Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ursula Ptok"'
Publikováno v:
Dementia and Geriatric Cognitive Disorders. 18:151-158
Objective: The familial aggregation of late-onset Alzheimer’s disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD
Autor:
Wolfgang Maier, Reinhard Heun, Ursula Ptok, Ralf G.M. Schlösser, Marie Luise Rao, Heike Kölsch, S. Brune, A. Schulz, Michael Majores
Publikováno v:
Journal of Neural Transmission. 110:1041-1050
The peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a member of the steroid hormone super family of ligand-inducible transcription factors, involved in glucose and lipid metabolism. We screened for polymorphisms in the PPAR-alpha gen
Autor:
Karin Becker, Katharina Bürger, Wolfgang Maier, Frank Jessen, Andreas Papassotiropoulos, Reinhard Heun, Hans-Jürgen Möller, Metin Bagli, Marie Luise Rao, Ursula Ptok, Harald Hampel
Publikováno v:
European Archives of Psychiatry and Clinical Neuroscience. 253:44-48
Interleukin-6 (IL-6) is a multifunctional cytokine involved in the pathogenesis of Alzheimer's disease (AD). The effects of IL-6 are mediated through a specific receptor complex made up of a ligand binding glycoprotein (gp80 or IL-6R) and a signal tr
Publikováno v:
European psychiatry (Ed. Española). 10:20-25
ResumenLos pacientes con enfermedad de Alzheimer (EA) acuden a consulta a menudo por depresión mayor concurrente (DM). Para investigar las razones para esta comorbilidad, por ejemplo, que la DM sea un factor de riego para la EA o que ambos diagnóst
Autor:
Dieter Lütjohann, Wolfgang Maier, Frank Jessen, Reinhard Heun, Michael Ludwig, Marie Luise Rao, A Schulte, K. von Bergmann, Heike Kölsch, Ursula Ptok
Publikováno v:
Molecular Psychiatry. 7:899-902
Cholesterol and 24S-hydroxycholesterol are involved in the pathogenesis of Alzheimer's disease (AD). Increased serum cholesterol concentrations have been detected in patients with AD. 24S-Hydroxycholesterol is the primary cholesterol elimination prod
Publikováno v:
European Psychiatry. 17:254-258
SummaryAlzheimer’s disease (AD) patients often present with concurrent major depression (MD). To investigate the reasons for this comorbidity, e.g. MD being a risk factor for AD, or both diagnoses having a common neurobiology, the temporal relation
Autor:
Andreas Papassotiropoulos, Reinhard Heun, Martin Kockler, Wolfgang Maier, A. Nitardy, Ursula Ptok
Publikováno v:
International Journal of Geriatric Psychiatry. 17:335-342
BACKGROUND: Genetic risk factors are important in Alzheimer's disease (AD). These risk factors might also predispose for other disorders. This might lead to a familial coaggregation of AD and other disorders, e.g. Down's syndrome or Parkinson's disea
Autor:
Frank Jessen, Metin Bagli, Dieter Lütjohann, Ingemar Björkhem, S Locatelli, R Buschfort, Reinhard Heun, K. von Bergmann, Andreas Papassotiropoulos, Ursula Ptok
Publikováno v:
Journal of Psychiatric Research. 36:27-32
The brain is the most cholesterol-rich organ in the human body. Accumulation of excess cholesterol in hippocampal neurons promotes the cleavage of the amyloid precursor protein (APP) into amyloidogenic components with the consequence of the accelerat
Publikováno v:
European psychiatry (Ed. Española). 8:378-383
ResumenLos nacimientos en invierno se han asociado con un riesgo más elevado de enfermedad de Alzheimer (EA) y otros trastornos psiquiátricos. En la presente investigación, se examinó esta asociación putativa en una muestra de pacientes gerontop
Publikováno v:
International Psychogeriatrics. 12:445-451
Background: Advanced parental age has been suggested as a risk factor for Alzheimer's disease (AD) as well as for other psychiatric disorders. In the present investigation, a sample of gerontopsychiatric patients was examined for a possible parental