Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ursula Breyer-Pfaff"'
Autor:
Dorothee Fischer, Ursula Breyer-Pfaff
Publikováno v:
Journal of Pharmacy and Pharmacology. 47:534-538
The activities of β-glucuronidases from Helix pomatia, Escherichia coli and rat towards the N-glucuronides of amitriptyline and diphenhydramine were considerably lower than those towards standard substrates. The two N-glucuronides were analysed in u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc78292644facffc517f4169c6a61610
https://doi.org/10.1111/j.2042-7158.1995.tb05845.x
https://doi.org/10.1111/j.2042-7158.1995.tb05845.x
Autor:
Elfriede Nusser, Brigitte Pfandl, Karl Nill, Ursula Breyer-Pfaff, Michèle Jonzier-Perey, Christian Monney, Pierre Baumann, Dominique Baettig
Publikováno v:
Clinical Pharmacology and Therapeutics. 52:350-358
In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450IIC isozyme, was carried out before amitriptyline th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a6274a486874eaa73e39cb883d9cc8
https://doi.org/10.1038/clpt.1992.155
https://doi.org/10.1038/clpt.1992.155
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 53:502-506
In 18 patients with generalised myasthenia treated with oral pyridostigmine, muscular strength, decrement of neuromuscular transmission in the trapezius muscle on repetitive accessory nerve stimulation, and pyridostigmine plasma level were measured r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dace9b4f56ad7d30ac7bff2cb6b3ce
https://doi.org/10.1136/jnnp.53.6.502
https://doi.org/10.1136/jnnp.53.6.502
Autor:
B Becher, H Wachsmuth, D Zaunbrecher, Elfriede Nusser, Ursula Breyer-Pfaff, B Baier-Weber, A Prox, Karl Nill
Publikováno v:
Xenobiotica. 20:727-738
1. Conjugated metabolites were isolated from the urine of patients receiving amitriptyline treatment using a combination of solid-phase extraction, h.p.l.c. and t.l.c. 2. By n.m.r. and mass spectrometry, N-glucuronides of E- and Z-10-hydroxyamitripty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55cd86de4a9f0335ffd9f7022d59373
https://doi.org/10.3109/00498259009046888
https://doi.org/10.3109/00498259009046888
Autor:
Simone Venz, Simone Block, Vladimír Wsól, Edmund Maser, Hans-Jörg Martin, Ursula Breyer-Pfaff
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 34(3)
Members of the aldo-keto reductase (AKR) superfamily have a broad substrate specificity in catalyzing the reduction of carbonyl group-containing xenobiotics. In the present investigation, a member of the aldose reductase subfamily, AKR1B10, was purif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a635faa21f83c0952361a92e96f4731
https://pubmed.ncbi.nlm.nih.gov/16381663
https://pubmed.ncbi.nlm.nih.gov/16381663
Autor:
Ursula Breyer-Pfaff
Publikováno v:
Drug metabolism reviews. 36(3-4)
Amitriptyline (AT), the most widely used tricyclic antidepressant, undergoes oxidative metabolism in the side chain with production of the secondary amine nortriptyline (NT), a primary amine, and the N-oxide amitriptylinoxide (AT-NO); in addition, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c488623cc3eb906291ac67c3027cbdcb
https://pubmed.ncbi.nlm.nih.gov/15554244
https://pubmed.ncbi.nlm.nih.gov/15554244
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(9)
Detoxication of the tobacco-specific carcinogen 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in humans is mainly due to carbonyl reduction to the chiral alcohol 4-methylnitrosamino-1-(3-pyridyl)-1-butanol (NNAL), which undergoes glucuronidation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc6d26c13c574670a5375ff65c12f779
https://pubmed.ncbi.nlm.nih.gov/15319331
https://pubmed.ncbi.nlm.nih.gov/15319331
Autor:
Edmund Maser, Ursula Breyer-Pfaff
Publikováno v:
ACS Symposium Series ISBN: 9780841238466
Aldo-Keto Reductases and Toxicant Metabolism
Aldo-Keto Reductases and Toxicant Metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d0dfc6baa166a500bd3a72dac40c856
https://doi.org/10.1021/bk-2003-0865.ch005
https://doi.org/10.1021/bk-2003-0865.ch005
Publikováno v:
Neuro-Psychopharmaka Ein Therapie-Handbuch ISBN: 9783211836477
Als Antidepressiva (der altere Begriff Thymoleptika wird heute nicht mehr verwendet) wird eine Klasse von chemisch unterschiedlichen Medikamenten bezeichnet, die ursprunglich vorwiegend bei Patienten mit depressivem Syndrom eingesetzt wurden, heute a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fff2de8657355facb5c2ca74065fa1da
https://doi.org/10.1007/978-3-7091-6150-0_2
https://doi.org/10.1007/978-3-7091-6150-0_2
Publikováno v:
Neuro-Psychopharmaka Ein Therapie-Handbuch ISBN: 9783211836477
Von den trizyklischen Antidepressiva weisen Desipramin, Nortriptylin und Lofepramin, von den tetrazyklischen Antidepressiva Maprotilin eine uberwiegende Noradrenalin-Wiederaufnahmehemmung auf (Ubersichten: RICHELSON und NELSON 1984, CUSACK et al. 199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::951ae3b6a3eac335039af2edf6b23f38
https://doi.org/10.1007/978-3-7091-6150-0_5
https://doi.org/10.1007/978-3-7091-6150-0_5