Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Ursula R. Kees"'
Autor:
Tina Carter, Maxine Crook, Ashleigh Murch, Alex H. Beesley, Nick de Klerk, Adrian Charles, Ursula R. Kees
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background NUT carcinoma (NC), previously known as NUT midline carcinoma, is a rare and very aggressive cancer that occurs in both children and adults. NC is largely chemoresistant, with an overall survival of less than 7 months. Because the
Externí odkaz:
https://doaj.org/article/ac8e20fd505c4ce596078feda2e43064
Autor:
Laurence C. Cheung, Rebecca de Kraa, Joyce Oommen, Grace-Alyssa Chua, Sajla Singh, Anastasia M. Hughes, Emanuela Ferrari, Jette Ford, Sung K. Chiu, Ronald W. Stam, Ursula R. Kees, Sébastien Malinge, Rishi S. Kotecha
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundInfants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strateg
Externí odkaz:
https://doaj.org/article/5fd90e88f69c4ea7bc73140f8e51d8c1
Autor:
Laurence C. Cheung, Mark N. Cruickshank, Anastasia M. Hughes, Sajla Singh, Grace-Alyssa Chua, Jette Ford, Emanuela Ferrari, Joyce Oommen, Sébastien Malinge, Richard B. Lock, Ursula R. Kees, Rishi S. Kotecha
Publikováno v:
Haematologica, Vol 104, Iss 7 (2019)
Externí odkaz:
https://doaj.org/article/cba2b8faa6fb49ab9ba6b16a74816c84
Autor:
Richard B. Lock, Malcolm A. Smith, Peter J. Houghton, Ursula R. Kees, Raushan T. Kurmasheva, Rosemary Sutton, Michelle Henderson, Rolf Marschalek, Nicola C. Venn, Claus Meyer, Alissa Robbins, Agnes Mendomo, Laura High, Kathryn Evans, Hernan Carol, Jennifer Richmond
Purpose: Although the overall cure rate for pediatric acute lymphoblastic leukemia (ALL) approaches 90%, infants with ALL harboring translocations in the mixed-lineage leukemia (MLL) oncogene (infant MLL-ALL) experience shorter remission duration and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bf87e6335e7a7822cde679b3f889a5
https://doi.org/10.1158/1078-0432.c.6523841.v1
https://doi.org/10.1158/1078-0432.c.6523841.v1
Autor:
Richard B. Lock, Malcolm A. Smith, Peter J. Houghton, Ursula R. Kees, Raushan T. Kurmasheva, Rosemary Sutton, Michelle Henderson, Rolf Marschalek, Nicola C. Venn, Claus Meyer, Alissa Robbins, Agnes Mendomo, Laura High, Kathryn Evans, Hernan Carol, Jennifer Richmond
This file contains Supplementary Methods describing the Pediatric Preclinical Testing Program (PPTP) scoring method. Supplementary Figure S1: Engraftment rates and organ infiltration of MLL-ALL xenografts. Supplementary Figure S2: Comparison of expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e93c2b703ef1ac3f697bc47daba6b25
https://doi.org/10.1158/1078-0432.22458131
https://doi.org/10.1158/1078-0432.22458131
Autor:
Richard B. Lock, Glenn M. Marshall, Ursula R. Kees, Jette Ford, Jane E. Bardell, Rachael A. Papa, Rosemary Gorman, Petra S. Bachmann
Supplementary Figure 1 from Divergent Mechanisms of Glucocorticoid Resistance in Experimental Models of Pediatric Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c4aec69f68e94064be16f7792368c0
https://doi.org/10.1158/0008-5472.22370843.v1
https://doi.org/10.1158/0008-5472.22370843.v1
Autor:
Richard B. Lock, Glenn M. Marshall, Ursula R. Kees, Jette Ford, Jane E. Bardell, Rachael A. Papa, Rosemary Gorman, Petra S. Bachmann
Cell line models of glucocorticoid resistance in childhood acute lymphoblastic leukemia (ALL) almost invariably exhibit altered glucocorticoid receptor (GR) function. However, these findings are incongruous with those using specimens derived directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bad29eb189daaa78c85badd3d4a2ab
https://doi.org/10.1158/0008-5472.c.6496553
https://doi.org/10.1158/0008-5472.c.6496553
Autor:
Ursula R. Kees, Jette Ford, Amy L. Samuels, Denise Anderson, Martin J. Firth, Alex H. Beesley
Patients relapsing with T-cell acute lymphoblastic leukemia (T-ALL) face a dismal outcome. The aim of this study was to identify new markers of drug resistance and clinical response in T-ALL. We measured gene expression and drug sensitivity in 15 ped
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28a377a32eda6df9a0ded304a0b16393
https://doi.org/10.1158/0008-5472.c.6505596
https://doi.org/10.1158/0008-5472.c.6505596
Autor:
Richard B. Lock, Michelle J. Henderson, Angelika Bongers, Tim Failes, Mawar Karsa, Anna Mariana, Laurence C. Cheung, Andrew J. Gifford, Angelika Kosciolek, Michelle Haber, Ursula R. Kees, Rosemary Sutton, Greg M. Arndt, Murray D. Norris, Klaartje Somers, Rishi S. Kotecha
Publikováno v:
Br J Cancer
BACKGROUND: The prognosis for high-risk childhood acute leukaemias remains dismal and established treatment protocols often cause long-term side effects in survivors. This study aims to identify more effective and safer therapeutics for these patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b97d655faa439d099081f3de742cbe
https://doi.org/10.1038/s41416-021-01332-x
https://doi.org/10.1038/s41416-021-01332-x
Autor:
Laurence C. Cheung, Carlos Aya-Bonilla, Mark N. Cruickshank, Sung K. Chiu, Vincent Kuek, Denise Anderson, Grace-Alyssa Chua, Sajla Singh, Joyce Oommen, Emanuela Ferrari, Anastasia M. Hughes, Jette Ford, Elena Kunold, Maria C. Hesselman, Frederik Post, Kelly E. Faulk, Erin H. Breese, Erin M. Guest, Patrick A. Brown, Mignon L. Loh, Richard B. Lock, Ursula R. Kees, Rozbeh Jafari, Sébastien Malinge, Rishi S. Kotecha
Publikováno v:
Leukemia.
Infants with KMT2A-rearranged B-cell acute lymphoblastic leukemia (ALL) have a dismal prognosis. Survival outcomes have remained static in recent decades despite treatment intensification and novel therapies are urgently required. KMT2A-rearranged in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3511827709e3b75fa6fcbd43736a54e
https://pubmed.ncbi.nlm.nih.gov/36380143
https://pubmed.ncbi.nlm.nih.gov/36380143