Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Ursula J Buchholz"'
Autor:
Christine E Nelson, Taylor W Foreman, Eduardo R Fukutani, Keith D Kauffman, Shunsuke Sakai, Joel D Fleegle, Felipe Gomez, NIAID/DIR Tuberculosis Imaging Program, Sydnee T Gould, Cyril Le Nouën, Xueqiao Liu, Tracey L Burdette, Nicole L Garza, Bernard A P Lafont, Kelsie Brooks, Cecilia S Lindestam Arlehamn, Daniela Weiskopf, Alessandro Sette, Heather D Hickman, Ursula J Buchholz, Reed F Johnson, Jason M Brenchley, James P Oberman, Artur T L Quieroz, Bruno B Andrade, Laura E Via, Daniel L Barber
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012339 (2024)
The regulation of inflammatory responses and pulmonary disease during SARS-CoV-2 infection is incompletely understood. Here we examine the roles of the prototypic pro- and anti-inflammatory cytokines IFNγ and IL-10 using the rhesus macaque model of
Externí odkaz:
https://doaj.org/article/4f2fca22c4d14a298492237eba187e8e
Autor:
Megan Levy, Jessica W Chen, Jaclyn A Kaiser, Hong-Su Park, Xueqiao Liu, Lijuan Yang, Celia Santos, Ursula J Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012198 (2024)
Respiratory syncytial virus (RSV) is the most important viral agent of severe pediatric respiratory illness worldwide, but there is no approved pediatric vaccine. Here, we describe the development of the live-attenuated RSV vaccine candidate Min AL a
Externí odkaz:
https://doaj.org/article/0125f493245a43bd86c11a2816ec7e68
Autor:
Judith Alamares-Sapuay, Michael Kishko, Charles Lai, Mark Parrington, Simon Delagrave, Richard Herbert, Ashley Castens, Joanna Swerczek, Cindy Luongo, Lijuan Yang, Peter L Collins, Ursula J Buchholz, Linong Zhang
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301773 (2024)
Respiratory syncytial virus (RSV) is the leading viral cause of bronchiolitis and pneumonia in infants and toddlers, but there currently is no licensed pediatric vaccine. A leading vaccine candidate that has been evaluated for intranasal immunization
Externí odkaz:
https://doaj.org/article/8dee793b20854a9dbc14b0665ee4ef7f
Autor:
Li Ou, Steven J Chen, I-Ting Teng, Lijuan Yang, Baoshan Zhang, Tongqing Zhou, Andrea Biju, Cheng Cheng, Wing-Pui Kong, Nicholas C Morano, Erik-Stephane D Stancofski, John-Paul Todd, Yaroslav Tsybovsky, Shuishu Wang, Cheng-Yan Zheng, John R Mascola, Lawrence Shapiro, Ruth A Woodward, Ursula J Buchholz, Peter D Kwong
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011584 (2023)
The Pneumoviridae family of viruses includes human metapneumovirus (HMPV) and respiratory syncytial virus (RSV). The closely related Paramyxoviridae family includes parainfluenza viruses (PIVs). These three viral pathogens cause acute respiratory tra
Externí odkaz:
https://doaj.org/article/fd9c2d280940481c856c94d7c813316a
Autor:
Xueqiao Liu, Hong-Su Park, Yumiko Matsuoka, Celia Santos, Lijuan Yang, Cindy Luongo, Ian N Moore, Reed F Johnson, Nicole L Garza, Peng Zhang, Paolo Lusso, Sonja M Best, Ursula J Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011057 (2023)
The pediatric live-attenuated bovine/human parainfluenza virus type 3 (B/HPIV3)-vectored vaccine expressing the prefusion-stabilized SARS-CoV-2 spike (S) protein (B/HPIV3/S-2P) was previously evaluated in vitro and in hamsters. To improve its immunog
Externí odkaz:
https://doaj.org/article/eb32882f2f894b40aeab331f51b202e1
Autor:
Jessica W Chen, Lijuan Yang, Celia Santos, Sergio A Hassan, Peter L Collins, Ursula J Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010191 (2021)
Recoding viral genomes by introducing numerous synonymous nucleotide substitutions that create suboptimal codon pairs provides new live-attenuated vaccine candidates. Because recoding typically involves a large number of nucleotide substitutions, the
Externí odkaz:
https://doaj.org/article/8c178583c7004955bec99733a25f6037
Autor:
Matthias Lingemann, Thomas McCarty, Xueqiao Liu, Ursula J Buchholz, Sonja Surman, Scott E Martin, Peter L Collins, Shirin Munir
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007963 (2019)
Human respiratory syncytial virus (RSV) is the leading viral cause of acute pediatric lower respiratory tract infections worldwide, with no available vaccine or effective antiviral drug. To gain insight into virus-host interactions, we performed a ge
Externí odkaz:
https://doaj.org/article/46667f6db9084bb9983f735f0e03ea55
Autor:
Masfique Mehedi, Thomas McCarty, Scott E Martin, Cyril Le Nouën, Eugen Buehler, Yu-Chi Chen, Margery Smelkinson, Sundar Ganesan, Elizabeth R Fischer, Linda G Brock, Bo Liang, Shirin Munir, Peter L Collins, Ursula J Buchholz
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006062 (2016)
Human respiratory syncytial virus (RSV) is an enveloped RNA virus that is the most important viral cause of acute pediatric lower respiratory tract illness worldwide, and lacks a vaccine or effective antiviral drug. The involvement of host factors in
Externí odkaz:
https://doaj.org/article/f1b2abcfed104beeafe98c4990482e0c
Autor:
Farah El Najjar, Nicolás Cifuentes-Muñoz, Jing Chen, Haining Zhu, Ursula J Buchholz, Carole L Moncman, Rebecca Ellis Dutch
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005922 (2016)
Paramyxovirus spread generally involves assembly of individual viral particles which then infect target cells. We show that infection of human bronchial airway cells with human metapneumovirus (HMPV), a recently identified paramyxovirus which causes
Externí odkaz:
https://doaj.org/article/28e3a109a8e5412c8a2364c9760af8ee
Autor:
Sunil K Khattar, Baibaswata Nayak, Shin-Hee Kim, Sa Xiao, Sweety Samal, Anandan Paldurai, Ursula J Buchholz, Peter L Collins, Siba K Samal
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75456 (2013)
Avian paramyxoviruses (APMV) serotypes 1-9 are frequently isolated from domestic and wild birds worldwide. APMV-1 (also called Newcastle disease virus, NDV) is attenuated in non-human primates and is being developed as a candidate human vaccine vecto
Externí odkaz:
https://doaj.org/article/c6f36dcdb9cc4019b5c7b77a96d99308