Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ursula Bodendorf"'
Autor:
Diane Heiser, Joëlle Rubert, Adeline Unterreiner, Claudine Maurer, Marion Kamke, Ursula Bodendorf, Christopher J. Farady, Ben Roediger, Frédéric Bornancin
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Background The NLRP3 inflammasome is a critical component of sterile inflammation, which is involved in many diseases. However, there is currently no known proximal biomarker for measuring NLRP3 activation in pathological conditions. Protein kinase D
Externí odkaz:
https://doaj.org/article/b34f9244fab24b9282945afea3cea706
Autor:
Andreas Boettcher, Adeline Unterreiner, Muriel Kauffmann, Christopher J. Farady, Jörg Eder, Alice Fruhauf, Ursula Bodendorf, Joëlle Rubert, Diane Heiser, Achim Schlapbach, Frédéric Bornancin, P. Erbel
Publikováno v:
Biochemical and Biophysical Research Communications. 545:177-182
The NLRP3 inflammasome is a critical component of the innate immune response to sterile inflammation. Its regulation involves a priming step, required for up-regulation of inflammasome protagonists and an activation step leading to NLRP3 inflammasome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d43e0df4ed76ae22470c3819c7a4a65
https://doi.org/10.1016/j.bbrc.2021.01.051
https://doi.org/10.1016/j.bbrc.2021.01.051
Autor:
Casey J. N. Mathison, Mihai Azimioara, Christopher Cow, Pascal Rigollier, Ursula Bodendorf, Pierre-Yves Michellys, Victor Nikulin, Daniel Pflieger, Ben Wen, Bo Liu, Samantha Zaharevitz, Trixi Brandl, Danilo Guerini, Daniel R. Beisner, Juraj Velcicky, Robert Epple
Publikováno v:
ACS Med Chem Lett
[Image: see text] SPPL2a (Signal Peptide Peptidase Like 2a) is an intramembrane aspartyl protease engaged in the function of B-cells and dendritic cells. Despite being an attractive target for modulation of the immune system, selective SPPL2a inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e450a59020e27f96fb2b86a4f5342a
https://doi.org/10.1021/acsmedchemlett.9b00044
https://doi.org/10.1021/acsmedchemlett.9b00044
Autor:
Benjamin Sommer, Christopher J. Farady, Joel Alois Rene Tapparel, Ursula Bodendorf, Edward J. Oakeley, Sandro Nuciforo, Sandrine Romand, Stine Buechmann-Moeller, Holger Laux
Publikováno v:
Biotechnology and Bioengineering. 115:2530-2540
An increasing number of nonantibody format proteins are entering clinical development. However, one of the major hurdles for the production of nonantibody glycoproteins is host cell-related proteolytic degradation, which can drastically impact develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a4a0065d1d9f1e857a74dcef8ee85e
https://doi.org/10.1002/bit.26731
https://doi.org/10.1002/bit.26731
Autor:
Roland Feifel, Philip C. Smith, Ursula Bodendorf, Robert Epple, Philippe Couttet, Reiner Aichholz, Danilo Guerini, Ina Dix, Ben Wen, Bo Liu, Peter Wipfli, Juraj Velcicky, Toni Widmer, Trixi Brandl, Daniel R. Beisner, Pascal Rigollier
Publikováno v:
Journal of Medicinal Chemistry. 61:865-880
Signal peptide peptidase-like 2a (SPPL2a) is an aspartic intramembrane protease which has recently been shown to play an important role in the development and function of antigen presenting cells such as B lymphocytes and dendritic cells. In this pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f019f401a7282949702f439bc69e4e37
https://doi.org/10.1021/acs.jmedchem.7b01371
https://doi.org/10.1021/acs.jmedchem.7b01371
Autor:
Marjo Götte, Danilo Guerini, Ansgar Schuffenhauer, Daniela Siebert, Marion Kamke, Ursula Bodendorf, Yvonne Ibig-Rehm, Daniela Gabriel, Xian Zhang, Dan Beisner, Ghislain M. C. Bonamy
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(9)
The intramembrane protease signal peptide peptidase-like 2a (SPPL2a) is a potential drug target for the treatment of autoimmune diseases due to an essential role in B cells and dendritic cells. To screen a library of 1.4 million compounds for inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612b52645289838ac486f1b08e55e349
https://pubmed.ncbi.nlm.nih.gov/28731783
https://pubmed.ncbi.nlm.nih.gov/28731783
Autor:
Bruno Martoglio, Michael Young, Sherry Niessen, Petra Langerak, Michael P. Cooke, Daniel R. Beisner, Carol Dahlberg, S. Sutton, Benjamin F. Cravatt, Albert E. Parker, Ursula Bodendorf, Tim Wiltshire, Whitney Barnes, Francella Otero, Laurent Poirot
Publikováno v:
The Journal of Experimental Medicine
The protease Sppl2a cleaves the N-terminal fragment of invariant chain (CD74) and is required for efficient B cell development and function.
B cell development requires tight regulation to allow for the generation of a diverse repertoire while p
B cell development requires tight regulation to allow for the generation of a diverse repertoire while p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db8cd2a3df60b5f6449a15af6a4194a
http://europepmc.org/articles/PMC3549714
http://europepmc.org/articles/PMC3549714
Publikováno v:
BMC Proceedings
Background Chinese hamster ovary (CHO) cells are the most widely used host for large scale production of recombinant therapeutic proteins. A combination of several gene editing approaches applied to Novartis proprietary CHO cell line resulted in a su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435c7747880021c4b1c265031b1a31b3
https://doi.org/10.1186/1753-6561-9-s9-p17
https://doi.org/10.1186/1753-6561-9-s9-p17
Autor:
Thomas Marbury, Steven J. Kovacs, Jay Parthiban Lakshman, Kelly A. Wong, Marjorie Ison, Prakash Raman, Kristina Dabovic, Ursula Bodendorf, Kathryn Rene Bracken, Darlene Chen, Bin Li, Weidong Zhong, Richard Colvin, Eric Lawitz, Sanjeev Thohan, Erica Canino, Avantika Barve, Mohamed Bidair, Baldur Magnusson, Catherine L. Jones, Tycho Heimbach, Rachael Steiner-Swiat, Christopher T. Jones, David T. Barkan
Publikováno v:
Clinical Therapeutics. 40:1567-1581.e4
Purpose Infection with hepatitis C virus is the leading cause of infectious disease mortality in the United States. BZF961 is a novel small molecule inhibitor of the hepatitis C virus NS3-4A protease. Here we present the results of a randomized, doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdfa07688ce19598b6389ed797456d8
https://doi.org/10.1016/j.clinthera.2018.07.019
https://doi.org/10.1016/j.clinthera.2018.07.019
Autor:
A. Hein, P. Erbel, S. Gil-Parrado, A. Bernardi, Ursula Bodendorf, D. Vinzenz, Bernd Gerhartz, C. Logel, A. Mac Sweeney
Publikováno v:
Journal of Molecular Biology. 384:228-239
Procollagen C-peptidase, also known as bone morphogenetic protein 1 (BMP-1), is a multidomain, zinc endopeptidase of the astacin M12A family. BMP-1 is the prototype of a small group of proteases that have key roles in extracellular matrix formation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2816eaa06fe761b7b4f394fe149fad62
https://doi.org/10.1016/j.jmb.2008.09.029
https://doi.org/10.1016/j.jmb.2008.09.029