Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Usman Shabon"'
Autor:
Karen A. Simon-Crevatis, Shailesh R. Metkar, Justin T. Hardcastle, Keith Jansson, Usman Shabon, Rajarshi Choudhury, Euan A. Stronach, Kevin G. Coleman, Asli Muvaffak
Publikováno v:
Cancer Research. 83:6175-6175
While cyclin dependent kinases (CDKs) were originally implicated in cell cycle regulation, several CDKs including CDK7, CDK8, and CDK9 play critical roles in transcription through regulation of RNA polymerase II (Pol II) activity. In addition to expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5a84d1ec42e305a931c904608fbcac
https://doi.org/10.1158/1538-7445.am2023-6175
https://doi.org/10.1158/1538-7445.am2023-6175
Autor:
Coco Dong, Junping Jing, Benjamin Schwartz, David G. Cooper, Mugdha Khaladkar, Stefanie Riesenberg, Sarah A. Middleton, Yanhua Rao, Boris Wilson, Usman Shabon, Euan Stronach
Publikováno v:
Cancer Research. 78:2344-2344
Although most canonical somatic cancer mutations have now been cataloged, only a fraction are amenable to drug discovery efforts. These are limited to targets with gain of function mutations and druggable protein domains. Examples include kinases suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4294641800ebffa000c776605dd71391
https://doi.org/10.1158/1538-7445.am2018-2344
https://doi.org/10.1158/1538-7445.am2018-2344
Autor:
Douglas G. Johns, Bao W, Green P, Daniels Da, Nambi V. Aiyar, Behm Dj, Andrew J. Brown, Alastair Morrison, Simon J. Dowell, Zhaohui Ao, Walker Dj, Riddick M, Yue Tl, Staton Pc, Ellen M. Shapland, Stephen A. Douglas, Usman Shabon
Publikováno v:
British Journal of Pharmacology. 152:825-831
Background and purpose: Atypical cannabinoids are thought to cause vasodilatation through an as-yet unidentified ‘CBx' receptor. Recent reports suggest GPR55 is an atypical cannabinoid receptor, making it a candidate for the vasodilator ‘CBx' rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::883c44c88d627141ecd784d1b6ddb627
https://doi.org/10.1038/sj.bjp.0707419
https://doi.org/10.1038/sj.bjp.0707419
Autor:
Robert S. Ames, Parvathi Nuthulaganti, Jim A. Fornwald, Usman Shabon, Harjeet K. van-der-Keyl, Nabil A. Elshourbagy
Publikováno v:
Receptors and Channels. 10:117-124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8351ada95427edae2c695c173faee3f2
https://doi.org/10.3109/10606820490515012
https://doi.org/10.3109/10606820490515012
Autor:
Nambi Aiyar, Beverly E. Maleeff, Usman Shabon, Diane Naselsky, Zhaohui Ao, Stephen M. Harrison, Jyoti Disa, Stephen A. Douglas, Graham Duddy, Nabil Elshourbagy, Jan L. Sechler
Publikováno v:
British Journal of Pharmacology. 136:9-22
Urotensin-II (U-II) and its receptor (UT) represent novel therapeutic targets for management of a variety of cardiovascular diseases. To test such hypothesis, it will be necessary to develop experimental animal models for the manipulation of U-II/UT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f83a8f55fadf3bbd88d021892c8412e
https://doi.org/10.1038/sj.bjp.0704671
https://doi.org/10.1038/sj.bjp.0704671
Autor:
Jon K. Chambers, Laura R. Fitzgerald, Shelagh Wilson, Philip G. Szekeres, Nabil Elshourbagy, Usman Shabon, Dulcie B. Schmidt, George M. Dytko, Nicholas A. Evans, Derk J. Bergsma, Robert S. Ames, Kong B. Tan, Henry M. Sarau, Da Yuan Wang, Graeme Milligan, D. Alex Groarke, Peter T. Buckley, Paul R. Murdock, James J. Foley, Parvathi Nuthulaganti
Publikováno v:
Journal of Biological Chemistry. 275:25965-25971
Opiate tolerance and dependence are major clinical and social problems. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain modulation as well as in opioid tolerance and may play a critical role in this process, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5cafd790b16038f625a65339c455f1
https://doi.org/10.1074/jbc.m004515200
https://doi.org/10.1074/jbc.m004515200
Autor:
Anne M. Romanic, Douglas W. P. Hay, Shelagh Wilson, Eliot H. Ohlstein, Nambi Aiyar, Calvert Louden, Wu-Schyong Liu, Henry M. Sarau, George I. Glover, Stephen A. Douglas, Stephen Dudley Holmes, Charles F. Sauermelch, Nabil Elshourbagy, Usman Shabon, John D. Martin, Robert W. Coatney, James J. Foley, Johathan K. Chambers, Derk J. Bergsma, Catherine E. Ellis, Dean E. McNulty, Robert S. Ames, John J. Trill, Zhaohui Ao, Robert N. Willette, Jeffrey M. Stadel, Jyoti Disa
Publikováno v:
Nature. 401:282-286
Urotensin-II (U-II) is a vasoactive ‘somatostatin-like’ cyclic peptide which was originally isolated from fish spinal cords1,2, and which has recently been cloned from man3. Here we describe the identification of an orphan human G-protein-coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6f6a769e8aa255ebc1716ff22de776
https://doi.org/10.1038/45809
https://doi.org/10.1038/45809
Autor:
Philip G. Szekeres, Jim J. Hagan, Klaudia Steplewski, Nabil Elshourbagy, Shelagh Wilson, Declan N.C. Jones, David Michalovich, Tracey Ashmeade, Paul R. Murdock, Abdel Ennaceur, Mark S. Duxon, Mark Pullen, Cathy Ellis, Alan R. Atkins, Jane Gartlon, A. Jackie Hunter, Usman Shabon, Nambi Aiyar, Henry M. Sarau, Christian Heidbreder, David C. Harrison
Rationale: Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a33d44a40c1538447a9bdf533f7c75
Autor:
Robert, Ames, Parvathi, Nuthulaganti, Jim, Fornwald, Usman, Shabon, Harjeet, van-der-Keyl, Nabil, Elshourbagy
Publikováno v:
Receptorschannels. 10(3-4)
Recombinant baculoviruses, in which the insect cell-specific polyhedrin promoter has been replaced with a mammalian cell-active expression cassette (BacMam viruses), are efficient gene delivery vehicles for many mammalian cell types. BacMam viruses h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c05a01a2508616bbd6248833d1c531c8
https://pubmed.ncbi.nlm.nih.gov/15512846
https://pubmed.ncbi.nlm.nih.gov/15512846
Autor:
William E. Wixted, Peter T. Buckley, Appelbaum Edward Robert, Usman Shabon, James J. Foley, Philip G. Szekeres, Jyoti Disa, Mark Pullen, Nabil Elshourbagy, Henry M. Sarau, Jane Bolaky, Nambi Aiyar, Edward Dul
Publikováno v:
Pharmacology. 72(1)
Neuromedin U (NmU) is a smooth muscle contracting peptide. Recently, two G-protein-coupled receptors for NmU (NmU1R and NmU2R) have been cloned having approximately 50% homology. They have distinct patterns of expression suggesting they may have diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c55555de4ac213d42b6a4d497712248
https://pubmed.ncbi.nlm.nih.gov/15292653
https://pubmed.ncbi.nlm.nih.gov/15292653