T; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Gilchrist J; Department of Physiology and Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA., Vaughan CW; Pain Management Research Institute, University of Sydney, St Leonards, NSW, 2006, Australia., Bosmans F; Department of Physiology and Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA., Adams DJ; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia., Lewis RJ; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Alewood PF; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia., Mobli M; Centre for Advanced Imaging & School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, 4072, Australia., Christie MJ; Discipline of Pharmacology, University of Sydney, Camperdown, NSW, 2006, Australia., Rash LD; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia. l.rash@uq.edu.au.; School of Biomedical Sciences, The University of Queensland, St Lucia, 4072, QLD, Australia. l.rash@uq.edu.au.

Publikováno v: Scientific reports [Sci Rep] 2017 Apr 20; Vol. 7 (1), pp. 974. Date of Electronic Publication: 2017 Apr 20.