Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Ursa Lampreht"'
Autor:
Bostjan Markelc, Tanja Jesenko, Simona Kranjc Brezar, Masa Omerzel, Ursa Lampreht Tratar, Andrej Rencelj, Urska Matkovic, Katarina Znidar, Spela Kos, Kristina Levpuscek, Ziva Pisljar, Ursa Kesar, Tilen Komel, Tim Bozic, Aneja Tuljak, Rosana Hudej, Matjaz Peterka, Urska Kamensek, Andrej Cör, Gorana Gasljevic, Alenka Nemec Svete, Natasa Tozon, Gregor Sersa, Maja Cemazar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Immunotherapeutic drugs are promising medicines for cancer treatment. A potential candidate for immunotherapy is interleukin-12 (IL-12), a cytokine well known for its ability to mediate antitumor activity. We developed a plasmid encoding hum
Externí odkaz:
https://doaj.org/article/31c16b9fe1ca4c038f2fb6e10cd7146e
Autor:
Ursa Lampreht Tratar, Tanja Jesenko, Masa Omerzel, Alenka Seliskar, Urban Stupan, Mihajlo Djokic, Jerneja Sredensek, Blaz Trotovsek, Gregor Sersa, Maja Cemazar
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3151 (2024)
Gene electrotransfer (GET) of plasmids encoding interleukin 12 (IL-12) has already been used for the treatment of various types of tumors in human oncology and as an adjuvant in DNA vaccines. In recent years, we have developed a plasmid encoding huma
Externí odkaz:
https://doaj.org/article/1fc1a60848d04b32b0dea923033161ce
Autor:
Tilen Komel, Masa Omerzel, Urska Kamensek, Katarina Znidar, Ursa Lampreht Tratar, Simona Kranjc Brezar, Klemen Dolinar, Sergej Pirkmajer, Gregor Sersa, Maja Cemazar
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12900 (2023)
Gene immunotherapy has become an important approach in the treatment of cancer. One example is the introduction of genes encoding immunostimulatory cytokines, such as interleukin 2 and interleukin 12, which stimulate immune cells in tumours. The aim
Externí odkaz:
https://doaj.org/article/cdcfbc5fd70d490b8d5251cea50408ca
Autor:
Tinkara Remic, Gregor Sersa, Kristina Levpuscek, Ursa Lampreht Tratar, Katja Ursic Valentinuzzi, Andrej Cör, Urska Kamensek
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and the investigation of the interactions of different modalities. The aim of this study was two-fold. Firstly, to select the most effective combination of
Externí odkaz:
https://doaj.org/article/bde0a6b771fa485f8b52f90d0afe3c43
Publikováno v:
Veterinary Medicine and Science, Vol 6, Iss 3, Pp 290-298 (2020)
Abstract The aim of this study was to evaluate the owners' perception of health‐related quality of life (HRQoL) of dogs after treatment with electrochemotherapy (ECT) alone or combined with interleukin‐12 gene electrotransfer (IL‐12 GET) and/or
Externí odkaz:
https://doaj.org/article/cb3c7af4d724447d9e74cc3fba1b7d91
Autor:
Spela Kos, Alessandra Lopes, Veronique Preat, Maja Cemazar, Ursa Lampreht Tratar, Bernard Ucakar, Kevin Vanvarenberg, Gregor Sersa, Gaelle Vandermeulen
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217762 (2019)
We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 melano
Externí odkaz:
https://doaj.org/article/a51058ce69a64fbf8f44ce52ef40d79c
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
The use of existing mouse models in cancer research is of utmost importance as they aim to explore the casual link between candidate cancer genes and carcinogenesis as well as to provide models to develop and test new therapies. However, faster progr
Externí odkaz:
https://doaj.org/article/41077a2dacda43dcb19d932386b518bd
Autor:
Ursa Lampreht Tratar, Luisa Loiacono, Maja Cemazar, Urska Kamensek, Vito Michele Fazio, Gregor Sersa, Emanuela Signori
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Cancer immunotherapy is currently one of the leading approaches in cancer treatment. Gene electrotransfer of plasmids encoding interleukin 12 (IL-12) into the cells leads to the production of IL-12, which drives immune cell polarization to an antitum
Externí odkaz:
https://doaj.org/article/adafbeca0d9c4413bfb7b72f718abbcd
Autor:
Spela Kos, Tanja Blagus, Maja Cemazar, Ursa Lampreht Tratar, Monika Stimac, Lara Prosen, Tanja Dolinsek, Urska Kamensek, Simona Kranjc, Lars Steinstraesser, Gaëlle Vandermeulen, Véronique Préat, Gregor Sersa
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Skin is an attractive target for gene electrotransfer. It consists of different cell types that can be transfected, leading to various responses to gene electrotransfer. We demonstrate that these responses could be controlled by selecting the appropr
Externí odkaz:
https://doaj.org/article/02b918f38a1b42aabd9d9f3e19e00d2b
Autor:
Natasa Tesic, Urska Kamensek, Gregor Sersa, Simona Kranjc, Monika Stimac, Ursa Lampreht, Veronique Preat, Gaelle Vandermeulen, Miha Butinar, Boris Turk, Maja Cemazar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
Endoglin (CD105), a transforming growth factor (TGF)-β coreceptor, and endothelin-1, a vasoconstrictor peptide, are both overexpressed in tumor endothelial and melanoma cells. Their targeting is therefore a promising therapeutic approach for melanom
Externí odkaz:
https://doaj.org/article/8a4f293de1854b56a574d23ba05e0ed4