Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ursula, Storch"'
Autor:
Maximilian Keck, Christian Hermann, Kyra Lützel, Thomas Gudermann, David B. Konrad, Michael Mederos y Schnitzler, Ursula Storch
Publikováno v:
iScience, Vol 27, Iss 10, Pp 111008- (2024)
Summary: The non-selective transient receptor potential canonical 6 (TRPC6) cation channels have several physiological and pathophysiological effects. They are activated by the lipid second messenger diacylglycerol (DAG) and by non-lipidic compounds
Externí odkaz:
https://doaj.org/article/14581ea90ce3437aadfb3f8c9ed4d86c
Autor:
Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos y Schnitzler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing
Externí odkaz:
https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407
Autor:
Trese Leinders-Zufall, Ursula Storch, Michael Mederos y Schnitzler, Navin K. Ojha, Kohei Koike, Thomas Gudermann, Frank Zufall
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100527- (2021)
Summary: Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly gaining widespread recognition for investigations of transient receptor potential canonical (TRPC) channels. This protocol describes the use of three ph
Externí odkaz:
https://doaj.org/article/a971563504d542199dde374703f4cf03
Autor:
Maria K. Schweitzer, MSc, Fabiola Wilting, MSc, Simon Sedej, PhD, Lisa Dreizehnter, PhD, Nathan J. Dupper, BSc, Qinghai Tian, PhD, Alessandra Moretti, PhD, Ilaria My, MD, Ohyun Kwon, PhD, Silvia G. Priori, MD, PhD, Karl-Ludwig Laugwitz, MD, Ursula Storch, PhD, Peter Lipp, PhD, Andreas Breit, PhD, Michael Mederos y Schnitzler, PhD, Thomas Gudermann, MD, Johann Schredelseker, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 737-747 (2017)
Cardiovascular disease-related deaths frequently arise from arrhythmias, but treatment options are limited due to perilous side effects of commonly used antiarrhythmic drugs. Cardiac rhythmicity strongly depends on cardiomyocyte Ca2+ handling and pre
Externí odkaz:
https://doaj.org/article/a17d99e526834f97a47d3d5c80e71635
Publikováno v:
Cells, Vol 7, Iss 11, p 218 (2018)
Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accept
Externí odkaz:
https://doaj.org/article/af38c09b5cce41658b4ed156a8164528
Autor:
Christian Hermann, Aaron Treder, Marius Näher, Roman Geiseler, Thomas Gudermann, Michael Mederos y Schnitzler, Ursula Storch
Publikováno v:
Biophysical journal. 121(8)
The patch-clamp method, which was awarded the Nobel Prize in 1991, is a well-established and indispensable method to study ion channels in living cells and to biophysically characterize non-voltage-gated ion channels, which comprise about 70% of all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13291585862bc6f1a29e86487c54366f
https://pubmed.ncbi.nlm.nih.gov/35300969
https://pubmed.ncbi.nlm.nih.gov/35300969
Autor:
Thomas Gudermann, Ursula Storch, Stefan Offermanns, Laura Danner, Jasmin Becker, Angela Wirth, Nicole Ziegler, Michael Mederos y Schnitzler, Michaela Winter, Serap Erdogmus, Carsten Hoffmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but also serve as mechanosensors involved in various (patho)physiological settings like vascular regulation, cardiac hypertrophy and preeclampsia. However, the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd7c9f2869a2f75d1f73b3355e8f361
https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407
https://doaj.org/article/9fd1442d78534dbea5f8633d29b4f407
Autor:
Serap Erdogmus, Thomas Gudermann, Ursula Storch, Alexander Dietrich, Susanne Fiedler, Michael Mederos y Schnitzler
Publikováno v:
Molecular Pharmacology. 96:90-98
Although the overall structure of many classical transient receptor potential proteins (TRPC), including human and murine TRPC6, were recently resolved by cryoelectron microscopy analysis, structural changes during channel activation by 1-oleoyl-1-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e0ba0405bc4a3eac6cd0a1c59512b3
https://doi.org/10.1124/mol.119.115949
https://doi.org/10.1124/mol.119.115949
Autor:
Ursula Storch, Kohei Koike, Thomas Gudermann, Michael Mederos y Schnitzler, Navin Kumar Ojha, Trese Leinders-Zufall, Frank Zufall
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100527-(2021)
STAR Protocols
STAR Protocols
Summary Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly gaining widespread recognition for investigations of transient receptor potential canonical (TRPC) channels. This protocol describes the use of three pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fe1248c94c4129ff55c8f54df947df
http://www.sciencedirect.com/science/article/pii/S2666166721002343
http://www.sciencedirect.com/science/article/pii/S2666166721002343
Publikováno v:
Cell calcium. 97
The transient receptor potential classical or canonical (TRPC) 5 channel is a non-selective calcium-permeable cation channel that recently emerged as a promising target for the treatment of various diseases such as mental disorders and kidney disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfc54cd4886602931945165ad6f5b66
https://pubmed.ncbi.nlm.nih.gov/33930818
https://pubmed.ncbi.nlm.nih.gov/33930818