Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ursula Koppenhoefer"'
Autor:
Heike Grassmé, Florian Lang, Erich Gulbins, Ursula Koppenhoefer, Birgit Brenner, J. F. J. Kun
Publikováno v:
FEBS Letters. 417:301-306
The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocyte
Autor:
Caroline Müller, Florian Lang, Ursula Koppenhoefer, Erich Gulbins, Albrecht Lepple-Wienhues, Christian-P. Speer, Birgit Brenner, Heike Grassmé
Publikováno v:
Biochemical and Biophysical Research Communications. 239:11-17
The activation of B-lymphocytes depends critically on the interaction of the CD40 receptor with its ligand. Here, we provide evidence that the CD40 ligand (CD40L) also functions as a direct stimulatory molecule for T-lymphocytes. Activation of T-lymp
Publikováno v:
FEBS Letters. 414:444-448
Recent results suggest an activation of T-lymphocytes via the CD40L implying a dual function of this ligand involved in the activation of both B- and T-lymphocytes [1–4]. Here, we provide evidence that activation of T-lymphocytes via CD40L results
Autor:
Birgit Brenner, Ursula Koppenhoefer, Christoph Weinstock, Erich Gulbins, Otwin Linderkamp, Florian Lang
Publikováno v:
Journal of Biological Chemistry. 272:22173-22181
In the present study, we show that Fas receptor ligation or cellular treatment with synthetic C6-ceramide results in activation or phosphorylation, respectively, of the small G-protein Rac1, Jun N-terminal kinase (JNK)/p38 kinases (p38-K), and the tr
Autor:
Gillian L. Busch, Birgit Brenner, Erich Gulbins, Florian Lang, Ursula Koppenhoefer, Otwin Linderkamp
Publikováno v:
Biochemical and Biophysical Research Communications. 231:802-807
L-selectin mediated adhesion to endothelial cells is a crucial step in the immune response to pathogens (1, 2) and in lymphocyte homing (3, 4). Selectin molecules mediate leukocyte rolling on endothelial cells, the initial step of adhesion (5, 6). We
Publikováno v:
Scopus-Elsevier
Selectin-mediated rolling of leukocytes on endothelial cells is the first step in the recruitment of leukocytes to sites of inflammation and seems to be a necessary prerequisite for β2-inte
Autor:
Ursula Koppenhoefer, Christina Pfannenberg, Nisar P. Malek, Tanja Auth, Julia B. Sturm, Michael Bitzer, Tony Yu, Joerg Glatzle, Robert Moehle, M Zimmermann, Alfred Koenigsrainer, Falko Fend, Ulrich M. Lauer, Aladar A. Szalay
Publikováno v:
Journal of Clinical Oncology. 31:3098-3098
3098 Background: For therapy-resistant peritoneal carcinomatosis (PC) viruses exhibiting oncolytic properties open up new perspectives. Our phase I/II study in patients with refractory PC (NCT01443260) is designed to assess the safety, MTD, and anti-
Publikováno v:
Pediatric Research. 41:9-9
Autor:
Michael Weller, Klaus Ferlinz, Florian Lang, Brigit Brenner, Erich Gulbins, Johannes Dichgans, Konrad Sandhoff, Ursula Koppenhoefer, Heike Grassmé
Publikováno v:
Scopus-Elsevier
Fas/CD95/Apo-I has been shown to stimulate a variety of molecules including several members of the caspase family and the acidic sphingomyelinase (Martin and Green 1995; Gulbins et al, 1995). Here, we demonstrate that Fas receptor-triggered activatio
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