Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Uschi Leeser"'
Autor:
Alessandro Torgovnick, Jan Michel Heger, Vasiliki Liaki, Jörg Isensee, Anna Schmitt, Gero Knittel, Arina Riabinska, Filippo Beleggia, Lucie Laurien, Uschi Leeser, Christian Jüngst, Florian Siedek, Wenzel Vogel, Niklas Klümper, Hendrik Nolte, Maike Wittersheim, Lars Tharun, Roberta Castiglione, Marcus Krüger, Astrid Schauss, Sven Perner, Manolis Pasparakis, Reinhard Büttner, Thorsten Persigehl, Tim Hucho, Grit Sophie Herter-Sprie, Björn Schumacher, Hans Christian Reinhardt
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1027-1039.e6 (2018)
Summary: Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to gen
Externí odkaz:
https://doaj.org/article/662c648938254acfa54677dfa23bd2fb
Autor:
Jorge Boucas, Christian Fritz, Anna Schmitt, Arina Riabinska, Lisa Thelen, Martin Peifer, Uschi Leeser, Peter Nuernberg, Janine Altmueller, Matthias Gaestel, Christoph Dieterich, H Christian Reinhardt
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125745 (2015)
Growing evidence suggests a key role for RNA binding proteins (RBPs) in genome stability programs. Additionally, recent developments in RNA sequencing technologies, as well as mass-spectrometry techniques, have greatly expanded our knowledge on prote
Externí odkaz:
https://doaj.org/article/74cdcbf741ad491c99915e8c7231fc0e
Autor:
H. Christian Reinhardt, Lukas C. Heukamp, Winfried Edelmann, Johanna van Oers, Uschi Leeser, Gero Knittel, Laura Ivan, Ron D. Jachimowicz, Mladen Jokic, Lisa Thelen, Felix Dietlein
PDF file 3500K, Potency of KU60648 across 94 cancer cell lines (Figure S1), comparison of KU60648-sensitivity in mutant vs. wildtype lines for 9 exemplary DNA repair-associated genes (Figure S2), MSH3 variants and Sanger sequencing of BRCA1 (Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db39079aecdda6f5c42924ff6abace2
https://doi.org/10.1158/2159-8290.22529814.v1
https://doi.org/10.1158/2159-8290.22529814.v1
Autor:
H. Christian Reinhardt, Lukas C. Heukamp, Winfried Edelmann, Johanna van Oers, Uschi Leeser, Gero Knittel, Laura Ivan, Ron D. Jachimowicz, Mladen Jokic, Lisa Thelen, Felix Dietlein
PDF file 129K, Supplementary Methods provide additional information on experimental techniques and data analysis. Supplementary Legends describe supplementary figures S1-S10 and supplementary table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75160b20592e9f67b8aba646ceb3a10a
https://doi.org/10.1158/2159-8290.22529808
https://doi.org/10.1158/2159-8290.22529808
Autor:
H. Christian Reinhardt, Lukas C. Heukamp, Winfried Edelmann, Johanna van Oers, Uschi Leeser, Gero Knittel, Laura Ivan, Ron D. Jachimowicz, Mladen Jokic, Lisa Thelen, Felix Dietlein
PDF file 37K, List of all cell lines included in this study. Cell line name, GI50 of KU60648 from initial cell line screen, sensitivity classification as well as mutation annotation source are recorded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a8406a03aac1a7c1207c55c27a0013
https://doi.org/10.1158/2159-8290.22529811.v1
https://doi.org/10.1158/2159-8290.22529811.v1
Autor:
Hans Christian Reinhardt, Martin Peifer, Sven Perner, Reinhard Büttner, Uschi Leeser, Michael Nowak, Julie George, Tsun-Po Yang, Daniela Welcker, Gero Knittel, Anna Schmitt
In this file we show additional data which support the main findings in our manuscript, e.g. an overview of all immunofluorescent and histological images, population doubling of the cell lines used, additional in vivo data on etoposide and cisplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844cf0a2ae24aff91729d8e34537cdaf
https://doi.org/10.1158/0008-5472.22413809
https://doi.org/10.1158/0008-5472.22413809
Autor:
Hans Christian Reinhardt, Martin Peifer, Sven Perner, Reinhard Büttner, Uschi Leeser, Michael Nowak, Julie George, Tsun-Po Yang, Daniela Welcker, Gero Knittel, Anna Schmitt
Defects in maintaining genome integrity are a hallmark of cancer. The DNA damage response kinase ATM is frequently mutated in human cancer, but the significance of these events to chemotherapeutic efficacy has not been examined deeply in whole organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e508a861e54342bc7ffdfa9b2ae0562
https://doi.org/10.1158/0008-5472.c.6508823.v1
https://doi.org/10.1158/0008-5472.c.6508823.v1
Autor:
Hans Christian Reinhardt, Martin Peifer, Sven Perner, Reinhard Büttner, Uschi Leeser, Michael Nowak, Julie George, Tsun-Po Yang, Daniela Welcker, Gero Knittel, Anna Schmitt
This file contains a list of additional methods used in this study, e.g. in situ hybridisation, PCR, immunoblotting, apoptotic assay, population doubling, and statistical analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a2f8ad1236b141f88ba897405726d2
https://doi.org/10.1158/0008-5472.22413806.v1
https://doi.org/10.1158/0008-5472.22413806.v1
Autor:
Filippo Beleggia, Hendrik Nolte, Niklas Klümper, Vasiliki Liaki, Hans Christian Reinhardt, Lars Tharun, Alessandro Torgovnick, Florian Siedek, Sven Perner, Jörg Isensee, Jan Michel Heger, Lucie Laurien, Gero Knittel, Maike Wittersheim, Reinhard Büttner, Anna Schmitt, Manolis Pasparakis, Arina Riabinska, Uschi Leeser, Wenzel Vogel, Christian Jüngst, Roberta Castiglione, Thorsten Persigehl, Grit Herter-Sprie, Tim Hucho, Astrid Schauss, Björn Schumacher, Marcus Krüger
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1027-1039.e6 (2018)
Summary: Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to gen
Autor:
Alessandro, Torgovnick, Jan Michel, Heger, Vasiliki, Liaki, Jörg, Isensee, Anna, Schmitt, Gero, Knittel, Arina, Riabinska, Filippo, Beleggia, Lucie, Laurien, Uschi, Leeser, Christian, Jüngst, Florian, Siedek, Wenzel, Vogel, Niklas, Klümper, Hendrik, Nolte, Maike, Wittersheim, Lars, Tharun, Roberta, Castiglione, Marcus, Krüger, Astrid, Schauss, Sven, Perner, Manolis, Pasparakis, Reinhard, Büttner, Thorsten, Persigehl, Tim, Hucho, Grit Sophie, Herter-Sprie, Björn, Schumacher, Hans Christian, Reinhardt
Publikováno v:
Cell reports. 25(4)
Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to generate a C