Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ursula E. Schoeberl"'
Autor:
Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. He
Externí odkaz:
https://doaj.org/article/7e8a67d729464111a78e5ef9b1dc0236
Autor:
Lisa-Marie Appel, Vedran Franke, Melania Bruno, Irina Grishkovskaya, Aiste Kasiliauskaite, Tanja Kaufmann, Ursula E. Schoeberl, Martin G. Puchinger, Sebastian Kostrhon, Carmen Ebenwaldner, Marek Sebesta, Etienne Beltzung, Karl Mechtler, Gen Lin, Anna Vlasova, Martin Leeb, Rushad Pavri, Alexander Stark, Altuna Akalin, Richard Stefl, Carrie Bernecky, Kristina Djinovic-Carugo, Dea Slade
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Here the authors identify PHF3 SPOC domain as a reader of the phosphorylated RNA polymerase II (Pol II) C-terminal domain. They show that PHF3 clusters with Pol II complexes in cells, drives phase separation of Pol II in vitro, and regulates neuronal
Externí odkaz:
https://doaj.org/article/248ef7e0ffd543019b8945fa5bb593d6
Autor:
Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca2f9f2410fc9104796be93eee4e079
https://doi.org/10.1101/2023.03.31.535086
https://doi.org/10.1101/2023.03.31.535086
Autor:
Ursula E. Schoeberl, Mihaela Peycheva, Tobias Neumann, Daniel Malzl, Rushad Pavri, Mariia Nazarova
Publikováno v:
Science (New York, N.Y.). 377(6612)
Chromosomal translocations result from the joining of DNA double-strand breaks (DSBs) and frequently cause cancer. However, the steps linking DSB formation to DSB ligation remain undeciphered. We report that DNA replication timing (RT) directly regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da79eddbd0f79fd83333468502c7e920
https://pubmed.ncbi.nlm.nih.gov/36108000
https://pubmed.ncbi.nlm.nih.gov/36108000
Autor:
Julia Costea, Ursula E. Schoeberl, Daniel Malzl, Maximilian von der Linde, Johanna Fitz, Ankit Gupta, Marina Makharova, Anton Goloborodko, Rushad Pavri
Publikováno v:
Molecular Cell. 83:681-697.e7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a2207731552ecadbd3ad2d828c8123
https://doi.org/10.1016/j.molcel.2023.01.014
https://doi.org/10.1016/j.molcel.2023.01.014
Autor:
Ursula E. Schoeberl, Johanna Fitz, Kimon Froussios, Renan Valieris, Iordanis Ourailidis, Marina Makharova, Bernd Bauer, Tobias Neumann, Eva-Maria Wiedemann, Monika Steininger, Adriana Cantoran Garcia, Marialaura Mastrovito, Hugo Mouquet, Israel Tojal Da Silva, Rushad Pavri
Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA). Transcription is essential for SHM and AID target genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f750038b8e6c0df818c77b19b242ec
https://doi.org/10.1101/2022.05.21.492925
https://doi.org/10.1101/2022.05.21.492925
Autor:
Julia Costea, Ursula E. Schoeberl, Daniel Malzl, Maximilian von der Linde, Johanna Fitz, Marina Makharova, Anton Goloborodko, Rushad Pavri
Conflicts between transcription and cohesin-mediated loop extrusion can majorly influence 3D chromatin architecture but whether these structural changes affect biological function is unknown. Here, we show that a critical step in antibody class switc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d7652ff41617fe8a7ef7cfd819272e0
https://doi.org/10.1101/2022.04.26.489407
https://doi.org/10.1101/2022.04.26.489407
Autor:
Alexander Athanasiadis, Monika Steininger, Johanna Fitz, Rushad Pavri, Adriana Cantoran Garcia, Eva-Maria Wiedemann, Ursula E. Schoeberl, Tobias Neumann
Publikováno v:
Nature Genetics. 52:505-515
Active enhancers are frequently transcribed, yet the regulatory role of enhancer transcription remains debated. Here, we depleted the RNA polymerase II pausing and elongation factor Spt5 in activated mouse B cells and found that approximately 50% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04f0ba2e9e3c32d021da5495888baf07
https://doi.org/10.1038/s41588-020-0605-6
https://doi.org/10.1038/s41588-020-0605-6
Autor:
Ursula E. Schoeberl, Johanna Fitz, Kimon Froussios, Renan Valieris, Marina Makharova, Iordanis Ourailidis, Bernd Bauer, Tobias Neumann, Eva-Maria Wiedemann, Monika Steininger, Adriana Cantoran Garcia, Marialaura Mastrovito, Hugo Mouquet, Israel Tojal da Silva, Rushad Pavri
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dd5b1c53b042c98e68c9c5cd9881a87
https://doi.org/10.2139/ssrn.4137693
https://doi.org/10.2139/ssrn.4137693
Autor:
Gen Lin, Irina Grishkovskaya, Rushad Pavri, Alexander Stark, Anna Vlasova, Richard Štefl, Ursula E. Schoeberl, Melania Bruno, Carrie Bernecky, Lisa-Marie Appel, Vedran Franke, Martin Leeb, Aiste Kasiliauskaite, Carmen Ebenwaldner, Sebastian Kostrhon, Etienne Beltzung, Kristina Djinović-Carugo, Altuna Akalin, Tanja Kaufmann, Dea Slade, Marek Sebesta, Martin Puchinger, Karl Mechtler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 6078-1-6078-24 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 6078-1-6078-24 (2021)
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks ont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684420fa3a6b9d0b1c365744254e08a1
https://doi.org/10.1038/s41467-021-26360-2
https://doi.org/10.1038/s41467-021-26360-2