Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Usha D. Hemraz"'
Autor:
Bassel Akache, Tyler M. Renner, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Christian Gervais, Jennifer J. Hill, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Anne E. G. Lenferink, Yves Durocher, Michael J. McCluskie
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-7 (2022)
Abstract Using our strongly immunogenic SmT1 SARS-CoV-2 spike antigen platform, we developed antigens based on the Beta & Delta variants of concern (VOC). These antigens elicited higher neutralizing antibody activity to the corresponding variant than
Externí odkaz:
https://doaj.org/article/d6403fda9ca74d4599cc113bbc9a49d9
Autor:
Tyler M. Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J. Hill, Usha D. Hemraz, Sophie Régnier, Anne E. G. Lenferink, Yves Durocher, Michael J. McCluskie
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Liposomes composed of sulfated lactosyl archaeol (SLA) have been shown to be a safe and effective vaccine adjuvant with a multitude of antigens in preclinical studies. In particular, SLA-adjuvanted SARS-CoV-2 subunit vaccines based on trimeric spike
Externí odkaz:
https://doaj.org/article/7fefd380ab0e4f5e85bdc7345e2dcf2c
Autor:
Bassel Akache, Tyler M. Renner, Anh Tran, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Diana Duque, Julie Haukenfrers, Martin A. Rossotti, Francis Gaudreault, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Wangxue Chen, Christian Gervais, Matthew Stuible, Lakshmi Krishnan, Yves Durocher, Michael J. McCluskie
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The huge worldwide demand for vaccines targeting SARS-CoV-2 has necessitated the continued development of novel improved formulations capable of reducing the burden of the COVID-19 pandemic. Herein, we evaluated novel protein subunit vaccine
Externí odkaz:
https://doaj.org/article/9618e29b6e8e4f74b75065bea762626c
Autor:
Bassel Akache, Andrew J. Read, Renu Dudani, Blair A. Harrison, Dean Williams, Lise Deschatelets, Yimei Jia, Vandana Chandan, Felicity C. Stark, Gerard Agbayani, Shawn R. Makinen, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Wei Zou, Peter D. Kirkland, Michael J. McCluskie
Publikováno v:
Vaccines, Vol 11, Iss 6, p 1043 (2023)
Vaccines play an important role in maintaining human and animal health worldwide. There is continued demand for effective and safe adjuvants capable of enhancing antigen-specific responses to a target pathogen. Rabbit hemorrhagic disease virus (RHDV)
Externí odkaz:
https://doaj.org/article/8033a136f9c84c7da76024c305c13447
Autor:
Gerard Agbayani, Yimei Jia, Bassel Akache, Vandana Chandan, Umar Iqbal, Felicity C. Stark, Lise Deschatelets, Edmond Lam, Usha D. Hemraz, Sophie Régnier, Lakshmi Krishnan, Michael J. McCluskie
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 9, Pp 2183-2195 (2020)
Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific
Externí odkaz:
https://doaj.org/article/3e7ef0b9480d48b5baae17d096234b45
Autor:
Jae-Young Cho, Pankaj Bhowmik, Patricia L. Polowick, Sabine G. Dodard, Mounir El-Bakkari, Goska Nowak, Hicham Fenniri, Usha D. Hemraz
Publikováno v:
ACS Omega, Vol 5, Iss 38, Pp 24422-24433 (2020)
Externí odkaz:
https://doaj.org/article/2286c96c9cd5496b8250eedc565e6b6c
Autor:
Edmond Lam, Usha D. Hemraz
Publikováno v:
Nanomaterials, Vol 11, Iss 7, p 1641 (2021)
In recent years, cellulose nanocrystals (CNCs) have emerged as a leading biomass-based nanomaterial owing to their unique functional properties and sustainable resourcing. Sulfated cellulose nanocrystals (sCNCs), produced by sulfuric acid-assisted hy
Externí odkaz:
https://doaj.org/article/3e9bcdd2b429403ba8d6c98668043145
Autor:
Yimei Jia, Bassel Akache, Gerard Agbayani, Vandana Chandan, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Usha D. Hemraz, Edmond Lam, Sophie Régnier, Felicity C. Stark, Lakshmi Krishnan, Michael J. McCluskie
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 205 (2021)
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer. SLA archaeosomes are a promising adjuvant candidate due to th
Externí odkaz:
https://doaj.org/article/65ffc8ded7204b35b0730b4fdff4a621
Autor:
Bassel Akache, Gerard Agbayani, Felicity C. Stark, Yimei Jia, Renu Dudani, Blair A. Harrison, Lise Deschatelets, Vandana Chandan, Edmond Lam, Usha D. Hemraz, Sophie Régnier, Lakshmi Krishnan, Michael J. McCluskie
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 257 (2021)
Cancer remains a leading cause of morbidity and mortality worldwide. While novel treatments have improved survival outcomes for some patients, new treatment modalities/platforms are needed to combat a wider variety of tumor types. Cancer vaccines har
Externí odkaz:
https://doaj.org/article/3f660cf4148c43c3ae261ca7eac92d92
Autor:
Rajesh Sunasee, Usha D. Hemraz
Publikováno v:
Fibers, Vol 6, Iss 1, p 15 (2018)
Cellulose nanocrystals (CNCs) are renewable nanosized materials with exceptional physicochemical properties that continue to garner a high level of attention in both industry and academia for their potential high-end material applications. These rod-
Externí odkaz:
https://doaj.org/article/ea6a343de30340ca9baed243426bbcc2