Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Usama M. Ammar"'
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Akademický článek
Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties
Autor: Kamelia M. Amin, Ossama M. El-Badry, Doaa E. Abdel Rahman, Magda H. Abdellattif, Mohammed A. S. Abourehab, Mahmoud H. El-Maghrabey, Fahmy G. Elsaid, Mohamed A. El Hamd, Ahmed Elkamhawy, Usama M. Ammar
Publikováno v: Pharmaceutics, Vol 14, Iss 9, p 1954 (2022)
Inhibition of PDE5 results in elevation of cGMP leading to vascular relaxation and reduction in the systemic blood pressure. Therefore, PDE5 inhibitors are used as antihypertensive and antianginal agents in addition to their major use as male erectil
Externí odkaz: https://doaj.org/article/5f25561b2fb14338b850b5a5cdc235a1
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3
Akademický článek
2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation
Autor: Mohamed H. Elsherbeny, Usama M. Ammar, Magda H. Abdellattif, Mohammed A. S. Abourehab, Ahmed Abdeen, Samah F. Ibrahim, Doaa Abdelrahaman, Wessam Mady, Eun Joo Roh, Ahmed Elkamhawy
Publikováno v: Life, Vol 12, Iss 6, p 876 (2022)
New quinazoline derivatives were designed based on the structural modification of the reported inhibitors to enhance their selectivity toward Aurora A. The synthesized compounds were tested over Aurora A, and a cytotoxicity assay was performed over N
Externí odkaz: https://doaj.org/article/c798ad6b6816443badf3a6640507bd94
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4
Akademický článek
Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening
Autor: Ahmed Elkamhawy, Usama M. Ammar, Sora Paik, Magda H. Abdellattif, Mohamed H. Elsherbeny, Kyeong Lee, Eun Joo Roh
Publikováno v: Molecules, Vol 26, Iss 17, p 5324 (2021)
Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2. Compound
Externí odkaz: https://doaj.org/article/2939100a6d6243e28c35867f51165a6f
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8
Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAF
Autor: Eslam M H, Ali, Karim I, Mersal, Usama M, Ammar, Seyed-Omar, Zaraei, Mohammed S, Abdel-Maksoud, Mohammed I, El-Gamal, Md Mamunul, Haque, Tanuza, Das, Eunice EunKyeong, Kim, Jun-Seok, Lee, Kwan Hyi, Lee, Hee-Kwon, Kim, Chang-Hyun, Oh
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 171
In the current article, we introduce design of a new series of 4-(imidazol-5-yl)pyridines with improved anticancer activity and selective B-RAF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::865dc4c3f7d2e1baefd2ed7b2656cb37
https://pubmed.ncbi.nlm.nih.gov/34995782
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9
Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening
Autor: Sora Paik, Magda H. Abdellattif, Eun Joo Roh, Kyeong Lee, Mohamed H. Elsherbeny, Usama M. Ammar, Ahmed Elkamhawy
Publikováno v: Molecules, Vol 26, Iss 5324, p 5324 (2021)
Molecules
Volume 26
Issue 17
Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2. Compound
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aead78541e4fc4d4dd3d39e05d9ebe1
https://www.mdpi.com/1420-3049/26/17/5324
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