Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Usha Prabhu"'
Autor:
Usha Prabhu, Alma N. Guerra, Paul J. Bertics, Zachary A. Pfeiffer, Monica L. Gavala, Mini Aga, David J. Hall, Lindsay M. Hill
Publikováno v:
Free Radical Biology and Medicine. 42:1506-1516
Macrophage activation is critical in the innate immune response and can be regulated by the nucleotide receptor P2X 7 . In this regard, P2X 7 signaling is not well understood but has been implicated in controlling reactive oxygen species (ROS) genera
Publikováno v:
Protein Expression and Purification. 51:283-292
Sigma receptors once considered as a class of opioid receptors are now regarded as unique orphan receptors, distinguished by the ability to bind various pharmacological agents such as the progesterone (steroid), haloperidol (anti-psychotic), and drug
Autor:
Arturo G. Guadarrama, Kirk J. Hogan, Giuditta Angelini, Dawn N. Green, Usha Prabhu, Loren C. Denlinger, Kathleen Schell, Paul J. Bertics, Douglas B. Coursin
Publikováno v:
The Journal of Immunology. 174:4424-4431
The nucleotide receptor P2X7 is expressed by most leukocytes and initiates signaling events that amplify numerous LPS responses. We tested the hypothesis that loss-of-function polymorphisms in the human P2X7 gene predispose to the production of an an
Publikováno v:
Journal of Leukocyte Biology. 75:1173-1182
Extracellular nucleotides regulate macrophage function via P2X nucleotide receptors that form ligand-gated ion channels. In particular, P2X7 activation is characterized by pore formation, membrane blebbing, and cytokine release. P2X7 is also linked t
Autor:
Usha Prabhu, Paul J. Bertics, Kirk J. Hogan, Loren C. Denlinger, Giuditta Angelini, Douglas B. Coursin, Dawn N. Green, Arturo G. Guadarrama, Kathleen Schell
Publikováno v:
Journal of Endotoxin Research. 10:137-142
The importance of accessory signaling pathways amplifying endotoxin responses has recently been highlighted by genetic studies describing LPS-hyporesponsive individuals despite carrying the common allele for TLR4. The nucleotide receptor P2X7 modulat
Autor:
Loren C. Denlinger, Kathleen Schell, Giuditta Angelini, Dawn Green, Arturo Guadarrama, Usha Prabhu, Douglas B. Coursin, Kirk Hogan, Paul J. Bertics
Publikováno v:
Journal of Endotoxin Research. 10:137-142
Autor:
Zachary A. Pfeiffer, Alma N. Guerra, Usha Prabhu, Jyoti J. Watters, Paul J. Bertics, Julie A. Sommer
Publikováno v:
Journal of Biological Chemistry. 277:9077-9087
Endotoxin (lipopolysaccharide, LPS) is a component of the outer membrane of Gram-negative bacteria and promotes the activation of macrophages and microglia. Although these cells are highly LPS-responsive, they serve unique tissue-specific functions a
Autor:
Loren C. Denlinger, Usha Prabhu, Alma N. Guerra, Philip L. Fisette, Jyoti J. Watters, Zachary A. Pfeiffer, Mini Aga, Paul J. Bertics, Julie A. Sommer
Publikováno v:
Drug Development Research. 53:91-104
During infection or inflammation, high concentrations of extracellular nucleotides are released into the inflammatory microenvironment, supplying a source of ligand for purinergic receptors that are present on many immune cell types. The P2X 7 recept
Autor:
Paul J. Bertics, Kathleen Schell, Jennifer Halsey, Loren C. Denlinger, Kirk J. Hogan, Dawn N. Green, Giuditta Angelini, Arturo G. Guadarrama, Usha Prabhu, Douglas B. Coursin
Publikováno v:
Clinical chemistry. 52(6)
Background: Innate immune response amplification is achieved by leukocyte expression of the purinergic nucleotide receptor P2X7, an extracellular nucleotide-gated pore. Previously, low P2X7 pore activity in whole blood was associated with loss-of-fun
Autor:
Zachary A. Pfeiffer, Julie A. Sommer, Arturo G. Guadarrama, Beatriz H. Quinchia-Rios, Usha Prabhu, Richard A. Proctor, Sara Abozeid, Loren C. Denlinger, Alma N. Guerra, Paul J. Bertics, Philip L. Fisette, Mini Aga
Publikováno v:
Journal of endotoxin research. 9(4)
Macrophages express several lipopolysaccharide (LPS) binding proteins and are potently activated by LPS to produce inflammatory mediators. Recent studies have shown that receptors for exogenous nucleotides (P2X and P2Y purinergic receptors) can modul