Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Ursula Schulze"'
Autor:
Christine E. Peters, Ursula Schulze-Gahmen, Manon Eckhardt, Gwendolyn M. Jang, Jiewei Xu, Ernst H. Pulido, Conner Bardine, Charles S. Craik, Melanie Ott, Or Gozani, Kliment A. Verba, Ruth Hüttenhain, Jan E. Carette, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Actin histidine methyltransferase SETD3 is a host factor critical for the replication of enteroviruses. Here, the authors report the 3.5 Å cryoEM structure of SETD3 interacting with enterovirus CV-B3 2A protease, defining the actin-binding SET domai
Externí odkaz:
https://doaj.org/article/22221195d9174bdcb9744f12954ad8ae
Autor:
Shiqian Qi, Zichong Li, Ursula Schulze-Gahmen, Goran Stjepanovic, Qiang Zhou, James H. Hurley
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The host super elongation complex (SEC) is hijacked by HIV-1 for viral transcription. Here the authors present the structure of RNA polymerase elongation factor ELL2 bound to the intrinsically disordered scaffold protein AFF4, identifying an ELL2 sur
Externí odkaz:
https://doaj.org/article/e30f66ef897f4bb8982ba67f0e094f26
Autor:
Ursula Schulze-Gahmen, Ignacia Echeverria, Goran Stjepanovic, Yun Bai, Huasong Lu, Dina Schneidman-Duhovny, Jennifer A Doudna, Qiang Zhou, Andrej Sali, James H Hurley
Publikováno v:
eLife, Vol 5 (2016)
HIV-1 Tat hijacks the human superelongation complex (SEC) to promote proviral transcription. Here we report the 5.9 Å structure of HIV-1 TAR in complex with HIV-1 Tat and human AFF4, CDK9, and CycT1. The TAR central loop contacts the CycT1 Tat-TAR r
Externí odkaz:
https://doaj.org/article/31e1d27483494283b8b90982f215bc2a
Publikováno v:
eLife, Vol 3 (2014)
Superelongation complexes (SECs) are essential for transcription elongation of many human genes, including the integrated HIV-1 genome. At the HIV-1 promoter, the viral Tat protein binds simultaneously to the nascent TAR RNA and the CycT1 subunit of
Externí odkaz:
https://doaj.org/article/41299cae61c448059c6429a27fbd39af
Autor:
Ursula Schulze-Gahmen, Heather Upton, Andrew Birnberg, Katherine Bao, Seemay Chou, Nevan J Krogan, Qiang Zhou, Tom Alber
Publikováno v:
eLife, Vol 2 (2013)
Human positive transcription elongation factor b (P-TEFb) phosphorylates RNA polymerase II and regulatory proteins to trigger elongation of many gene transcripts. The HIV-1 Tat protein selectively recruits P-TEFb as part of a super elongation complex
Externí odkaz:
https://doaj.org/article/a103a5737bf84775859868c0bfa4b5b2
Autor:
Hesong Han, Albert Vallejo Gracia, Joachim J. Røise, Lydia Boike, Kristoffer Leon, Ursula Schulze-Gahmen, Michael R. Stentzel, Teena Bajaj, Dake Chen, I.-Che Li, Maomao He, Kamyar Behrouzi, Zahra Khodabakhshi, Daniel K. Nomura, Mohammad R. K. Mofrad, G. Renuka Kumar, Melanie Ott, Niren Murthy
Publikováno v:
RSC advances, vol 13, iss 16
Covalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-2 have great potential as antivirals, but their non-specific reactivity with thiols has limited their development. In this report, we performed an 8000 molecule electrophile screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3654378b7f97ba0aa9cb67e570b5b4
https://doi.org/10.1039/d3ra00426k
https://doi.org/10.1039/d3ra00426k
Autor:
Benigna Schönhagen, Ursula Schulze
Publikováno v:
Schwäbische Heimat. 54:500-501
Ursula Schulze (Hrsg.): Juden in der deutschen Literatur des Mittelalters. Religiöse Konzepte - Feindbilder - Rechtfertigungen. Max Niemeyer Verlag Tübingen 2002. 290 Seiten mit 21 Abbildungen. Gebunden € 56,-. ISBN 3-484-10846-0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f732b31fd96fa499e654593d79357f91
https://doi.org/10.53458/sh.v54i4.5995
https://doi.org/10.53458/sh.v54i4.5995
Autor:
Megan L. Ken, Rohit Roy, Ainan Geng, Laura R. Ganser, Akanksha Manghrani, Bryan R. Cullen, Ursula Schulze-Gahmen, Daniel Herschlag, Hashim M. Al-Hashimi
Cellular processes are the product of interactions between biomolecules, which associate to form biologically active complexes1. These interactions are mediated by intermolecular contacts, which if disrupted, lead to alterations in cell physiology. N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67569465bada75516b698b3a9836217b
https://doi.org/10.1101/2022.12.05.519207
https://doi.org/10.1101/2022.12.05.519207
Autor:
Jessica K. Peters, Natalia Jura, Aye C. Thwin, Mehdi Bouhaddou, Fei Li, Jocelyne Lopez, Yang Li, Kuei-Ho Chen, Erron W. Titus, Huong T. Kratochvil, Victor L Lam, Christian B. Billesbølle, Tristan W. Owens, Raphael Trenker, Axel F. Brilot, Danielle L. Swaney, Ursula Schulze-Gahmen, Feng Wang, Gregory E. Merz, Jen Chen, Amy Diallo, Yang Zhang, Adam Frost, Soumya G. Remesh, Junrui Li, Edmond Linossi, Fengbo Zhou, Maliheh Safari, Yifan Cheng, Henry C. Nguyen, Andrea Fossati, Devan Diwanji, Evelyn Hernandez, Aashish Manglik, Nevan J. Krogan, Iris D. Young, Jianhua Zhao, Kyle E. Lopez, Alexandrea N. Rizo, Megan Lo, Thomas H. Pospiech, Gwendolyn M. Jang, Y. Li, Sergei Pourmal, Yuan Zhou, Miles Sasha Dickinson, Un Seng Chio, Kaihua Zhang, Caleigh M. Azumaya, Michael D Paul, Oren S. Rosenberg, Yanxin Liu, Tsz Kin Martin Tsui, Carlos Nowotny, Kate Kim, Kliment A. Verba, Loan Doan, Zanlin Yu, Adrian Pelin, Mariano C Tabios, Lorena Zuliani-Alvarez, Daniel R. Southworth, Melody G. Campbell, Ming Sun, Adamo Mancino, Kaitlin Schaefer, Frank R. Moss, Daniel Asarnow, Meghna Gupta, James S. Fraser, Komal Ishwar Pawar, Amber M. Smith, Robert M. Stroud, Tanja Kortemme, Cristina Puchades, Michelle Moritz, Nadia Herrera, Eric Tse, Mingliang Jin, David A. Agard
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv, vol 2, iss 05-19
Research Square
article-version (status) pre
article-version (number) 1
bioRxiv, vol 2, iss 05-19
Research Square
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis of those functions, remain unknown. Here, we report an atomic model for full-length Nsp2 obtained by combining cryo-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8c3bdd782cfa56f525ccd0d1740780
https://pubmed.ncbi.nlm.nih.gov/34013269
https://pubmed.ncbi.nlm.nih.gov/34013269
Autor:
Carlos Anaya, Jill K. Hacker, Ursula Schulze-Gahmen, Monica Haw, Carl L. Hanson, Chantha Kath, Debra A. Wadford, Miguel Garcia-Knight, Phillip A. Frankino, Mir M. Khalid, Jing Cheng, Claudia Sanchez San Martin, Donna Ferguson, Xianding Deng, Melanie Ott, Steve Miller, Raul Andino, Liana F. Lareau, John Bell, Mary Kate Morris, G. Renuka Kumar, Jennifer M. Hayashi, Charles Y. Chiu, Dustin R. Glasner, Peter V. Lidsky, Peera Hemarajata, Haridha Shivram, Bharath Sreekumar, Stacia K. Wyman, Sarah McMahon, Yinghong Xiao, Nicole M. Green, Scot Federman, Pei-Yi Chen, Venice Servellita, Taha Y. Taha, Nikitha P. Reddy, Jessica Streithorst, Joanna Balcerek, Candace Wang, Jordan E. Taylor, Kevin Reyes, Camille R. Simoneau, Alicia Sotomayor-Gonzalez, Amelia S. Gliwa, Alex Espinosa
Publikováno v:
Cell
Cell, vol 184, iss 13
medRxiv
article-version (status) pre
article-version (number) 1
Cell, vol 184, iss 13
medRxiv
article-version (status) pre
article-version (number) 1
We identified an emerging SARS-CoV-2 variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California, a state in the Western United States. Named B.1.427/B.1.429 to denote its 2 lineages, the variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a5005b11c981ed32272a213aa6b220
http://europepmc.org/articles/PMC8057738
http://europepmc.org/articles/PMC8057738