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Akademický článek

Cascade Hydroxyl Radical-Generating and Ferroptosis-Inducing Nanofiber System for the Therapy of Oral Squamous Cell Carcinoma

Autor: JiHye Park, Qiaojun Hao, Da In Jeong, Hyun-Jin Kim, Sungyun Kim, Song Yi Lee, Seongnam Chu, Usok Hyun, Hyun-Jong Cho

Publikováno v: Molecules, Vol 29, Iss 16, p 3964 (2024)

Nanofiber (NF) membrane systems that can provide cascade catalytic reaction and ferroptosis induction were developed for oral cancer therapy. Glucose oxidase (GOx) and aminoferrocene (AF) were introduced into the NF system for glucose deprivation/H2O

Externí odkaz: https://doaj.org/article/a8dfccaa564848f895a8fd525bd0046e

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Minimal size of prototype foamy virus integrase for nuclear localization

Autor: D H Lee, Usok Hyun, C G Shin

Publikováno v: Acta virologica. 55(2)

We have reported previously that the prototype foamy virus (PFV) integrase (IN) has a strong nuclear localization signal (NLS) in its C-terminal domain, in particular in a region of aa 306-334 including highly karyophilic arginines or lysines at posi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb230499af974bd0ff22bb3b59166a2a
https://pubmed.ncbi.nlm.nih.gov/21692567

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Characterization of biochemical properties of feline foamy virus integrase

Autor: Cha-Gyun Shin, Donghyun Lee, Ji-Ye Kim, Usok Hyun

Publikováno v: Journal of microbiology and biotechnology. 20(6)

In order to study biochemical properties, the integrase (IN) protein of feline foamy virus (FFV) was over-expressed from Escherichia coli, purified by two-step chromatography; Talon column and heparin column, and characterized in biochemical aspects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c964f43aa7613e85fa4f30835b64b9de
https://pubmed.ncbi.nlm.nih.gov/20622493

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Characterization of nuclear localization signals of the prototype foamy virus integrase

Autor: Dog Gn An, Usok Hyun, Cha-Gyun Shin

Publikováno v: The Journal of general virology. 89(Pt 7)

To analyse the potential karyophilic activity of prototype foamy viruses (PFVs), we expressed the PFV integrase (IN) and its mutants as fusion proteins with enhanced green fluorescence protein. The subcellular localization of the fusion proteins was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a86cdf40781c2f78d7bcfb5b637ffcb
https://pubmed.ncbi.nlm.nih.gov/18559938

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