Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Usha P Andley"'
Autor:
Ariel M Alperstein, Kathleen S Molnar, Sidney S Dicke, Kieran M Farrell, Leah N Makley, Martin T Zanni, Usha P Andley
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257098 (2021)
αB-crystallin is a small heat shock protein that forms a heterooligomeric complex with αA-crystallin in the ocular lens. It is also widely distributed in tissues throughout the body and has been linked with neurodegenerative diseases such as Alzhei
Externí odkaz:
https://doaj.org/article/4c2942701ef94b0dad0b814255bade00
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0238081 (2020)
Cataracts are a major cause of blindness worldwide and commonly occur in individuals over 70 years old. Cataracts can also appear earlier in life due to genetic mutations. The lens proteins, αA- and αB-crystallins, are chaperone proteins that have
Externí odkaz:
https://doaj.org/article/5ce078972c0542d5beb34af4c94b22d9
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190817 (2018)
The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life. The structura
Externí odkaz:
https://doaj.org/article/5fab3fb3577a4ec7b1ec4b52d0640cdd
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95507 (2014)
αA-crystallin and αB-crystallin are members of the small heat shock protein family and function as molecular chaperones and major lens structural proteins. Although numerous studies have examined their chaperone-like activities in vitro, little is
Externí odkaz:
https://doaj.org/article/8de34269720e4a72810dd66f794e07cc
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17671 (2011)
An autosomal dominant missense mutation in αB-crystallin (αB-R120G) causes cataracts and desmin-related myopathy, but the underlying mechanisms are unknown. Here, we report the development of an αB-R120G crystallin knock-in mouse model of these di
Externí odkaz:
https://doaj.org/article/96b01e4b9d2943aeb12b4ffb138ed527
Autor:
Kehao, Wang, Masato, Hoshino, Kentaro, Uesugi, Naoto, Yagi, Barbara K, Pierscionek, Usha P, Andley
Purpose: To investigate how cataract-linked mutations affect the gradient refractive index (GRIN) and lens opacification in mouse lenses and whether there is any effect on the optics of the lens from treatment with an oxysterol compound.\ud \ud Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22046a083a5a7f79e8fa190006ef985e
https://arro.anglia.ac.uk/id/eprint/707533/1/Wang_2022.pdf
https://arro.anglia.ac.uk/id/eprint/707533/1/Wang_2022.pdf
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)
BMC Research Notes
BMC Research Notes
Objective Understanding the mechanisms of cataract formation is important for age-related and hereditary cataracts caused by mutations in lens protein genes. Lens proteins of the crystallin gene families α-, β-, and γ-crystallin are the most abund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bf5042685e496efc2565550a2eaada
http://link.springer.com/article/10.1186/s13104-020-05154-7
http://link.springer.com/article/10.1186/s13104-020-05154-7
ObjectiveTwo experimental samples from a mouse line containing Cryaa or Cryab modifications on a predominantly C57Bl/6 background using 129Sv mouse strain embryonic stem cells were investigated. The objective was to reexamine the precise genetic back
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97d7d7af102d97ba1b7157a58a800898
https://doi.org/10.1101/2020.10.16.343186
https://doi.org/10.1101/2020.10.16.343186
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0238081 (2020)
PLoS ONE, Vol 15, Iss 8, p e0238081 (2020)
Cataracts are a major cause of blindness worldwide and commonly occur in individuals over 70 years old. Cataracts can also appear earlier in life due to genetic mutations. The lens proteins, αA- and αB-crystallins, are chaperone proteins that have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef0b801b36931242f770ac84eca79e4
https://pubmed.ncbi.nlm.nih.gov/33216808
https://pubmed.ncbi.nlm.nih.gov/33216808
Autor:
Usha P. Andley, Paul D. Hamilton
Publikováno v:
Biochemistry and Biophysics Reports, Vol 15, Iss, Pp 7-12 (2018)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
The aggregation of crystallins in lenses is associated with cataract formation. We previously reported that mutant crystallins are associated with an increased abundance of histones in knock-in and knockout mouse models. However, very little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d50d6bbc78f0493001ac9280afefc8
https://doi.org/10.1016/j.bbrep.2018.05.005
https://doi.org/10.1016/j.bbrep.2018.05.005