Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ursula Bommhardt"'
Autor:
Clemens Cammann, Jonas Kulla, Lüder Wiebusch, Christian Walz, Fang Zhao, Theresa Lowinus, Eylin Topfstedt, Neha Mishra, Petra Henklein, Ursula Bommhardt, Lukas Bossaller, Christian Hagemeier, Dirk Schadendorf, Boris Schmidt, Annette Paschen, Ulrike Seifert
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115635- (2023)
Primary and acquired therapy resistance is a major problem in patients with BRAF-mutant melanomas being treated with BRAF and MEK inhibitors (BRAFI, MEKi). Therefore, development of alternative therapy regimes is still required. In this regard, new d
Externí odkaz:
https://doaj.org/article/a59ff95cf70448d3b0138e944befb1de
Autor:
Theresa Lowinus, Florian H. Heidel, Tanima Bose, Subbaiah Chary Nimmagadda, Tina Schnöder, Clemens Cammann, Ingo Schmitz, Ulrike Seifert, Thomas Fischer, Burkhart Schraven, Ursula Bommhardt
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new th
Externí odkaz:
https://doaj.org/article/58bd27f1c33f445fa05b8617cf253f3b
Autor:
Matthias Kästle, Camilla Merten, Roland Hartig, Carlos Plaza-Sirvent, Ingo Schmitz, Ursula Bommhardt, Burkhart Schraven, Luca Simeoni
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7271 (2022)
Signaling via the TCR, which is initiated by the Src-family tyrosine kinase Lck, is crucial for the determination of cell fates in the thymus. Because of its pivotal role, ablation of Lck results in a profound block of T-cell development. Here, we sh
Externí odkaz:
https://doaj.org/article/551d2a0fdc9c41669a8d33a3d70f7836
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3500 (2019)
In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation of
Externí odkaz:
https://doaj.org/article/32abf667b01449be843106abf98fde11
Autor:
Julio Saez-Rodriguez, Luca Simeoni, Jonathan A Lindquist, Rebecca Hemenway, Ursula Bommhardt, Boerge Arndt, Utz-Uwe Haus, Robert Weismantel, Ernst D Gilles, Steffen Klamt, Burkhart Schraven
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 8, p e163 (2007)
Cellular decisions are determined by complex molecular interaction networks. Large-scale signaling networks are currently being reconstructed, but the kinetic parameters and quantitative data that would allow for dynamic modeling are still scarce. Th
Externí odkaz:
https://doaj.org/article/749b56d893044ac2bdd24a3f9fb493a2
Autor:
Matthias, Kästle, Camilla, Merten, Roland, Hartig, Carlos, Plaza-Sirvent, Ingo, Schmitz, Ursula, Bommhardt, Burkhart, Schraven, Luca, Simeoni
Publikováno v:
International journal of molecular sciences. 23(13)
Signaling via the TCR, which is initiated by the Src-family tyrosine kinase Lck, is crucial for the determination of cell fates in the thymus. Because of its pivotal role, ablation of Lck results in a profound block of T-cell development. Here, we sh
Autor:
Subbaiah Chary Nimmagadda, Tina M. Schnöder, Burkhart Schraven, Ulrike Seifert, Clemens Cammann, Florian H. Heidel, Ingo Schmitz, Tanima Bose, Ursula Bommhardt, Thomas Fischer, Theresa Lowinus
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-13 (2019)
Cell communication and signaling : CCS
Cell communication and signaling : CCS
Background Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic
Publikováno v:
Journal of Cellular Signaling. 1
Autor:
Sven R Quist, Luca Simeoni, Christos C. Zouboulis, Harald Gollnick, Anja Thielitz, Yasaman Mirdamadi, Roland Hartig, Antje Wiede, Ursula Bommhardt, Alexander Goihl, Dirk Reinhold, Eleni Papakonstantinou
Publikováno v:
Molecular and Cellular Endocrinology. 415:32-44
A recent hypothesis suggests that a high glycaemic load diet-associated increase of insulin-like growth factor-1 (IGF-1) and insulin may promote acne by reducing nuclear localization of the forkhead box-O1 (FoxO1) transcription factor via activation
Autor:
Theresa, Lowinus, Florian H, Heidel, Tanima, Bose, Subbaiah Chary, Nimmagadda, Tina, Schnöder, Clemens, Cammann, Ingo, Schmitz, Ulrike, Seifert, Thomas, Fischer, Burkhart, Schraven, Ursula, Bommhardt
Publikováno v:
Cell Communication and Signaling : CCS
Background Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic