Integrity assay for messenger RNA in mouse and human brain samples and synaptosomal preparations

Autor: Daina Bujanauskiene, Kajus Merkevicius, Ugne Kuliesiute, Jaroslav Denkovskij, Simonas Kutanovas, Gediminas Luksys, Saulius Rocka, Eiva Bernotiene, Urte Neniskyte

Publikováno v: iScience, Vol 27, Iss 8, Pp 110419- (2024)

Summary: Traditionally, RNA integrity evaluation is based on ribosomal RNAs (rRNAs). Nevertheless, gene expression studies are usually focused on protein-coding messenger RNAs (mRNAs). Here, we present an RT-qPCR-based assay, which estimates mRNA int

Externí odkaz: https://doaj.org/article/62e439f24b56404d86b622b428b33b26

SIALIC ACID ON THE NEURONAL SURFACE GUIDES CIRCUIT DEVELOPMENT AND FUNCTION: FROM MOUSE MODELS TO HUMAN BRAIN TISSUE INVESTIGATIONS

Autor: Ugne Kuliesiute, Rimas Prokopovicius, Ugne Kisieliute, Kajus Merkevicius, Gediminas Luksys, Saulius Rocka, Urte Neniskyte

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S111- (2023)

Externí odkaz: https://doaj.org/article/16d82a9200d8421594b81263001e41d2

MACHINE LEARNING-BASED DENDRITIC SPINE SEGMENTATION AND QUANTIFICATION

Autor: Lina Saveikyte, Kristina Jevdokimenko, Simona Skiotyte, Gintare Urbonaite, Ilja Karanin, Urte Neniskyte

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S339- (2023)

Externí odkaz: https://doaj.org/article/6c7ee91510b74463aed7ce1ace021511

The impact of maternal high-fat diet on offspring neurodevelopment

Autor: Gintare Urbonaite, Agne Knyzeliene, Fanny Sophia Bunn, Adomas Smalskys, Urte Neniskyte

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on their brain health and behavior. During the past three decades, obesity has rapidly increased in the whole human population worldwide, including women of repro

Externí odkaz: https://doaj.org/article/af2db923ed4046b195c35260d0e46244

Microglia states and nomenclature

Autor: Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brône, Guy C. Brown, Oleg Butovsky, Monica J. Carson, Bernardo Castellano, Marco Colonna, Sally A. Cowley, Colm Cunningham, Dimitrios Davalos, Philip L. De Jager, Bart de Strooper, Adam Denes, Bart J.L. Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K. Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta González, Siamon Gordon, Manuel B. Graeber, Andrew D. Greenhalgh, Pierre Gressens, Melanie Greter, David H. Gutmann, Christian Haass, Michael T. Heneka, Frank L. Heppner, Soyon Hong, David A. Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W. McColl, Veronique E. Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J. Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V. Hugh Perry, Phillip G. Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M. Ransohoff, Michael W. Salter, Anne Schaefer, Dorothy P. Schafer, Michal Schwartz, Mikael Simons, Cody J. Smith, Wolfgang J. Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valérie Wittamer, Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray

Publikováno v: Neuron
Neuron, vol 110, iss 21
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M-E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, de Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L-H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L-J & Wyss-Coray, T 2022, ' Microglia states and nomenclature : A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron 110(21), 3458-3483 (2022). doi:10.1016/j.neuron.2022.10.020
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, De Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L J & Wyss-Coray, T 2022, ' Microglia states and nomenclature: A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron, 2022, 110 (21), pp.3458-3483. ⟨10.1016/j.neuron.2022.10.020⟩

International audience; Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603341ba45a426c6d4f33e2cb8a2abc6
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