Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Usha Ponnappan"'
Publikováno v:
Biomolecules, Vol 5, Iss 1, Pp 95-112 (2015)
Alternative redox stimuli such as pervanadate or hypoxia/reoxygenation, induce transcription factor NF-κB by phospho-tyrosine-dependent and proteasome-independent mechanisms. While considerable attention has been paid to the absence of proteasomal r
Externí odkaz:
https://doaj.org/article/c4c2a74f7c0e44b7a03d83744f1ce7de
Autor:
Marco Demaria, Aimin Meng, Daohong Zhou, Jianhui Chang, Nukhet Aykin-Burns, Yingying Wang, Norman E. Sharpless, Lijian Shao, Yi Luo, Sheng Ding, Judith Campisi, Krishnamurthy Janakiraman, Xiaoyan Wang, Wei Feng, Remi-Martin Laberge, Usha Ponnappan, Martin Hauer-Jensen, Kimberly J. Krager
Publikováno v:
Nature Medicine. 22:78-83
Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI). Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders, suggesting that SCs play a ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c86c19552956c7882f5e4e55b3a5dd5
https://doi.org/10.1038/nm.4010
https://doi.org/10.1038/nm.4010
Publikováno v:
Aging Cell. 11:651-658
Chemokine-dependent migration of T lymphocytes assures recirculation of naive T cells to secondary lymphoid organs and tissue-specific trafficking of memory-effector T cells. Previous studies carried out in rodents have demonstrated age-associated mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73cc2478486c986e3e52a3ac9570642c
https://doi.org/10.1111/j.1474-9726.2012.00830.x
https://doi.org/10.1111/j.1474-9726.2012.00830.x
Publikováno v:
Cellular & Molecular Immunology. 9:86-96
Physiological aging imposes significant alterations in the repertoire of T cells and all associated functions. Although several studies have reported defects upon antigen-induced activation of T cells during aging, the molecular mechanisms that contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcdcd2ab5ba27c30dfae1af83f938bb
https://doi.org/10.1038/cmi.2011.41
https://doi.org/10.1038/cmi.2011.41
Publikováno v:
Biochemical Pharmacology. 79:706-714
Proteasome inhibition has become synonymous with inhibition of NF-kappaB activity. However, hyperactive NF-kappaB responses often accompany physiological conditions marked by proteasomal defects, i.e. advancing age, geriatric diseases, and bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bc9ab6b07f3bc024b1e831d3812307
https://doi.org/10.1016/j.bcp.2009.10.006
https://doi.org/10.1016/j.bcp.2009.10.006
Publikováno v:
Molecular Immunology. 47:600-605
The induction of key pro-inflammatory genes is regulated by the SWI/SNF class of ATP-dependent remodeling complexes. In particular, the catalytic ATPase subunit, Brg1, is distinctly involved in the chromatin remodeling required for activating pro-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a98831cf3be91f5acfb319258875850
https://doi.org/10.1016/j.molimm.2009.09.008
https://doi.org/10.1016/j.molimm.2009.09.008
Publikováno v:
Glycoconjugate Journal. 27:13-25
Nitric oxide (NO) is a signaling and defense molecule of major importance. NO endows macrophages with bactericidal, cytostatic as well as cytotoxic activity against various pathogens. Bacillus spores can produce serious diseases, which might be atten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa16ec42cf98f6130371bff8d9b2b9f
https://doi.org/10.1007/s10719-009-9248-7
https://doi.org/10.1007/s10719-009-9248-7
Autor:
Khaled Machaca, Usha Ponnappan, Claude Prigent, Shirley Haun, Angus M. MacNicol, Amanda Charlesworth, Rawad Hodeify, Subramaniam Ponnappan, Lu Sun
Publikováno v:
Biology of Reproduction. 78:726-735
In contrast to the well-defined role of Ca 2+ signals during mitosis, the contribution of Ca 2+ signaling to meiosis progression is controversial, despite several decades of investigating the role of Ca 2+ and its effectors in vertebrate oocyte matur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f622364cc6bc239dbb9735da6a2669fc
https://doi.org/10.1095/biolreprod.107.063693
https://doi.org/10.1095/biolreprod.107.063693
Publikováno v:
Free Radical Biology and Medicine. 42:541-551
Proteasome is a major cellular organelle responsible for the regulated turnover of both normal and misfolded proteins. Recent reports from our laboratory have implicated lowered proteasomal chymotryptic activity to be responsible for decreased induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf522155b21913e8b4a7828f65f8b020
https://doi.org/10.1016/j.freeradbiomed.2006.11.020
https://doi.org/10.1016/j.freeradbiomed.2006.11.020
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 39:799-809
Aging, in the immune system, is characterized by a decreased ability to respond to exogenous insults, resulting in increased susceptibility to infections and blunted response to vaccination. While significant age-associated deficits in immune functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fdbfbfce432224c3083defbd30a029
https://doi.org/10.1016/j.biocel.2007.01.002
https://doi.org/10.1016/j.biocel.2007.01.002