Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Urska Kamensek"'
Autor:
Bostjan Markelc, Tanja Jesenko, Simona Kranjc Brezar, Masa Omerzel, Ursa Lampreht Tratar, Andrej Rencelj, Urska Matkovic, Katarina Znidar, Spela Kos, Kristina Levpuscek, Ziva Pisljar, Ursa Kesar, Tilen Komel, Tim Bozic, Aneja Tuljak, Rosana Hudej, Matjaz Peterka, Urska Kamensek, Andrej Cör, Gorana Gasljevic, Alenka Nemec Svete, Natasa Tozon, Gregor Sersa, Maja Cemazar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Immunotherapeutic drugs are promising medicines for cancer treatment. A potential candidate for immunotherapy is interleukin-12 (IL-12), a cytokine well known for its ability to mediate antitumor activity. We developed a plasmid encoding hum
Externí odkaz:
https://doaj.org/article/31c16b9fe1ca4c038f2fb6e10cd7146e
Autor:
Marianna Maddaloni, Rossella Farra, Barbara Dapas, Fulvia Felluga, Fabio Benedetti, Federico Berti, Sara Drioli, Mattia Vidali, Maja Cemazar, Urska Kamensek, Claudio Brancolini, Erminio Murano, Francesca Maremonti, Mario Grassi, Alice Biasin, Flavio Rizzolio, Enrico Cavarzerani, Bruna Scaggiante, Roberta Bulla, Andrea Balduit, Giuseppe Ricci, Gabriella Zito, Federico Romano, Serena Bonin, Eros Azzalini, Gabriele Baj, Domenico Tierno, Gabriele Grassi
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 664 (2024)
Background: The identification of novel therapeutic strategies for ovarian cancer (OC), the most lethal gynecological neoplasm, is of utmost urgency. Here, we have tested the effectiveness of the compound 2c (4-hydroxy-2,6-bis(4-nitrobenzylidene)cycl
Externí odkaz:
https://doaj.org/article/9cda9d91d298443aa1fd39a5f208d7da
Autor:
Tinkara Remic, Gregor Sersa, Kristina Levpuscek, Ursa Lampreht Tratar, Katja Ursic Valentinuzzi, Andrej Cör, Urska Kamensek
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and the investigation of the interactions of different modalities. The aim of this study was two-fold. Firstly, to select the most effective combination of
Externí odkaz:
https://doaj.org/article/bde0a6b771fa485f8b52f90d0afe3c43
Autor:
Urska Kamensek, Maja Cemazar, Simona Kranjc Brezar, Tanja Jesenko, Spela Kos, Katarina Znidar, Bostjan Markelc, Ziva Modic, Tilen Komel, Tim Gorse, Eva Rebersek, Helena Jakopic, Gregor Sersa
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1981 (2023)
DNA vaccination is one of the emerging approaches for a wide range of applications, including prophylactic vaccination against infectious diseases and therapeutic vaccination against cancer. The aim of this study was to evaluate the feasibility of ou
Externí odkaz:
https://doaj.org/article/e1458df429704fbe9b25838babe718fb
Publikováno v:
Heliyon, Vol 8, Iss 2, Pp e08879- (2022)
Interleukin 12 (IL-12) is a cytokine used as a therapeutic molecule in cancer immunotherapy. Gene electrotransfer mediated delivery of IL-12 gene has reached clinical evaluation in the USA using a plasmid that in addition to IL-12 gene also carry an
Externí odkaz:
https://doaj.org/article/0af4909cdf6e4175a81c816179e51c84
Autor:
Spela Kos, Masa Bosnjak, Tanja Jesenko, Bostjan Markelc, Urska Kamensek, Katarina Znidar, Urska Matkovic, Andrej Rencelj, Gregor Sersa, Rosana Hudej, Aneja Tuljak, Matjaz Peterka, Maja Cemazar
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1739 (2021)
Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such as gene electrotransfer, which can provide localized delivery
Externí odkaz:
https://doaj.org/article/e0a9f59802f9407ca46068c68fbe54cd
Publikováno v:
Vaccines, Vol 8, Iss 1, p 111 (2020)
Tumor cell-based vaccines use tumor cells as a source of tumor-associated antigens. In our study, we aimed to develop and test a tumor vaccine composed of tumor cells killed by irradiation combined with in vivo interleukin-12 gene electrotransfer as
Externí odkaz:
https://doaj.org/article/d4cdf2be78f5455cb0251808e5d6e3ac
Autor:
Ursa Lampreht Tratar, Luisa Loiacono, Maja Cemazar, Urska Kamensek, Vito Michele Fazio, Gregor Sersa, Emanuela Signori
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Cancer immunotherapy is currently one of the leading approaches in cancer treatment. Gene electrotransfer of plasmids encoding interleukin 12 (IL-12) into the cells leads to the production of IL-12, which drives immune cell polarization to an antitum
Externí odkaz:
https://doaj.org/article/adafbeca0d9c4413bfb7b72f718abbcd
Autor:
Rossella Farra, Matea Maruna, Francesca Perrone, Mario Grassi, Fabio Benedetti, Marianna Maddaloni, Maguie El Boustani, Salvo Parisi, Flavio Rizzolio, Giancarlo Forte, Fabrizio Zanconati, Maja Cemazar, Urska Kamensek, Barbara Dapas, Gabriele Grassi
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 547 (2019)
The unmet need for novel therapeutic options for ovarian cancer (OC) deserves further investigation. Among the different novel drugs, small interfering RNAs (siRNAs) are particularly attractive because of their specificity of action and efficacy, as
Externí odkaz:
https://doaj.org/article/3b375c75ea73465e80818a3b526cc03d
Autor:
Spela Kos, Tanja Blagus, Maja Cemazar, Ursa Lampreht Tratar, Monika Stimac, Lara Prosen, Tanja Dolinsek, Urska Kamensek, Simona Kranjc, Lars Steinstraesser, Gaëlle Vandermeulen, Véronique Préat, Gregor Sersa
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Skin is an attractive target for gene electrotransfer. It consists of different cell types that can be transfected, leading to various responses to gene electrotransfer. We demonstrate that these responses could be controlled by selecting the appropr
Externí odkaz:
https://doaj.org/article/02b918f38a1b42aabd9d9f3e19e00d2b