Organ-specific electrophile responsivity mapping in live C. elegans.

Autor: Liu J; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK; Swiss Federal Institute of Technology Lausanne, Lausanne 1015, Switzerland., Kulkarni A; Swiss Federal Institute of Technology Lausanne, Lausanne 1015, Switzerland; Friedrich Schiller University, 07737 Jena, Germany., Gao YQ; Swiss Federal Institute of Technology Lausanne, Lausanne 1015, Switzerland., Urul DA; Swiss Federal Institute of Technology Lausanne, Lausanne 1015, Switzerland; AssayQuant Technologies, Marlboro, MA 01752, USA., Hamelin R; Swiss Federal Institute of Technology Lausanne, Lausanne 1015, Switzerland., Novotny BÁ; Swiss Federal Institute of Technology Lausanne, Lausanne 1015, Switzerland., Long MJC; University of Lausanne, Lausanne 1015, Switzerland. Electronic address: marcusjohncurtis.long@unil.ch., Aye Y; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK; Swiss Federal Institute of Technology Lausanne, Lausanne 1015, Switzerland. Electronic address: yimon.aye@chem.ox.ac.uk.

Publikováno v: Cell [Cell] 2024 Nov 02. Date of Electronic Publication: 2024 Nov 02.

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.

Autor: Wittlinger F; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany., Ogboo BC; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Shevchenko E; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies' Eberhard Karls Universität Tübingen, 72076, Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076, Tübingen, Germany., Damghani T; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Pham CD; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Schaeffner IK; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Oligny BT; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Chitnis SP; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA., Beyett TS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, 5119 Rollins Research Center, 1510 Clifton Rd, Atlanta, GA, 30322, USA., Rasch A; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany., Buckley B; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA., Urul DA; AssayQuant Technologies, Inc., Marlboro, MA, 01752, USA., Shaurova T; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA., May EW; AssayQuant Technologies, Inc., Marlboro, MA, 01752, USA., Schaefer EM; AssayQuant Technologies, Inc., Marlboro, MA, 01752, USA., Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Hershberger PA; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA., Poso A; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies' Eberhard Karls Universität Tübingen, 72076, Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076, Tübingen, Germany.; School of Pharmacy, University of Eastern Finland, 70210, Kuopio, Finland., Laufer SA; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany. stefan.laufer@uni-tuebingen.de.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies' Eberhard Karls Universität Tübingen, 72076, Tübingen, Germany. stefan.laufer@uni-tuebingen.de.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076, Tübingen, Germany. stefan.laufer@uni-tuebingen.de., Heppner DE; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. davidhep@buffalo.edu.; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA. davidhep@buffalo.edu.; Department of Structural Biology, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. davidhep@buffalo.edu.

Publikováno v: Communications chemistry [Commun Chem] 2024 Feb 20; Vol. 7 (1), pp. 38. Date of Electronic Publication: 2024 Feb 20.

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).

Autor: Heppner DE; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States.; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States., Wittlinger F; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Beyett TS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Shaurova T; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States., Urul DA; AssayQuant Technologies, Inc., 260 Cedar Hill St., Marlboro, Massachusetts 01752, United States., Buckley B; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States., Pham CD; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States., Schaeffner IK; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Yang B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Ogboo BC; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States., May EW; AssayQuant Technologies, Inc., 260 Cedar Hill St., Marlboro, Massachusetts 01752, United States., Schaefer EM; AssayQuant Technologies, Inc., 260 Cedar Hill St., Marlboro, Massachusetts 01752, United States., Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Laufer SA; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tübingen, Germany., Hershberger PA; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Nov 10; Vol. 13 (12), pp. 1856-1863. Date of Electronic Publication: 2022 Nov 10 (Print Publication: 2022).

Single-Protein-Specific Redox Targeting in Live Mammalian Cells and C. elegans.

Autor: Van Hall-Beauvais A; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York.; Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland., Zhao Y; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York.; Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland., Urul DA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York.; Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland., Long MJC; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York., Aye Y; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York.; Department of Biochemistry, Weill Cornell Medicine, New York, New York.; Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland.

Publikováno v: Current protocols in chemical biology [Curr Protoc Chem Biol] 2018 Sep; Vol. 10 (3), pp. e43. Date of Electronic Publication: 2018 Aug 07.

Precision Electrophile Tagging in Caenorhabditis elegans.

Autor: Long MJC; Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States., Urul DA; Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States., Chawla S; Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States., Lin HY; Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States., Zhao Y; Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States., Haegele JA; Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States., Wang Y; Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States., Aye Y; Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States.; Department of Biochemistry, Weill Cornell Medicine , New York, New York 10065, United States.

Publikováno v: Biochemistry [Biochemistry] 2018 Jan 16; Vol. 57 (2), pp. 216-220. Date of Electronic Publication: 2017 Sep 12.