Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Ursula Creutzig"'
Autor:
Mareike Rasche, Martin Zimmermann, Emma Steidel, Todd Alonzo, Richard Aplenc, Jean-Pierre Bourquin, Heidrun Boztug, Todd Cooper, Alan S. Gamis, Robert B. Gerbing, Iveta Janotova, Jan-Henning Klusmann, Thomas Lehrnbecher, Nora Mühlegger, Nils v. Neuhoff, Naghmeh Niktoreh, Lucie Sramkova, Jan Stary, Katharina Waack, Christiane Walter, Ursula Creutzig, Michael Dworzak, Gertjan Kaspers, Edward Anders Kolb, Dirk Reinhardt
Publikováno v:
Cancers, Vol 13, Iss 10, p 2336 (2021)
Post-relapse therapy remains critical for survival in children with acute myeloid leukemia (AML). We evaluated survival, response and prognostic variables following relapse in independent cooperative group studies conducted by COG and the population-
Externí odkaz:
https://doaj.org/article/6ccab8b7925f4fe1832f776d8b8301b8
Autor:
Naghmeh Niktoreh, Beate Lerius, Martin Zimmermann, Bernd Gruhn, Gabriele Escherich, Jean-Pierre Bourquin, Michael Dworzak, Lucie Sramkova, Claudia Rossig, Ursula Creutzig, Dirk Reinhardt, Mareike Rasche
Publikováno v:
Haematologica, Vol 104, Iss 1 (2019)
Despite intensified salvage treatments, children with relapsed/refractory acute myeloid leukemia (AML) have poor survival. We evaluated gemtuzumab ozogamicin (CD33-targeted drug) used on a compassionate basis in patients diagnosed from 1995 until 201
Externí odkaz:
https://doaj.org/article/87abc21689c54a8390b3dbb1c975961a
Autor:
Mareike Rasche, Emma Steidel, Martin Zimmermann, Jean-Pierre Bourquin, Heidrun Boztug, Iveta Janotova, E. Anders Kolb, Thomas Lehrnbecher, Nils von Neuhoff, Naghmeh Niktoreh, Nora Mühlegger, Lucie Sramkova, Jan Stary, Christiane Walter, Ursula Creutzig, Michael Dworzak, Dirk Reinhardt
Publikováno v:
Cancers, Vol 13, Iss 4, p 789 (2021)
Successful management of relapse is critical to improve outcomes of children with acute myeloid leukemia (AML). We evaluated response, survival and prognostic factors after a second relapse of AML. Among 1222 pediatric patients of the population-base
Externí odkaz:
https://doaj.org/article/1baebca711d84d67a51adec0cb9cf17a
Autor:
Costa Bachas, Gerrit Jan Schuurhuis, C Michel Zwaan, Marry M van den Heuvel-Eibrink, Monique L den Boer, Eveline S J M de Bont, Zinia J Kwidama, Dirk Reinhardt, Ursula Creutzig, Valérie de Haas, Gertjan J L Kaspers, Jacqueline Cloos
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121730 (2015)
Development of relapse remains a problem for further improvements in the survival of pediatric AML patients. While virtually all patients show a good response to initial treatment, more patients respond poorly when treated at relapse. The cellular ch
Externí odkaz:
https://doaj.org/article/f2c2fd5f271c447aa5b3df572240735c
Autor:
Ursula Creutzig, Martin Zimmermann, Michael N. Dworzak, Brenda Gibson, Rienk Tamminga, Jonas Abrahamsson, Shau-Yin Ha, Henrik Hasle, Alexey Maschan, Yves Bertrand, Guy Leverger, Christine von Neuhoff, Bassem Razzouk, Carmelo Rizzari, Petr Smisek, Owen P. Smith, Batia Stark, Dirk Reinhardt, Gertjan L. Kaspers
Publikováno v:
Haematologica, Vol 99, Iss 9 (2014)
The prognostic significance of early response to treatment has not been reported in relapsed pediatric acute myeloid leukemia. In order to identify an early and easily applicable prognostic factor allowing subsequent treatment modifications, we asses
Externí odkaz:
https://doaj.org/article/1665833acc1248498f4128737c2867b0
Autor:
Mahban Irandoust, Julian Alvarez Zarate, Isabelle Hubeek, Ellen M van Beek, Karin Schornagel, Aart J F Broekhuizen, Mercan Akyuz, Arjan A van de Loosdrecht, Ruud Delwel, Peter J Valk, Edwin Sonneveld, Pamela Kearns, Ursula Creutzig, Dirk Reinhardt, Eveline S J M de Bont, Eva A Coenen, Marry M van den Heuvel-Eibrink, C Michel Zwaan, Gertjan J L Kaspers, Jacqueline Cloos, Timo K van den Berg
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52143 (2013)
BackgroundRecent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, i
Externí odkaz:
https://doaj.org/article/4130b2e000fb4e6db767bbaff246bd5c
Autor:
Jan-Henning Klusmann, Dirk Reinhardt, Martin Zimmermann, Bernhard Kremens, Josef Vormoor, Michael Dworzak, Ursula Creutzig, Thomas Klingebiel
Publikováno v:
Haematologica, Vol 97, Iss 1 (2012)
Background The role of allogeneic stem cell transplantation in post-remission management of children with high-risk acute myeloid leukemia remains controversial. In the multi-center AML-BFM 98 study we prospectively evaluated the impact of allogeneic
Externí odkaz:
https://doaj.org/article/c4f0df33a8d94731a5219f492c510a1d
Autor:
Brian V. Balgobind, Iris H.I.M. Hollink, Susan T.C.J.M. Arentsen-Peters, Martin Zimmermann, Jochen Harbott, H. Berna Beverloo, Anne R.M. von Bergh, Jacqueline Cloos, Gertjan J.L. Kaspers, Valerie de Haas, Zuzana Zemanova, Jan Stary, Jean-Michel Cayuela, Andre Baruchel, Ursula Creutzig, Dirk Reinhardt, Rob Pieters, C. Michel Zwaan, Marry M. van den Heuvel-Eibrink
Publikováno v:
Haematologica, Vol 96, Iss 10 (2011)
Background Several studies of pediatric acute myeloid leukemia have described the various type-I or type-II aberrations and their relationship with clinical outcome. However, there has been no recent comprehensive overview of these genetic aberration
Externí odkaz:
https://doaj.org/article/fcb80d952be8464c97646a8613b1bf99
Autor:
Iris H.I.M. Hollink, Marry M. van den Heuvel-Eibrink, Susan T.C.J.M. Arentsen-Peters, Martin Zimmermann, Justine K. Peeters, Peter J.M. Valk, Brian V. Balgobind, Edwin Sonneveld, Gertjan J.L. Kaspers, Eveline S.J.M. de Bont, Jan Trka, Andre Baruchel, Ursula Creutzig, Rob Pieters, Dirk Reinhardt, C. Michel Zwaan
Publikováno v:
Haematologica, Vol 96, Iss 3 (2011)
Background Dysfunctioning of CCAAT/enhancer binding protein α (C/EBPα) in acute myeloid leukemia can be caused, amongst others, by mutations in the encoding gene (CEBPA) and by promoter hypermethylation. CEBPA-mutated acute myeloid leukemia is asso
Externí odkaz:
https://doaj.org/article/c6cc1fc259804a97b57491fef67a1b85
Autor:
Dorle Messerer, Jutta Engel, Joerg Hasford, Markus Schaich, Gerhard Ehninger, Cristina Sauerland, Thomas Büchner, Andrea Schumacher, Rainer Krahl, Dietger Niederwieser, Jürgen Krauter, Arnold Ganser, Ursula Creutzig, Hartmut Döhner, Richard F. Schlenk
Publikováno v:
Haematologica, Vol 93, Iss 6 (2008)
Background The impact on quality of life of allogeneic stem cell transplantation or conventional chemotherapy in patients with acute myeloid leukemia remains unclear, mainly because of a lack of studies with long-term follow-up. The German AML-Interg
Externí odkaz:
https://doaj.org/article/6de3677511a546629b533ee896ab665c