Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Ursula, Seidler"'
Autor:
Eleni Roussa, Pavel Juda, Michael Laue, Oliver Mai-Kolerus, Wolfgang Meyerhof, Markus Sjöblom, Katerina Nikolovska, Ursula Seidler, Manfred W. Kilimann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Mutations in LRBA, a BEACH domain protein, cause severe immune deficiency in humans. LRBA is expressed in many tissues and organs according to biochemical analysis, but little is known about its cellular and subcellular localization, and its
Externí odkaz:
https://doaj.org/article/ae20a302c35e4f3284854560398bc7f7
Autor:
Jiraporn Ousingsawat, Raquel Centeio, Nicole Reyne, Alexandra McCarron, Patricia Cmielewski, Rainer Schreiber, Gabriella diStefano, Dorothee Römermann, Ursula Seidler, Martin Donnelley, Karl Kunzelmann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion. In the present study we investigated
Externí odkaz:
https://doaj.org/article/06c1135f56334127a708313a72426579
Autor:
Karl Kunzelmann, Raquel Centeio, Jiraporn Ousingsawat, Khaoula Talbi, Ursula Seidler, Rainer Schreiber
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTSLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the respiratory system, in male tissues and in the skin. SLC26A9 has gaine
Externí odkaz:
https://doaj.org/article/4fe0fe1fe0f14cb381bb1534fce08f9c
Autor:
Archana Kini, Bei Zhao, Marijana Basic, Urmi Roy, Aida Iljazovic, Ivan Odak, Zhenghao Ye, Brigitte Riederer, Gabriella Di Stefano, Dorothee Römermann, Christian Koenecke, André Bleich, Till Strowig, Ursula Seidler
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Genetic defects in SLC26A3 (DRA), an intestinal Cl−/HCO3− exchanger, result in congenital chloride diarrhea (CLD), marked by lifelong acidic diarrhea and a high risk of inflammatory bowel disease. Slc26a3−/− mice serve as a model to understan
Externí odkaz:
https://doaj.org/article/1c64cba46b194950be690c85e4c2c089
Autor:
Lijia Wang, Liping Chen, Xianyuan Wang, Kaiyuan Liu, Ting Li, Yue Yu, Jian Han, Shuai Xing, Jiaxin Xu, Dean Tian, Ursula Seidler, Fang Xiao
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
ObjectiveEvaluation of the endoscopic features of Crohn’s disease (CD) and ulcerative colitis (UC) is the key diagnostic approach in distinguishing these two diseases. However, making diagnostic differentiation of endoscopic images requires precise
Externí odkaz:
https://doaj.org/article/bb09a19f0d304c6d968d4e45d1f641a3
Autor:
Yan Yu, Anna Seidler, Kunyan Zhou, Zhenglin Yuan, Sunil Yeruva, Mahdi Amiri, Chris C. Yun, Katerina Nikolovska, Ursula Seidler
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 5, Pp 1017-1038 (2019)
Externí odkaz:
https://doaj.org/article/ac8457b3f8044a20962b2e8d716205fd
Autor:
Liping Chen, Junhua Li, Zhenghao Ye, Binghua Sun, Lu Wang, Yu Chen, Jian Han, Meiping Yu, Ying Wang, Qi Zhou, Ursula Seidler, De’an Tian, Fang Xiao
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein in mammals. When released into the extracellular space, it acts as a damage-associated molecular pattern. This study investigates whether increased HMGB1 levels are found in the intest
Externí odkaz:
https://doaj.org/article/ce6c0b5c2b6844f89bbc9dfd52978e68
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: Haploinsufficiency A20 (HA20) is a newly described monogenic disease characterized by a wide spectrum of manifestations and caused by heterozygous mutations in TNFAIP3 which encodes A20 protein. TNFAIP3 mutation leads to disruption of the
Externí odkaz:
https://doaj.org/article/f60fe48c6d0540e5b41fb4a19989acab
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Objective: Intestinal Behcet's disease (iBD) is an autoimmune disorder diagnosed by typical intestinal ulcers and systemic Behcet's disease (BD) manifestations. Haploinsufficiency of A20 (HA20) is a recently described autoinflammatory disease with a
Externí odkaz:
https://doaj.org/article/41d6f6004cd249eba2d3792a5e3ca1be
Autor:
Ivan Odak, Alina Depkat-Jakob, Maleen Beck, Michael Jarek, Yan Yu, Ursula Seidler, Sascha David, Arnold Ganser, Reinhold Förster, Immo Prinz, Christian Koenecke
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231222 (2020)
IL-17A and IL-17F cytokines are important regulators of acute graft-versus-host-disease (GVHD). However, contrary effects of these cytokines in inflammatory diseases have been reported. To investigate the effects of donor-derived IL-17A and IL-17F on
Externí odkaz:
https://doaj.org/article/902e691d34d748aebb8fdacb3ce156dd