Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Usa, Reilly"'
Autor:
Emma King-Smith, Felix A. Faber, Usa Reilly, Anton V. Sinitskiy, Qingyi Yang, Bo Liu, Dennis Hyek, Alpha A. Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Structural diversification of lead molecules is a key component of drug discovery to explore chemical space. Late-stage functionalizations (LSFs) are versatile methodologies capable of installing functional handles on richly decorated interm
Externí odkaz:
https://doaj.org/article/f479aef07e3646c6b4b15365b07e1162
Autor:
Emma King-Smith, Felix Faber, Usa Reilly, Anton Sinitskiy, Qingyi Yang, Bo Liu, Dennis Hyek, Alpha Lee
Structural diversification of lead molecules is a key component of drug discovery to explore chemical space. Late stage functionalizations (LSFs) are versatile methodologies capable of installing functional handles on richly decorated intermediates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3dec14f4b80ad9edd74d1765f524d38
https://doi.org/10.21203/rs.3.rs-2741247/v1
https://doi.org/10.21203/rs.3.rs-2741247/v1
Transformation of C-H to C-F bonds in organic compounds can be used in drug design to easily diversify molecular series under exploration. A particularly attractive fluorination reaction is the recently discovered aliphatic C-H bonds fluorination cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57fd8989b202f0031b1306d2e2765a7
https://doi.org/10.26434/chemrxiv-2022-2vtzg
https://doi.org/10.26434/chemrxiv-2022-2vtzg
Autor:
Dennis Hyek, Jinshan Chen, R. Scott Obach, Melissa Wagenaar, Mark W. Bundesmann, Asser Bassyouni, Jeremy T. Starr, Maria S. Brown, Stephen Jenkinson, Manjinder S. Lall, Gregory Ciszewski, James Bradow, Gregory S. Walker, Senliang Pan, Douglas K. Spracklin, Bo Liu, Neal W. Sach, Daniel J Smaltz, Anne E. Hagen, Usa Reilly
Publikováno v:
Journal of Medicinal Chemistry. 63:7268-7292
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Autor:
Andrew P. Tomaras, Craig J. McPherson, Michael Kuhn, Arlene Carifa, Lisa Mullins, David George, Charlene Desbonnet, Tess M. Eidem, Justin I. Montgomery, Matthew F. Brown, Usa Reilly, Alita A. Miller, John P. O’Donnell
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT The problem of multidrug resistance in serious Gram-negative bacterial pathogens has escalated so severely that new cellular targets and pathways need to be exploited to avoid many of the preexisting antibiotic resistance mechanisms that are
Externí odkaz:
https://doaj.org/article/e21fa61d149c45b28c2a269c230984e1
Autor:
Lin Lin, Brandon Tan, Paul Pantapalangkoor, Tiffany Ho, Beverlie Baquir, Andrew Tomaras, Justin I. Montgomery, Usa Reilly, Elsa G. Barbacci, Kristine Hujer, Robert A. Bonomo, Lucia Fernandez, Robert E. W. Hancock, Mark D. Adams, Samuel W. French, Virgil S. Buslon, Brad Spellberg
Publikováno v:
mBio, Vol 3, Iss 5 (2012)
ABSTRACT New treatments are needed for extensively drug-resistant (XDR) Gram-negative bacilli (GNB), such as Acinetobacter baumannii. Toll-like receptor 4 (TLR4) was previously reported to enhance bacterial clearance of GNB, including A. baumannii. H
Externí odkaz:
https://doaj.org/article/98a27678de9b43609cdeb2a615fb073e
Autor:
Manjinder S, Lall, Asser, Bassyouni, James, Bradow, Maria, Brown, Mark, Bundesmann, Jinshan, Chen, Gregory, Ciszewski, Anne E, Hagen, Dennis, Hyek, Stephen, Jenkinson, Bo, Liu, R Scott, Obach, Senliang, Pan, Usa, Reilly, Neal, Sach, Daniel J, Smaltz, Douglas K, Spracklin, Jeremy, Starr, Melissa, Wagenaar, Gregory S, Walker
Publikováno v:
Journal of medicinal chemistry. 63(13)
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Autor:
Martins S. Oderinde, M. Christina White, Jeffrey T. Kohrt, Raundi E. Quevedo, Usa Reilly, Kaibo Feng
Publikováno v:
Nature
Frequently referred to as the 'magic methyl effect', the installation of methyl groups-especially adjacent (α) to heteroatoms-has been shown to dramatically increase the potency of biologically active molecules1-3. However, existing methylation meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0578f0b225ab399f972986c5e583b455
https://europepmc.org/articles/PMC8006464/
https://europepmc.org/articles/PMC8006464/
Autor:
Brian P. Boscoe, David A. Foley, Chao Li, Usa Reilly, Kathleen A. Farley, Manjinder S. Lall, Dennis P. Anderson, Matthew R. Reese, Jiangli Yan, Mark W. Bundesmann
Publikováno v:
Magnetic Resonance in Chemistry. 55:348-354
In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and ot
Autor:
Xuan, Feng, Nawaf, Al Maharik, Axel, Bartholomé, Jeffrey E, Janso, Usa, Reilly, David, O'Hagan
Publikováno v:
Organicbiomolecular chemistry. 15(38)
Deuterium incorporations from [