3-Aza-6—F-18-fluor-isatosäureanhydride (F-18-AFIAs) - neue leicht zugängliche prosthetische Gruppen für die indirekte Radiomarkierung

Autor: Willmann, M, Zlatopolskiy, BD, Donnerstag, L, Urusova, EA, Endepols, H, Neumaier, B

Publikováno v: Nuklearmedizin. Nuclear medicine; April 2021, Vol. 60 Issue: 2

Radiosynthesis and Preclinical Evaluation of m -[ ¹⁸ F]FET and [ ¹⁸ F]FET-OMe as Novel [ ¹⁸ F]FET Analogs for Brain Tumor Imaging.

Autor: Gröner B; Forschungszentrum Jülich GmbH, Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Wilhelm-Johnen-Straße, Jülich 52428, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany., Hoffmann C; Forschungszentrum Jülich GmbH, Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Wilhelm-Johnen-Straße, Jülich 52428, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany., Endepols H; Forschungszentrum Jülich GmbH, Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Wilhelm-Johnen-Straße, Jülich 52428, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany.; Faculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany., Urusova EA; Forschungszentrum Jülich GmbH, Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Wilhelm-Johnen-Straße, Jülich 52428, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany., Brugger M; Forschungszentrum Jülich GmbH, Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Wilhelm-Johnen-Straße, Jülich 52428, Germany., Neumaier F; Forschungszentrum Jülich GmbH, Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Wilhelm-Johnen-Straße, Jülich 52428, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany., Timmer M; Faculty of Medicine and University Hospital Cologne, Center for Neurosurgery, Department of General Neurosurgery, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany., Neumaier B; Forschungszentrum Jülich GmbH, Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Wilhelm-Johnen-Straße, Jülich 52428, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany., Zlatopolskiy BD; Forschungszentrum Jülich GmbH, Nuclear Chemistry (INM-5), Institute of Neuroscience and Medicine, Wilhelm-Johnen-Straße, Jülich 52428, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, Cologne 50937, Germany.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Jun 03; Vol. 21 (6), pp. 2795-2812. Date of Electronic Publication: 2024 May 15.

Next Generation Copper Mediators for the Efficient Production of ¹⁸ F-Labeled Aromatics.

Autor: Hoffmann C; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany., Kolks N; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany., Smets D; Faculty of Mathematics and Natural Sciences, Department of Chemistry, Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939, Cologne, Germany., Haseloer A; Faculty of Mathematics and Natural Sciences, Department of Chemistry, Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939, Cologne, Germany., Gröner B; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany., Urusova EA; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany., Endepols H; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany.; Faculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany., Neumaier F; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany., Ruschewitz U; Faculty of Mathematics and Natural Sciences, Department of Chemistry, Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939, Cologne, Germany., Klein A; Faculty of Mathematics and Natural Sciences, Department of Chemistry, Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939, Cologne, Germany., Neumaier B; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany., Zlatopolskiy BD; Faculty of Medicine and University Hospital Cologne, Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jan 09; Vol. 29 (2), pp. e202202965. Date of Electronic Publication: 2022 Nov 17.

Preparation of labeled aromatic amino acids via late-stage ¹⁸ F-fluorination of chiral nickel and copper complexes.

Autor: Craig A; Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5 Nuclear Chemistry, 52425 Jülich, Germany. b.neumaier@fz-juelich.de and Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany and Max Planck Institute for Metabolism Research, Gleueler Str. 50, 50931 Cologne, Germany., Kolks N; Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5 Nuclear Chemistry, 52425 Jülich, Germany. b.neumaier@fz-juelich.de and Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Urusova EA; Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5 Nuclear Chemistry, 52425 Jülich, Germany. b.neumaier@fz-juelich.de and Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Zischler J; Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5 Nuclear Chemistry, 52425 Jülich, Germany. b.neumaier@fz-juelich.de and Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Brugger M; Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5 Nuclear Chemistry, 52425 Jülich, Germany. b.neumaier@fz-juelich.de., Endepols H; Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5 Nuclear Chemistry, 52425 Jülich, Germany. b.neumaier@fz-juelich.de and Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany and Department of Nuclear Medicine, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Neumaier B; Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5 Nuclear Chemistry, 52425 Jülich, Germany. b.neumaier@fz-juelich.de and Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany and Max Planck Institute for Metabolism Research, Gleueler Str. 50, 50931 Cologne, Germany., Zlatopolskiy BD; Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5 Nuclear Chemistry, 52425 Jülich, Germany. b.neumaier@fz-juelich.de and Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany and Max Planck Institute for Metabolism Research, Gleueler Str. 50, 50931 Cologne, Germany.

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Aug 19; Vol. 56 (66), pp. 9505-9508.

Discovery of ¹⁸ F-JK-PSMA-7, a PET Probe for the Detection of Small PSMA-Positive Lesions.

Autor: Zlatopolskiy BD; Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany.; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germany.; Max Planck Institute for Metabolism Research, Cologne, Germany; and., Endepols H; Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany.; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germany.; Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany., Krapf P; Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany.; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germany., Guliyev M; Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany., Urusova EA; Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany.; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germany., Richarz R; Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany.; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germany., Hohberg M; Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany., Dietlein M; Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany., Drzezga A; Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany., Neumaier B; Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany b.neumaier@fz-juelich.de.; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germany.; Max Planck Institute for Metabolism Research, Cologne, Germany; and.

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2019 Jun; Vol. 60 (6), pp. 817-823. Date of Electronic Publication: 2018 Nov 02.