Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Urszula Luchowska-Stańska"'
Autor:
Jolanta Wiejak, Urszula Luchowska-Stańska, Pingyuan Wang, Jia Zhou, Pasquale Maffia, David Morgan, Graeme Barker, Stephen J. Yarwood
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The N-acylsulfonamide derivative, I942, represents the first non-cyclic nucleotide partial agonist of EPAC1. This was soon followed by the identification of the I942 analogues, PW0381, PW0521 and PWO577 and a series of benzofuran oxoacetic a
Externí odkaz:
https://doaj.org/article/0ea9c45cb0cf4ab2a8adfd58f7169556
Autor:
Hanna K. Buist, Urszula Luchowska-Stańska, Boy van Basten, Jessica Valli, Brian O. Smith, George S. Baillie, Colin Rickman, Bryon Ricketts, Alex Davidson, Ryan Hannam, Joanne Sunderland, Stephen J. Yarwood
Publikováno v:
Cells, Vol 10, Iss 9, p 2307 (2021)
An exchange protein directly activated by cAMP 1 (EPAC1) is an intracellular sensor for cAMP that is involved in a wide variety of cellular and physiological processes in health and disease. However, reagents are lacking to study its association with
Externí odkaz:
https://doaj.org/article/a89d1e2a0a6848fdafc5f56006531a1d
Autor:
Holger Rehmann, Graeme Barker, Haiying Chen, Stephen J. Yarwood, Jia Zhou, Boy van Basten, Jolanta Wiejak, Emma Lochhead, David Morgan, Padraic Whelan, Zhiqing Liu, Urszula Luchowska-Stańska, Pingyuan Wang
Publikováno v:
Journal of Medicinal Chemistry. 63:5159-5184
Exchange proteins directly activated by cAMP (EPAC) play a central role in various biological functions, and activation of the EPAC1 protein has shown potential benefits for the treatment of various human diseases. Herein, we report the synthesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fbc6e7ea23a19108b7bae605c2b64b
https://doi.org/10.1021/acs.jmedchem.9b02094
https://doi.org/10.1021/acs.jmedchem.9b02094
Autor:
Hebatallah Mohamed, Jia Zhou, Haiying Chen, Nicholas G. Jentsch, Stephen Boulton, Stephen J. Yarwood, Urszula Luchowska-Stańska, Jinfeng Huang, Pingyuan Wang, Alison L. Armstrong, Giuseppe Melacini, Hongzhao Shao, Jakob Magolan
Publikováno v:
Journal of Medicinal Chemistry. 63:4762-4775
The exchange protein activated by cAMP (EPAC) is a promising drug target for a wide disease range, from neurodegeneration and infections to cancer and cardiovascular conditions. A novel partial agonist of the EPAC isoform 1 (EPAC1), I942, was recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364d4956b873f9344abc9701e190161a
https://doi.org/10.1021/acs.jmedchem.9b02151
https://doi.org/10.1021/acs.jmedchem.9b02151
Publikováno v:
Biochemical Society Transactions
The cellular signalling enzymes, EPAC1 and EPAC2, have emerged as key intracellular sensors of the secondary messenger cyclic 3′,5′-adenosine monophosphate (cyclic adenosine monophosphate) alongside protein kinase A. Interest has been galvanised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f1d34920d181016a5a2ff0dbb23a4e
https://doi.org/10.1042/bst20190254
https://doi.org/10.1042/bst20190254
Autor:
John Robinson, Stuart P. McElroy, Philip S. Jones, Graeme Barker, Euan Parnell, Helma Rutjes, Lindsay Robinson, Angus Morrison, Elizabeth M. Beck, Andrew D. Pannifer, Martin Timmerman, Angela Cowley, Jolanta Wiejak, Veronique Hamon, Holger Rehmann, Urszula Luchowska-Stańska, Jonathan Gillespie, David Morgan, Stephen J. Yarwood, Alison Porter, Pravin Mahajan
Publikováno v:
Cells
Volume 8
Issue 11
Volume 8
Issue 11
Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677a116fcb1675edbcc36ca4fb30482f
https://pubmed.ncbi.nlm.nih.gov/31726720
https://pubmed.ncbi.nlm.nih.gov/31726720
Autor:
Boy van Basten, Jolanta Wiejak, Stephen J. Yarwood, Graham Hamilton, Urszula Luchowska-Stańska
Publikováno v:
Biochimica et Biophysica Acta. Molecular Cell Research
Exchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene, the protein produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf432d5ecfcc76e1a4b6d3d0edb87b6a
https://pubmed.ncbi.nlm.nih.gov/30414891
https://pubmed.ncbi.nlm.nih.gov/30414891