Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen

Autor: Greene, Warner, Usmani, SM, Zirafi, O, Müller, JA, Sandi-Monroy, NL, Yadav, JK, Meier, C, Weil, T, Roan, NR, Greene, WC, Walther, P

Publikováno v: Greene, Warner; Usmani, SM; Zirafi, O; Müller, JA; Sandi-Monroy, NL; Yadav, JK; et al.(2014). Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8kk4s93m

Naturally occurring fragments of the abundant semen proteins prostatic acid phosphatase (PAP) and semenogelins form amyloid fibrils in vitro. These fibrils boost HIV infection and may play a key role in the spread of the AIDS pandemic. However, the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d908a513118173451a2df4464c55d1b1
http://www.escholarship.org/uc/item/8kk4s93m

Targeting the CBM complex causes T reg cells to prime tumours for immune checkpoint therapy.

Autor: Di Pilato M; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA. mdipilato@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. mdipilato@mgh.harvard.edu., Kim EY; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cadilha BL; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Prüßmann JN; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Nasrallah MN; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Seruggia D; Harvard Medical School, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Usmani SM; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Misale S; Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Zappulli V; Department of Comparative Biomedicine and Food Science, University of Padua, Padova, Italy., Carrizosa E; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Mani V; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Ligorio M; Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Warner RD; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Medoff BD; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Marangoni F; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Villani AC; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Mempel TR; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA. tmempel@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. tmempel@mgh.harvard.edu.

Publikováno v: Nature [Nature] 2019 Jun; Vol. 570 (7759), pp. 112-116. Date of Electronic Publication: 2019 May 15.

Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss.

Autor: Raynaud-Messina B; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31400 Toulouse Cedex 4, France; raynaud@ipbs.fr maridono@ipbs.fr verollet@ipbs.fr.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 31000 Toulouse, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 1425 Buenos Aires, Argentina., Bracq L; INSERM U1016, Institut Cochin, 75014 Paris, France.; CNRS UMR8104, Université Paris Descartes, 75006 Paris, France.; Institut Pasteur Shanghai, Chinese Academy of Sciences, 200000 Shanghai, China., Dupont M; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31400 Toulouse Cedex 4, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 31000 Toulouse, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 1425 Buenos Aires, Argentina.; Institute of Experimental Medicine-Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, National Academy of Medicine, 1425 Buenos Aires, Argentina., Souriant S; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31400 Toulouse Cedex 4, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 31000 Toulouse, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 1425 Buenos Aires, Argentina., Usmani SM; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129.; Harvard Medical School, Boston, MA 02115., Proag A; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31400 Toulouse Cedex 4, France., Pingris K; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31400 Toulouse Cedex 4, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 31000 Toulouse, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 1425 Buenos Aires, Argentina., Soldan V; Multiscale Electron Imaging Platform, 31062 Toulouse, France., Thibault C; Laboratory for Analysis and Architecture of Systems, CNRS, 31400 Toulouse, France.; Institut National des Sciences Appliquées de Toulouse, Université de Toulouse, 31400 Toulouse, France., Capilla F; INSERM, Université Paul Sabatier, École Nationale Vétérinaire de Toulouse, Centre Régional d'Exploration Fonctionnelle et de Ressources Expérimentales, Service d'Histopathologie, 31000 Toulouse Cedex 3, France., Al Saati T; INSERM, Université Paul Sabatier, École Nationale Vétérinaire de Toulouse, Centre Régional d'Exploration Fonctionnelle et de Ressources Expérimentales, Service d'Histopathologie, 31000 Toulouse Cedex 3, France., Gennero I; Centre de Physiopathologie de Toulouse-Purpan, INSERM-CNRS UMR 1043, Université Paul Sabatier, 31062 Toulouse, France.; Institut Fédératif de Biologie, Centre Hospitalier Universitaire Toulouse, 31059 Toulouse, France., Jurdic P; Institut de Génomique Fonctionnelle de Lyon, CNRS UMR3444, Université de Lyon, Ecole Normale Supérieure de Lyon, 69007 Lyon, France., Jolicoeur P; Division of Experimental Medicine, McGill University, Montreal, QC H3G 1A4, Canada.; Department of Microbiology and Immunology, University of Montreal, Montreal, QC H3T IJ4, Canada.; Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Montreal, QC H2W 1R7, Canada., Davignon JL; INSERM, Université Paul Sabatier, École Nationale Vétérinaire de Toulouse, Centre Régional d'Exploration Fonctionnelle et de Ressources Expérimentales, Service d'Histopathologie, 31000 Toulouse Cedex 3, France.; Centre de Physiopathologie de Toulouse-Purpan, INSERM-CNRS UMR 1043, Université Paul Sabatier, 31062 Toulouse, France., Mempel TR; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129.; Harvard Medical School, Boston, MA 02115., Benichou S; INSERM U1016, Institut Cochin, 75014 Paris, France.; CNRS UMR8104, Université Paris Descartes, 75006 Paris, France.; Institut Pasteur Shanghai, Chinese Academy of Sciences, 200000 Shanghai, China., Maridonneau-Parini I; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31400 Toulouse Cedex 4, France; raynaud@ipbs.fr maridono@ipbs.fr verollet@ipbs.fr.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 31000 Toulouse, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 1425 Buenos Aires, Argentina., Vérollet C; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31400 Toulouse Cedex 4, France; raynaud@ipbs.fr maridono@ipbs.fr verollet@ipbs.fr.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 31000 Toulouse, France.; International Associated Laboratory, CNRS 'Immuno-Metabolism-Macrophages-Tuberculosis/HIV' (1167), 1425 Buenos Aires, Argentina.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Mar 13; Vol. 115 (11), pp. E2556-E2565. Date of Electronic Publication: 2018 Feb 20.

Semen amyloids participate in spermatozoa selection and clearance.

Autor: Roan NR; Department or Urology, University of California San Francisco, San Francisco, United States.; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States., Sandi-Monroy N; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.; Kinderwunsch-Zentrum, Ulm, Germany., Kohgadai N; Department or Urology, University of California San Francisco, San Francisco, United States.; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States., Usmani SM; The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, United States., Hamil KG; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, United States., Neidleman J; Department or Urology, University of California San Francisco, San Francisco, United States.; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States., Montano M; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States., Ständker L; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.; Core Facility Functional Peptidomics, Ulm University, Ulm, Germany., Röcker A; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Cavrois M; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States.; Department of Medicine, University of California San Francisco, San Francisco, United States., Rosen J; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, United States., Marson K; HIV / AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, United States., Smith JF; Department or Urology, University of California San Francisco, San Francisco, United States., Pilcher CD; HIV / AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, United States., Gagsteiger F; Kinderwunsch-Zentrum, Ulm, Germany., Sakk O; Core Facility Transgenic Mice, Medical Faculty, Ulm University, Ulm, Germany., O'Rand M; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, United States., Lishko PV; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, United States., Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Münch J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Greene WC; Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, United States.; Department of Medicine, University of California San Francisco, San Francisco, United States.; Department of Microbiology and Immunology, University of California, San Francisco, United States.

Publikováno v: ELife [Elife] 2017 Jun 27; Vol. 6. Date of Electronic Publication: 2017 Jun 27.

Lentiviral Nef proteins manipulate T cells in a subset-specific manner.

Autor: Yu H; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Khalid M; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Heigele A; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Schmökel J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Usmani SM; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., van der Merwe J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Münch J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Silvestri G; Yerkes National Primate Research Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA., Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany frank.kirchhoff@uni-ulm.de.

Publikováno v: Journal of virology [J Virol] 2015 Feb; Vol. 89 (4), pp. 1986-2001. Date of Electronic Publication: 2014 Dec 10.