Výsledky vyhledávání - "Ursula Schramm"

Pharmacokinetics and Pharmacodynamics of Bimagrumab (BYM338)

Autor: Olivier Petricoul, Arman Nazarian, Uwe Schuehly, Ursula Schramm, Olivier J. David, Didier Laurent, Jens Praestgaard, Ronenn Roubenoff, Dimitris A. Papanicolaou, Daniel Rooks

Publikováno v: Clinical pharmacokinetics.

Bimagrumab is a human monoclonal antibody binding to the activin type II receptor with therapeutic potential in conditions of muscle wasting and obesity. This phase I study evaluated the pharmacokinetics (PK), pharmacodynamics (PD), and safety of var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f014f9a6e2c9589cb74e06620cf92ed
https://pubmed.ncbi.nlm.nih.gov/36527600

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Comorbidity of inflammatory bowel disease in children and adolescents with type 1 diabetes

Autor: Young Hee Lee-Barkley, Esther Bollow, Bettina Heidtmann, Ursula Schramm, Hildegard Jasser-Nitsche, Gideon de Sousa, Elisabeth Binder, Reinhard W. Holl, Susanne Bechtold-Dalla Pozza, Klemens Raile

Publikováno v: Acta Paediatrica (Oslo, Norway : 1992)

Aim To determine the prevalence of inflammatory bowel disease (IBD) in patients with type 1 diabetes (T1D) and to characterise patients with both diseases. Methods Data of 65.147 patients with T1D ≤18 years of 379 centres in Germany and Austria par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1890473523b1be23cc708e5b9ff7389f
https://doi.org/10.1111/apa.15643

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Detection ofCSF1rearrangements deleting the 3′ UTR in tenosynovial giant cell tumors

Autor: Brendan C. Dickson, Thomas Peters, Marc Sultan, David Swanson, Julie Ho, Marie-Anne Valentin, Ursula Schramm, Anita Fernandez, Elizabeth G. Demicco, Torsten O. Nielsen, Aurelie Frova‐Seguin

Publikováno v: Genes, Chromosomes and Cancer. 59:96-105

Tenosynovial giant cell tumors (TGCTs) are characterized by rearrangements of CSF1, thought to drive overexpression of macrophage colony-stimulating factor (CSF1), thereby promoting tumor growth and recruitment of non-neoplastic mononuclear and multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35815bfcde1a324567f76b80eb97892a
https://doi.org/10.1002/gcc.22807

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POS0020 EFFICACY AND SAFETY OF SECUKINUMAB IN PATIENTS WITH ROTATOR CUFF TENDINOPATHY: A 24-WEEK, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE II PROOF-OF-CONCEPT TRIAL

Autor: I.B. McInnes, A. Seroutou, Jens Praestgaard, J. Rosen, Matthias Schieker, R. Levitch, Georg Schett, Ronenn Roubenoff, Linda Mindeholm, Eckhard Weber, Didier Laurent, Ursula Schramm, Neal L. Millar

Publikováno v: Annals of the Rheumatic Diseases. 80:211.2-212

Background:Rotator cuff tendinopathy (RC TP) is a multifactorial condition and one of the most common causes of musculoskeletal burden. Current standard of care (SoC) is limited to pain relief with NSAIDs and physiotherapy. Recent evidence indicates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e204fea7bd0c132fcd8299405f7e41f
https://doi.org/10.1136/annrheumdis-2021-eular.45

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Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes

Autor: Yinuo Pang, Gaetane Woerly, Esther Sutter, Francois Pognan, Ursula Schramm, Yoav E Timsit, Marie Anne Valentin, Philippe Couttet, Armin Wolf, Beate Vogel, Ivan Demin, Birgit Jaitner, Ronenn Roubenoff

Publikováno v: The Journal of pharmacology and experimental therapeutics. 369(3)

The colony-stimulating factor-1 (CSF-1) receptor pathway has been implicated in a variety of diseases, and CSF-1-dependent mechanisms are also involved in bloodborne protein clearance. Lacnotuzumab is a novel, high-affinity, humanized, anti-CSF-1 mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef69e48a10a90d3ac1e1ed0857b5eac9
https://pubmed.ncbi.nlm.nih.gov/30894455

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Screening for Type 1 Diabetes Risk in Newborns: The Freder1k Pilot Study in Saxony

Publikováno v: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 50(1)

An increased risk for type 1 diabetes can be identified using genetic and immune markers. The Freder1k study introduces genetic testing for type 1 diabetes risk within the context of the newborn screening in order to identify newborns with a high ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43f92080aebb8b76c337a81902bb7dc
https://pubmed.ncbi.nlm.nih.gov/29121687

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18F-fluoride PET as a noninvasive imaging biomarker for determining treatment efficacy of bone active agents at the hip: A prospective, randomized, controlled clinical study

Autor: Paul Marsden, Didier Laurent, Paul Schleyer, Marie-Anne Valentin, Michelle L. Frost, Musib Siddique, Amelia E. B. Moore, Babul Borah, Ursula Schramm, Ignac Fogelman, Theodore C. Pellas, Glen M. Blake

Publikováno v: Journal of Bone and Mineral Research. 28:1337-1347

The functional imaging technique of 18F-fluoride positron emission tomography (18F-PET) allows the noninvasive quantitative assessment of regional bone formation at any skeletal site, including the spine and hip. The aim of this study was to determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9b2854821d9334af9e670d707399dda
https://doi.org/10.1002/jbmr.1862

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Active microtubule-dependent secretion of a fluorescent bile salt derivative in skate hepatocyte clusters

Autor: James L. Boyer, Surajit Nundy, Gert Fricker, John H. Henson, Nazzareno Ballatori, David N. Hager, Ursula Schramm, David S. Miller

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 270:G887-G896

Fluorescence microscopy and video image analysis were used to study the transport of a fluorescent bile acid derivative [N-[7-(4-nitrobenzo-2-oxa-1,3-diazol)]-7 beta-amino-3 alpha, 12 alpha-dihydroxy-5 beta-cholan-24-oyl-2-aminoethanesulfonate (NBD-T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb17c30a85daefeeffe393da340eaab
https://doi.org/10.1152/ajpgi.1996.270.6.g887

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¹⁸F-fluoride PET as a noninvasive imaging biomarker for determining treatment efficacy of bone active agents at the hip: a prospective, randomized, controlled clinical study

Autor: Michelle L, Frost, Amelia E, Moore, Musib, Siddique, Glen M, Blake, Didier, Laurent, Babul, Borah, Ursula, Schramm, Marie-Anne, Valentin, Theodore C, Pellas, Paul K, Marsden, Paul J, Schleyer, Ignac, Fogelman

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 28(6)

The functional imaging technique of ¹⁸F-fluoride positron emission tomography (¹⁸F-PET) allows the noninvasive quantitative assessment of regional bone formation at any skeletal site, including the spine and hip. The aim of this study was to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13202337991bb6761c9a0d17537750d4
https://pubmed.ncbi.nlm.nih.gov/23322666

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