Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Usha MacGarvey"'
Autor:
Samuel D. Rabkin, Susan Varghese, Usha MacGarvey, Robert L. Martuza, Renbin Liu, G. Petur Nielsen
Publikováno v:
Cancer Research. 67:9371-9379
Oncolytic viruses are an innovative therapeutic strategy for cancer, wherein viral replication and cytotoxicity are selective for tumor cells. Here we show the efficacy of systemically administered oncolytic viruses for the treatment of spontaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f33567bb68a41bab72328326d23bbb0
https://doi.org/10.1158/0008-5472.can-07-0674
https://doi.org/10.1158/0008-5472.can-07-0674
Autor:
Leslie A. Shinobu, Bowling Ac, Robert H. Brown, M. J. Baik, Usha MacGarvey, Robert J. Ferrante, M F Beal, Neil W. Kowall, Susan E. Browne
Publikováno v:
Journal of Neurochemistry. 69:2064-2074
Some cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS) are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1), suggesting that oxidative damage may play a role in ALS pathogenesis. To further inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f41b246f9baf1d6837f830523628ba
https://doi.org/10.1046/j.1471-4159.1997.69052064.x
https://doi.org/10.1046/j.1471-4159.1997.69052064.x
Autor:
Bowling Ac, Susan E. Browne, S. C. Berger, M F Beal, Miratul M. K. Muqit, Usha MacGarvey, M. J. Baik, Edward D. Bird
Publikováno v:
Annals of Neurology. 41:646-653
The etiology of the selective neuronal death that occurs in Huntington's disease (HD) is unknown. Several lines of evidence implicate the involvement of energetic defects and oxidative damage in the disease process, including a recent study that demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93a08a4efb0216eca6ac1cb1988c42a
https://doi.org/10.1002/ana.410410514
https://doi.org/10.1002/ana.410410514
Publikováno v:
Annals of Neurology. 28:157-161
A depletion of large cholinergic neurons in the nucleus basalis of Meynert is a consistent finding in Alzheimer's disease (AD). The nucleus basalis of Meynert also contains interneurons and afferents that may modulate its functioning. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd049c4e1849776f6b14640d9b165203
https://doi.org/10.1002/ana.410280207
https://doi.org/10.1002/ana.410280207
Autor:
Umberto Senin, Stefania Fulle, Giorgio Fanò, Patrizia Mecocci, Usha MacGarvey, Jacopo Vecchiet, M. Flint Beal, Antonio Cherubini, M. Cristina Polidori, Leslie A. Shinobu
A role for oxidative damage in normal aging is supported by studies in experimental animals, but there is limited evidence in man. We examined markers of oxidative damage to DNA, lipids, and proteins in 66 muscle biopsy specimens from humans aged 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8892e8511cfa5b152af25356bc7080c2
http://hdl.handle.net/11391/151114
http://hdl.handle.net/11391/151114
Publikováno v:
Annals of neurology. 36(5)
Oxidative damage to DNA may play a role in both normal aging and in neurodegenerative diseases. We examined whether Alzheimer's disease (AD) is associated with increased oxidative damage to nDNA and mtDNA in postmortem brain tissue. We measured the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee40b18fed7c03b2a2cc31308cdf75fc
https://pubmed.ncbi.nlm.nih.gov/7979220
https://pubmed.ncbi.nlm.nih.gov/7979220
Autor:
M F Beal, Deborah A. Koontz, John M. Shoffner, Douglas C. Wallace, Usha MacGarvey, Allan Kaufman, Patrizia Mecocci
Publikováno v:
Annals of neurology. 34(4)
A major theory of aging is that oxidative damage may accumulate in DNA and contribute to physiological changes associated with aging. We examined age-related accumulation of oxidative damage to both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56a4d80b6d5a279efb4fc1c67842396
https://pubmed.ncbi.nlm.nih.gov/8215249
https://pubmed.ncbi.nlm.nih.gov/8215249
Publikováno v:
Neuroscience letters. 146(1)
Kynurenic acid (KYA) is the only known endogenous excitatory amino acid antagonist in mammalian brain. In the present study we examined the effects of precursor loading with kynurenine (KYN) and blockade of organic acid transport with probenecid, eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee0c71baf30290b11d318996edc29b7
https://pubmed.ncbi.nlm.nih.gov/1475044
https://pubmed.ncbi.nlm.nih.gov/1475044
Publikováno v:
Brain research bulletin. 28(2)
Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain. Kynurenine administered intraperitoneally (150, 450, 900 mg/kg) 2 h before pentylenetetrazol injection dose-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee1c739e075bf5a53ceac7f47a1b009
https://pubmed.ncbi.nlm.nih.gov/1596743
https://pubmed.ncbi.nlm.nih.gov/1596743
Publikováno v:
Analytical biochemistry. 185(2)
Kynurenic acid is a broad-spectrum excitatory amino acid (EAA) receptor antagonist which is present in the mammalian central nervous system. We describe a method for the measurement of kynurenic acid using isocratic reverse-phase high-performance liq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd96b16838233bdb17492d3fce669f3c
https://pubmed.ncbi.nlm.nih.gov/2339792
https://pubmed.ncbi.nlm.nih.gov/2339792