Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Ursula Liebl"'
Autor:
Jonathan Filée, Hubert F. Becker, Lucille Mellottee, Rima Zein Eddine, Zhihui Li, Wenlu Yin, Jean-Christophe Lambry, Ursula Liebl, Hannu Myllykallio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Asgard archaea include the closest known archaeal relatives of eukaryotes. Here, the authors provide evidence that eukaryotic and Asgard thymidylate synthases (required for DNA synthesis) may have a bacterial origin, and additional lateral transfer o
Externí odkaz:
https://doaj.org/article/5a94de8dfcf84a1fa8bead9006dbbaad
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Carbon monoxide has been recognized relatively recently as signaling molecule, and only very few dedicated natural CO sensor proteins have been identified so far. These include in particular heme-based transcription factors: the bacterial sensor prot
Externí odkaz:
https://doaj.org/article/c9a76933309849269168f7fd90ee19a4
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Comparative genome analyses have led to the discovery and characterization of novel flavin- and folate-dependent methyltransferases that mainly function in DNA precursor synthesis and post-transcriptional RNA modification by forming (ribo) thymidylat
Externí odkaz:
https://doaj.org/article/5adcdf3ed39e45338e22456917c4db91
Autor:
Andreea Sodolescu, Cyril Dian, Laurent Terradot, Latifa Bouzhir-Sima, Roxane Lestini, Hannu Myllykallio, Stéphane Skouloubris, Ursula Liebl
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208850 (2018)
Serine hydroxymethyltransferase (SHMT), encoded by the glyA gene, is a ubiquitous pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the formation of glycine from serine. The thereby generated 5,10-methylene tetrahydrofolate (MTHF) is a maj
Externí odkaz:
https://doaj.org/article/948ddc00bab64642a468e1771d278205
Autor:
Stéphane Skouloubris, Kamel Djaout, Isabelle Lamarre, Jean-Christophe Lambry, Karine Anger, Julien Briffotaux, Ursula Liebl, Hilde de Reuse, Hannu Myllykallio
Publikováno v:
Open Biology, Vol 5, Iss 6 (2015)
ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacteria
Externí odkaz:
https://doaj.org/article/72786186d0a9436da8dd64ed0d2101d5
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47318 (2012)
BACKGROUND: 5-fluorouracil, a commonly used chemotherapeutic agent, up-regulates expression of human thymidylate synthase (hTS). Several different regulatory mechanisms have been proposed to mediate this up-regulation in distinct cell lines, but thei
Externí odkaz:
https://doaj.org/article/0f455a5cf5fa4b8db75c95899f325800
Autor:
Tamara Basta, Yap Boum, Julien Briffotaux, Hubert F. Becker, Isabelle Lamarre-Jouenne, Jean-Christophe Lambry, Stephane Skouloubris, Ursula Liebl, Marc Graille, Herman van Tilbeurgh, Hannu Myllykallio
Publikováno v:
Open Biology, Vol 2, Iss 10 (2012)
Nature has established two mechanistically and structurally unrelated families of thymidylate synthases that produce de novo thymidylate or dTMP, an essential DNA precursor. Representatives of the alternative flavin-dependent thymidylate synthase fam
Externí odkaz:
https://doaj.org/article/f992c67499fc405c97a0c7d9e882a271
Publikováno v:
The Journal of Physical Chemistry B. 126:3199-3207
Flavins are highly versatile redox-active and colored cofactors in a large variety of proteins. These do include photoenzymes and photoreceptors, although the vast majority performs non-light-driven physiological functions. Nevertheless, electron tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4caac2c300d1d55a4a2528d3510bbe
https://doi.org/10.1021/acs.jpcb.2c00969
https://doi.org/10.1021/acs.jpcb.2c00969
Autor:
Jonathan Filée, Hubert F. Becker, Lucille Mellottee, Rima Zein Eddine, Zhihui Li, Wenlu Yin, Jean-Christophe Lambry, Ursula Liebl, Hannu Myllykallio
Publikováno v:
Nature Communications
Nature Communications, 2023, ⟨10.1038/s41467-023-36487-z⟩
Nature Communications, 2023, ⟨10.1038/s41467-023-36487-z⟩
International audience; Asgard archaea include the closest known archaeal relatives of eukaryotes. Here, we investigate the evolution and function of Asgard thymidylate synthases and other folate-dependent enzymes required for the biosynthesis of DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfd3ccc7c2ce5bb0b99762b2b1d897c
https://cnrs.hal.science/hal-03996793/file/s41467-023-36487-z-1.pdf
https://cnrs.hal.science/hal-03996793/file/s41467-023-36487-z-1.pdf
Autor:
Sofia M. Kapetanaki, Zsuzsanna Fekete, Pierre Dorlet, Marten H. Vos, Ursula Liebl, Andras Lukacs
Publikováno v:
Biophys J
Biophysical Journal
Biophysical Journal, 2022, 121, pp.2135-2151. ⟨10.1016/j.bpj.2022.04.031⟩
Biophysical Journal
Biophysical Journal, 2022, 121, pp.2135-2151. ⟨10.1016/j.bpj.2022.04.031⟩
International audience; Heme has been shown to have a crucial role in the signal transduction mechanism of the facultative photoheterotrophic bacterium Rhodobacter sphaeroides. It interacts with the transcriptional regulatory complex AppA/PpsR, in wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e7baa5a5d92f7504161cb3f48f6a90
https://europepmc.org/articles/PMC9247481/
https://europepmc.org/articles/PMC9247481/