Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Urszula Derewenda"'
Autor:
Darkhan Utepbergenov, Paulina M Hennig, Urszula Derewenda, Mykhaylo V Artamonov, Avril V Somlyo, Zygmunt S Derewenda
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164343 (2016)
Ribosomal S6 kinases (RSK) play important roles in cell signaling through the mitogen-activated protein kinase (MAPK) pathway. Each of the four RSK isoforms (RSK1-4) is a single polypeptide chain containing two kinase domains connected by a linker se
Externí odkaz:
https://doaj.org/article/d40be82a84454e1082d3881bafeba8be
Publikováno v:
IUBMB Life
C—H· · ·O hydrogen bonds constitute a unique class of cohesive interactions. Their properties are similar to those of canonical H-bonds, although their energy is significantly lower, typically in the 0.5–2.5 kcal/mol range. Polarised C—H gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c48f08dde88de4bb5995459d720627
https://europepmc.org/articles/PMC7641297/
https://europepmc.org/articles/PMC7641297/
Autor:
Malwina Radwanska, Zygmunt S. Derewenda, Daniel A. Engel, Urszula Derewenda, Tsuyoshi Miyake, Mateusz Jaskolowski, Elena K. Davydova, Anthony A. Kossiakoff
Publikováno v:
Acta Crystallographica Section D Structural Biology. 74:681-689
The vast majority of platforms for the detection of viral or bacterial antigens rely on immunoassays, typically ELISA or sandwich ELISA, that are contingent on the availability of suitable monoclonal antibodies (mAbs). This is a major bottleneck, sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23560d82b1c94475e4cf9adf014c5c8c
https://doi.org/10.1107/s2059798318007878
https://doi.org/10.1107/s2059798318007878
Autor:
Zygmunt S. Derewenda, Malgorzata Bukrejewska, Malwina Radwanska, Urszula Derewenda, Daniel A. Engel
Publikováno v:
Acta Crystallographica Section D Structural Biology. 73:767-774
Two nonstructural proteins encoded byZika virusstrain MR766 RNA, a methyltransferase and a helicase, were crystallized and their structures were solved and refined at 2.10 and 2.01 Å resolution, respectively. The NS5 methyltransferase contains a bou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19296b13bad5555b6e9db3948f171276
https://doi.org/10.1107/s2059798317010737
https://doi.org/10.1107/s2059798317010737
Autor:
Katja T. Koessmeier, Radovan Dvorsky, Mamta Jaiswal, Pontus Aspenström, Urszula Derewenda, Kazem Nouri, Ehsan Amin, Katarina Reis, Mohammad Reza Ahmadian, Avril V. Somlyo
Publikováno v:
Journal of Biological Chemistry. 291:20353-20371
RHO GTPase-activating proteins (RHOGAPs) are one of the major classes of regulators of the RHO-related protein family that are crucial in many cellular processes, motility, contractility, growth, differentiation, and development. Using database searc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::337db1aeac9af0d17f38c5d294da83db
https://doi.org/10.1074/jbc.m116.736967
https://doi.org/10.1074/jbc.m116.736967
Autor:
Urszula Derewenda, Jeffrey F. Ellena, Laura E. Baker, Daniel A. Engel, Katarzyna B. Handing, Darkhan Utepbergenov, Zygmunt S. Derewenda
Publikováno v:
Acta Crystallographica Section D Structural Biology. 72:49-58
TheFiloviridaefamily of negative-sense, single-stranded RNA (ssRNA) viruses is comprised of two species ofMarburgvirus(MARV and RAVV) and five species ofEbolavirus,i.e.Zaire (EBOV), Reston (RESTV), Sudan (SUDV), Taï Forest (TAFV) and Bundibugyo (BDB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f90e10523929d6b081f7a17afd90d2
https://doi.org/10.1107/s2059798315021439
https://doi.org/10.1107/s2059798315021439
Autor:
Swapnil K. Sonkusare, Masumi Eto, Mykhaylo V. Artamonov, Thu H. Le, Urszula Derewenda, Avril V. Somlyo, Zygmunt S. Derewenda, Eric L. Cope, Brant E. Isakson, Ko Momotani, Miranda E. Good
Publikováno v:
Science Signaling. 11
Smooth muscle contraction is triggered when Ca(2+)/calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates the regulatory light chain of myosin (RLC(20)). However, blood vessels from Mlck-deficient mouse embryos retain the ability to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f484af9aba77e94068e69f576ca9c3
https://doi.org/10.1126/scisignal.aar3924
https://doi.org/10.1126/scisignal.aar3924
Autor:
Jeffrey F. Ellena, Paulina J. Dziubańska, Daniel A. Engel, Zygmunt S. Derewenda, Urszula Derewenda
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:2420-2429
Ebolavirus(EBOV) causes severe hemorrhagic fever with a mortality rate of up to 90%. EBOV is a member of the orderMononegaviralesand, like other viruses in this taxonomic group, contains a negative-sense single-stranded (ss) RNA. The EBOV ssRNA encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fa3a3ed48f07fcfd65431f65be1f15
https://doi.org/10.1107/s1399004714014710
https://doi.org/10.1107/s1399004714014710
Autor:
Mykhaylo V. Artamonov, Urszula Derewenda, Ko Momotani, Zygmunt S. Derewenda, Andra S. Stevenson, David R. Trentham, J. Silvio Gutkind, Paul W. Read, Avril V. Somlyo
Publikováno v:
Journal of Biological Chemistry. 288:34030-34040
Many agonists, acting through G-protein-coupled receptors and Gα subunits of the heterotrimeric G-proteins, induce contraction of smooth muscle through an increase of [Ca2+]i as well as activation of the RhoA/RhoA-activated kinase pathway that ampli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f42f34b8afa61e7f246df464c32dd1
https://doi.org/10.1074/jbc.m113.514596
https://doi.org/10.1074/jbc.m113.514596
Autor:
Urszula Derewenda, Deborah A. Lannigan, P. Todd Stukenberg, Michael K. Hilinski, Gabriela Szukalska, Natalya Olekhnovich, Budhaditya Banerjee, Darkhan Utepbergenov, Zygmunt S. Derewenda
Publikováno v:
Biochemistry. 51:6499-6510
The p90 ribosomal S6 family of kinases (RSK) are potential drug targets, due to their involvement in cancer and other pathologies. There are currently only two known selective inhibitors of RSK, but the basis for selectivity is not known. One of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c8cee52c2f5848af9fbf3fcc6362ee
https://doi.org/10.1021/bi300620c
https://doi.org/10.1021/bi300620c