Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Urszula Cytlak"'
Autor:
Urszula Cytlak, Anastasia Resteu, Delfien Bogaert, Hye Sun Kuehn, Thomas Altmann, Andrew Gennery, Graham Jackson, Attila Kumanovics, Karl V. Voelkerding, Seraina Prader, Melissa Dullaers, Janine Reichenbach, Harry Hill, Filomeen Haerynck, Sergio D. Rosenzweig, Matthew Collin, Venetia Bigley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
IKZF1 is a transcription factor known to regulate mammalian B-cell development. Here the authors show that IKZF1 is required for human pDC development and regulation of DC cytokine production in patients with IKZF1 haploinsufficiency, findings which
Externí odkaz:
https://doaj.org/article/052768b869044a2d884f1ad1b5b273c9
Autor:
Agnieszka Dyrda, Urszula Cytlak, Anna Ciuraszkiewicz, Agnieszka Lipinska, Anne Cueff, Guillaume Bouyer, Stéphane Egée, Poul Bennekou, Virgilio L Lew, Serge L Y Thomas
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9447 (2010)
BackgroundThe mechanical, rheological and shape properties of red blood cells are determined by their cortical cytoskeleton, evolutionarily optimized to provide the dynamic deformability required for flow through capillaries much narrower than the ce
Externí odkaz:
https://doaj.org/article/2e10b1324ae1489fb91a2fa2c3112bce
Publikováno v:
Bigley, V, Cytlak, U & Collin, M 2019, ' Human dendritic cell immunodeficiencies ', Seminars in Cell and Developmental Biology, vol. 86, pp. 50-61 . https://doi.org/10.1016/j.semcdb.2018.02.020
The critical functions of dendritic cells (DCs) in immunity and tolerance have been demonstrated in many animal models but their non-redundant roles in humans are more difficult to probe. Human primary immunodeficiency (PID), resulting from single ge
Autor:
Rachel Queen, Venetia Bigley, Gina M. Doody, Sarah Pagan, Sheetal Maisuria, James Thaventhiran, Kile Green, Rosie Hague, Andrew Filby, Gillian Hulme, Benjamin C. Carpenter, David McDonald, Hana Lango Allen, Paul Milne, Urszula Cytlak, Matthew Collin, Anastasia Resteu, Sophie Hambleton
Publikováno v:
Cytlak, U, Resteu, A, Pagan, S, Green, K, Milne, P, Maisuria, S, McDonald, D, Hulme, G, Filby, A, Carpenter, B, Queen, R, Hambleton, S, Hague, R, Allen, H L, Thaventhiran, J E D, Doody, G, Collin, M & Bigley, V 2020, ' Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans ', Immunity . https://doi.org/10.1016/j.immuni.2020.07.003
Immunity
Immunity
Summary The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the classical DC li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f0c55cbbc2f25e9e5d27d255ae1acf
Autor:
A. J. Simpson, Gary Reynolds, Xiao-Nong Wang, Sarah Pagan, Laura Jardine, Graham H. Jackson, Urszula Cytlak, Smeera Nair, Merry Gunawan, Matthew Collin, Anna Long, Kile Green, Erin Hurst, Amy Publicover, Christopher A. Lamb, Muzlifah Haniffa, Venetia Bigley, Maharani Paramitha
Publikováno v:
Jardine, L, Cytlak, U, Gunawan, M, Reynolds, G, Green, K, Wang, X-N, Pagan, S, Paramitha, M, Lamb, C A, Long, A K, Hurst, E, Nair, S, Jackson, G H, Publicover, A, Bigley, V, Haniffa, M, Simpson, A J & Collin, M 2020, ' Donor monocyte–derived macrophages promote human acute graft-versus-host disease ', Journal of Clinical Investigation, pp. 4574-4586 . https://doi.org/10.1172/JCI133909
The Journal of Clinical Investigation
The Journal of Clinical Investigation
Myelopoiesis is invariably present and contributes to pathology in animal models of graft-versus-host disease (GVHD). In humans, a rich inflammatory infiltrate bearing macrophage markers has also been described in histological studies. In order to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b8ae9539dc73a2de539c4782b629e9
https://doi.org/10.1172/JCI133909
https://doi.org/10.1172/JCI133909
Autor:
Smeera Nair, Muzlifah Haniffa, Gary Reynolds, Xiao-Nong Wang, Merry Gunawan, Graham H. Jackson, Matthew Collin, A. J. Simpson, Amy Publicover, Kile Green, Venetia Bigley, Sarah Pagan, Urszula Cytlak, Laura Jardine, M. Pradnya, Christopher A. Lamb, Erin Hurst, Anna Long
Myelopoiesis is invariably present, and contributes to pathology, in animal models of graft versus host disease (GVHD). In humans, a rich inflammatory infiltrate bearing macrophage markers has also been described in histological studies. In order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c6839f382bfed9ca293dd44619a9f0
Autor:
Benjamin C. Carpenter, Sarah Pagan, Sophie Hambleton, Gina M. Doody, Paul Milne, James Thaventhiran, Rosie Hague, Matthew Collin, Venetia Bigley, Kile Green, Anastasia Resteu, Andrew Filby, Urszula Cytlak, Sheetal Maisuria, Hana Lango Allen, Rachel Queen, Gillian Hulme, David McDonald
Publikováno v:
SSRN Electronic Journal.
The formation of human dendritic cells (DC) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 differentially affects plasmacytoid DC (pDC) and the classical DC lineages, cDC1 and cDC2. Additionally, cDC2 are
Autor:
Margaret E, Kirkling, Urszula, Cytlak, Colleen M, Lau, Kanako L, Lewis, Anastasia, Resteu, Alireza, Khodadadi-Jamayran, Christian W, Siebel, Hélène, Salmon, Miriam, Merad, Aristotelis, Tsirigos, Matthew, Collin, Venetia, Bigley, Boris, Reizis
Publikováno v:
Kirkling, M E, Cytlak, U, Lau, C M, Lewis, K L, Resteu, A, Khodadadi-Jamayran, A, Siebel, C W, Salmon, H, Merad, M, Tsirigos, A, Collin, M, Bigley, V & Reizis, B 2018, ' Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells ', Cell Reports, vol. 23, no. 12, pp. 3658-3672 . https://doi.org/10.1016/j.celrep.2018.05.068
The IRF8-dependent subset of classical dendritic cells (cDCs), termed cDC1, is important for cross-priming cytotoxic T cell responses against pathogens and tumors. Culture of hematopoietic progenitors with DC growth factor FLT3 ligand (FLT3L) yields
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::589e960a20a306c987936eb32458be3f
https://research.manchester.ac.uk/en/publications/7a72bce5-7436-42fb-8495-9a1e44fcc644
https://research.manchester.ac.uk/en/publications/7a72bce5-7436-42fb-8495-9a1e44fcc644
Autor:
Urszula Cytlak, Oluwabukola T. Gbotosho, David C. Rees, Anke Hannemann, Sanjay Tewari, John S. Gibson
Publikováno v:
Blood Cells, Molecules & Diseases
Hannemann, A, Cytlak, U M C, Gbotosho, O T, Rees, D C, Tewari, S & Gibson, J S 2014, ' Effects of o-vanillin on K + transport of red blood cells from patients with sickle cell disease ', Blood Cells, Molecules, and Diseases, vol. 53, no. 1-2, pp. 21-26 . https://doi.org/10.1016/j.bcmd.2014.02.004
Hannemann, A, Cytlak, U M C, Gbotosho, O T, Rees, D C, Tewari, S & Gibson, J S 2014, ' Effects of o-vanillin on K + transport of red blood cells from patients with sickle cell disease ', Blood Cells, Molecules, and Diseases, vol. 53, no. 1-2, pp. 21-26 . https://doi.org/10.1016/j.bcmd.2014.02.004
Aromatic aldehydes like o-vanillin were designed to reduce the complications of sickle cell disease (SCD) by interaction with HbS, to reduce polymerisation and RBC sickling. Present results show that o-vanillin also directly affects RBC membrane perm
Publikováno v:
Cell Calcium. 51:51-56
Phosphatidylserine (PS) is usually confined to the inner leaflet of the red blood cell (RBC) membrane. It may become externalised in various conditions, however, notably in RBCs from patients with sickle cell disease (SCD) where exposed PS may contri