Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Usha Warrior"'
Autor:
Sujatha M. Gopalakrishnan, Jens Halvard Grønlien, David J. Burns, John Malysz, Usha Warrior, Betsy M. Philip, David J. Anderson, Murali Gopalakrishnan
Publikováno v:
ASSAY and Drug Development Technologies. 9:635-645
α7 nicotinic acetylcholine receptors (nAChRs) are characterized by relatively low ACh sensitivity, rapid activation, and fast desensitization kinetics. ACh/agonist evoked currents at the α7 nAChR are transient, and, typically, calcium flux response
Autor:
Mai-Ha Bui, Nirupama B. Soni, Jennifer B. Donnelly, Eric F. Johnson, Keith B. Glaser, Zehan Chen, Sujatha M. Gopalakrishnan, Usha Warrior
Publikováno v:
Journal of Biological Chemistry. 286:43951-43958
Eukaryotic elongation factor-2 kinase (eEF2K) relays growth and stress signals to protein synthesis through phosphorylation and inactivation of eukaryotic elongation factor 2 (eEF2). 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) is a widely acc
Autor:
Natiya E. Robinson, Alyssa M. Croff, Vanessa L. Norman, Alastair J. King, Brogan A. Epkins, Lee R. Cavedine, Steven M. Garner, Jesse J. Parry, Kristin C. Dempsey, Charles R. Wageman, Usha Warrior
Publikováno v:
Cancer Research. 78:2260-2260
Using drug response data, generated by the OncoPanelTM cell-based profiling service, we investigated the differences between traditional and normalized growth rate inhibition (GR) metrics in drug sensitivity classification and predictive genomic biom
Autor:
Usha Warrior, Timothy J. Sindelar, Natiya E. Robinson, Vanessa L. Norman, Kristin C. Dempsey, Brogan A. Epkins, Alastair J. King, Charles R. Wageman, Lee R. Cavedine, Steven M. Garner, Jesse J. Parry, Alyssa M. Croff
Publikováno v:
Cancer Research. 78:1391-1391
Given the importance and significance of targeting mutations and epigenetic modification in cancer therapy, we sought to expand on our ability to test drugs with epigenetic modulatory abilities by increasing the exposure time of drugs against cell li
Publikováno v:
Molecular Cancer Therapeutics. 17:B068-B068
Introduction and Relevance: We have developed an in vitro cellular functional STING pathway assay that can be used to screen for potential therapeutic agents in drug discovery. Stimulator of interferon genes (STING, or TMEM173) is an endoplasmic reti
Autor:
Sujatha M. Gopalakrishnan, Mark E. Schurdak, Nicole Teusch, Usha Warrior, David J. Burns, Margot H. M. Bakker, Christiane Imhof
Publikováno v:
Journal of Neuroscience Research. 86:2214-2226
Activation of the Rho kinase (ROCK) pathway has been associated with inhibition of neurite regeneration and outgrowth in spinal cord injury. Growth-inhibitory substances present in the glial scar such as chondroitin sulfate proteoglycans (CSPGs) have
Publikováno v:
SLAS Discovery. 13:527-537
Prioritization of compounds based on human hepatotoxicity potential is currently a key unmet need in drug discovery, as it can become a major problem for several lead compounds in later stages of the drug discovery pipeline. The authors report the va
Autor:
Usha Warrior, Stephen W. Fesik, Michael R. Michaelides, Navdeep S. Chandel, Frank Weinberg, Jennifer B. Donnelly, Xiaoyu Lin, Kathryn V. Tormos, Caroline A. David, Yu Shen, Xiaoli Huang
Publikováno v:
Proceedings of the National Academy of Sciences. 105:174-179
Hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development and progression by regulating genes that are vital for proliferation, glycolysis, angiogenesis, and metastasis. To identify strategies of targeting the HIF-1 pathway, we
Publikováno v:
SLAS Discovery. 12:938-945
A 384-well soft agar assay was developed to identify potential novel anticancer compounds. Normally used to detect cell transformation, the assay is used here to quantitate cell proliferation in a 3-dimensional (3-D) anchorage-independent format. HCC
Autor:
Warren M. Kati, Rakesh Tripathi, Danli L. Towne, Jennifer B. Donnelly, Tim Middleton, Kevin A. Kurtz, John T. Randolph, Peggy P. Huang, Alex K. Konstantinidis, Usha Warrior, Paul L. Richardson, Chih-Ming Chen
Publikováno v:
Analytical Biochemistry. 368:156-167
Maturation of the hepatitis C virus (HCV) polyprotein occurs by a series of proteolytic processes catalyzed by host cell proteases and the virally encoded proteases NS2 and NS3. Although several peptidomimetic inhibitors of NS3 protease have been pub