Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response

Autor: Julia Merkenschlager, Mickaël J. Ploquin, Urszula Eksmond, Rakieb Andargachew, Georgina Thorborn, Andrew Filby, Marion Pepper, Brian Evavold, George Kassiotis

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

During an immune response, CD4+ T cell repertoire is thought to increase in avidity at the expense of diversity. Here the authors show that B cells act as antigen-presenting cells to boost the development of low-avidity T cell clones, diversifying th

Externí odkaz: https://doaj.org/article/25bffa91449947648b99e2c787621c0f

Antigenicity of peptides comprising the immunosuppressive domain of the retroviral envelope glycoprotein [version 1; referees: 2 approved]

Autor: Bryony Jenkins, Urszula Eksmond, George Young, George Kassiotis

Publikováno v: Wellcome Open Research, Vol 1 (2016)

To achieve persistent infection of the host, viruses often subvert or suppress host immunity through mechanisms that are not entirely understood. The envelope glycoprotein of several retroviruses is thought to possess potent immunosuppressive activit

Externí odkaz: https://doaj.org/article/5f0e99e7cb2a4915b40392b92b42f1d2

Gv1, a Zinc Finger Gene Controlling Endogenous MLV Expression

Autor: Peter L. Oliver, Aaron K W Ferron, Veera Panova, George Kassiotis, George R. Young, Urszula Eksmond, Jonathan P. Stoye

Publikováno v: Molecular Biology and Evolution

The genomes of inbred mice harbor around 50 endogenous murine leukemia virus (MLV) loci, although the specific complement varies greatly between strains. The Gv1 locus is known to control the transcription of endogenous MLVs and to be the dominant de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274af2f68d71d5b10eec343ad7c20f0a
https://doi.org/10.1093/molbev/msab039

Restoration of Endogenous Retrovirus Infectivity Impacts Mouse Cancer Models

Autor: Eleonora Ottina, Thomas Tüting, Urszula Eksmond, George R. Young, Juliette Roels, Prisca Levy, Dinis Pedro Calado, George Kassiotis, Jonathan P. Stoye, Julia Merkenschlager

Publikováno v: Cancer immunology research. 6(11)

Mouse models have been instrumental in establishing fundamental principles of cancer initiation and progression and continue to be invaluable in the discovery and further development of cancer therapies. Nevertheless, important aspects of human disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3dea7b9ac70a985b8202eb74a35e96
https://pubmed.ncbi.nlm.nih.gov/30143537

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus

Autor: George R. Young, Tiziano Donnarumma, Wibke Bayer, Nadine Bongard, Claude Boyer, Urszula Eksmond, Stephen L. Nutt, George Kassiotis, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Julia Merkenschlager, Ulf Dittmer

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2016, 17 (6), pp.1571-1583. ⟨10.1016/j.celrep.2016.10.013⟩
Cell Reports, 2016, 17 (6), pp.1571-1583. ⟨10.1016/j.celrep.2016.10.013⟩
Cell Reports, Vol 17, Iss 6, Pp 1571-1583 (2016)

Summary CD4+ T cells develop distinct and often contrasting helper, regulatory, or cytotoxic activities. Typically a property of CD8+ T cells, granzyme-mediated cytotoxic T cell (CTL) potential is also exerted by CD4+ T cells. However, the conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364caec89459d15f87a363c58f822aac
https://hal.archives-ouvertes.fr/hal-01438159