Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Ursel Soomets"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 3, Pp 2343-2354 (2024)
Increased oxidative stress (OS) and systemic inflammation are key players in the pathophysiology of chronic obstructive pulmonary disease (COPD). We aimed to clarify the effects of synthetic glutathione (GSH) analogue peptides UPF1 and UPF17 on the m
Externí odkaz:
https://doaj.org/article/67b5681ba2cd425ba0c8d0a1ab1e4bf7
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 953 (2024)
To test the hypothesis that they serve as systemic biomarkers of chronic obstructive pulmonary disease (COPD), we profiled the mRNA expression of enzymes connected to systemic inflammation and GSH metabolism in peripheral blood mononuclear cells (PBM
Externí odkaz:
https://doaj.org/article/6f43c269322544eab3e8bdeddd368d04
Autor:
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Silencing of STK25, an STE20-type kinase, in human aortic endothelial and smooth muscle cells reduces lipid accumulation and suppresses inflammation and fibrotic pathways, ultimately exerting atheroprotective effects.
Externí odkaz:
https://doaj.org/article/c671ada46a694cea94aa6e66b65dc4a6
Autor:
Ott Kiens, Egon Taalberg, Viktoria Ivanova, Ketlin Veeväli, Triin Laurits, Ragne Tamm, Aigar Ottas, Kalle Kilk, Ursel Soomets, Alan Altraja
Publikováno v:
ERJ Open Research, Vol 9, Iss 1 (2023)
Background The apnoea–hypopnoea index (AHI) forms the basis for severity of obstructive sleep apnoea (OSA), a condition expected to reprogramme metabolic pathways in humans. We aimed to identify the AHI breakpoint from which the majority of signifi
Externí odkaz:
https://doaj.org/article/e7481e4c4d0849418390c126aa46a092
Autor:
Ott Kiens, Egon Taalberg, Viktoria Ivanova, Ketlin Veeväli, Triin Laurits, Ragne Tamm, Aigar Ottas, Kalle Kilk, Ursel Soomets, Alan Altraja
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract There are no clinical studies that have investigated the differences in blood serum metabolome between obstructive sleep apnea (OSA) patients and controls. In a single-center prospective observational study, we compared metabolomic profiles
Externí odkaz:
https://doaj.org/article/9ab2f606810e46d7a27d8978cc1a1e17
Autor:
Liis Ilves, Aigar Ottas, Bret Kaldvee, Kristi Abram, Ursel Soomets, Mihkel Zilmer, Viljar Jaks, Külli Kingo
Publikováno v:
Acta Dermato-Venereologica, Vol 101, Iss 2, p adv00407 (2021)
The main objectives of this study were to characterize the metabolomic profile of lesional skin of patients with atopic dermatitis, and to compare it with non- lesional skin of patients with atopic dermatitis and skin of controls with no dermatologic
Externí odkaz:
https://doaj.org/article/3bfbf309fb114923bbef3b1b0c936421
Autor:
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the
Externí odkaz:
https://doaj.org/article/76ee7c613d244adda29bbfe316fe4d15
Autor:
Jüri Lieberg, Anders Wanhainen, Aigar Ottas, Mare Vähi, Mihkel Zilmer, Ursel Soomets, Martin Björck, Jaak Kals
Publikováno v:
Metabolites, Vol 11, Iss 8, p 555 (2021)
Abdominal aortic aneurysm (AAA) is characterized by structural deterioration of the aortic wall, leading to aortic dilation and rupture. The aim was to compare 183 low molecular weight metabolites in AAA patients and aorta-healthy controls and to exp
Externí odkaz:
https://doaj.org/article/482b96533f064a138b75de449f2361b2
Autor:
Andres Asser, Sulev Kõks, Ursel Soomets, Anton Terasmaa, Martin Sauk, Mall Eltermaa, Piret Piip, Kumari Ubhayasekera, Jonas Bergquist, Pille Taba
Publikováno v:
Heliyon, Vol 5, Iss 9, Pp e02475- (2019)
An intravenously injectable illicit drug made by mixing pseudoephedrine, potassium permanganate, vinegar and water, yielding methcathinone (Mcat) and manganese (Mn), induces an extrapyramidal syndrome with parkinsonism, dystonia, gait and balance dis
Externí odkaz:
https://doaj.org/article/878fae442e214d2babae374464621985
Publikováno v:
Journal of Chemistry, Vol 2019 (2019)
A glutathione (L-γ-glutamyl-L-cysteinylglycine, GSH) analogue, UPF1 (O-methyl-L-tyrosinylglutathione), has been shown to increase intracellular concentration of total glutahione (tGSH) in K562 cells. The synthesis of GSH is a two-step process that r
Externí odkaz:
https://doaj.org/article/744d07f6ceee4f41a41262600e45a878