Proteomics: From Protein Identification to Biological function

Autor: Jan van Oostrum, Sjouke Hoving, Dieter Müller, Patrick Schindler, Michel Steinmetz, Harry Towbin, Hans Voshol, Urs Wirth

Publikováno v: CHIMIA, Vol 55, Iss 4 (2001)

The term 'proteome' describes the expressed protein complement of a genome. The largely invariant genome of an individual or organism determines its potential for gene- and protein expression but does not specify which proteins are expressed in the v

Externí odkaz: https://doaj.org/article/cfff92bc232541aab068dae26d28cf1b

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

Autor: Daniel Hess, Nicolas H. Thomä, Urs Wirth, Shaolian Zhou, Alexandra Stützer, Ling Li, Mahamadou Faty, Jonathan Aiwazian, Richard D. Bunker, Andreas Bauer, Nga Ly-Hartig, Kehao Zhao, Ho Man Chan, Justin Gu, Archana B. Prusty, Frank W. Schmitges, Heinz Gut, Jürg Müller, Gondichatnahalli M. Lingaraju, Tewis Bouwmeester, Ragna Sack, Wolfgang Fischle

Publikováno v: Molecular Cell

The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2 is modulated by histone modifications associated with transcriptionally active chromatin. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3db6ab295ba537d73bfbde35977a12
https://doi.org/10.1016/j.molcel.2011.03.025

Donation type and the effect of pre-transplant donor specific antibodies – Data from the Swiss Transplant Cohort Study

Autor: Olivier de Rougemont, Yun Deng, Lukas Frischknecht, Caroline Wehmeier, Jean Villard, Sylvie Ferrari-Lacraz, Déla Golshayan, Monique Gannagé, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson, the Swiss Transplant Cohort Study, Patrizia Amico, Andres Axel, John David Aubert, Vanessa Banz, Beckmann Sonja, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Pierre-Yves Bochud, Sanda Branca, Heiner Bucher, Thierry Carrel, Emmanuelle Catana, Yves Chalandon, Sabina De Geest, Olivier De Rougemont, Michael Dickenmann, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Nicola Franscini, Christian Garzoni, Paola Gasche Soccal, Christophe Gaudet, Nicolas Goossens, Karine Hadaya, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Michael Koller, Mirjam Laager, Bettina Laesser, Roger Lehmann, Alexander Leichtle, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Yves Martin, Michele Martinelli, Valérie McLin, Katell Mellac, Aurelia Mercay, Karin Mettler, Nicolas Mueller, Antonia Müller, Thomas Müller, Ulrike Müller-Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual, Klara Posfay-Barbe, Juliane Rick, Anne Rosselet, Simona Rossi, Silvia Rothlin, Frank Ruschitzka, Urs Schanz, Aurelia Schnyder, Macé Schuurmans, Thierry Sengstag, Federico Simonetta, Katharina Staufer, Susanne Stampf, Jürg Steiger, Guido Stirniman, Ueli Stürzinger, Christian Van Delden, Jean-Pierre Venetz, Julien Vionnet, Madeleine Wick, Markus Wilhlem, Patrick Yerly

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionThe type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. Many centers are, therefore, reluctant to perform donor specific antibody (DSA) positive transplantations in the setting of donati

Externí odkaz: https://doaj.org/article/4477ab4529c049ca9d56bbf4349cc853

Matrix-assisted laser desorption/ionization mass spectrometric quantification of the mu opioid receptor agonist DAMGO in ovine plasma

Autor: Jerry L. Lovelace, James F. Clapp, Thi M.-D. Nguyen, Hazel Szeto, Peter W. Schiller, Dominic M. Desiderio, Edward S. Umstot, Urs Wirth, Genevieve H. Fridland

Publikováno v: Journal of Mass Spectrometry. 35:725-733

The synthetic opioid peptide analog Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol (DAMGO), which is a mu opioid receptor-selective agonist, was quantified in ovine plasma samples with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c229f9996b6670fd21fcf32fa70c8200
https://doi.org/10.1002/1096-9888(200006)35:6<725::aid-jms1>3.0.co

Intact protein analysis by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry

Autor: Jennifer M. Campbell, Urs Wirth, Melanie Lin, Dieter Mueller

Publikováno v: Rapid communications in mass spectrometry : RCM. 17(16)

Direct tandem mass spectrometric (MS/MS) analysis of small, singly charged protein ions by tandem time-of-flight mass spectrometry (TOFMS) is demonstrated for proteins up to a molecular mass of 12 kDa. The MALDI-generated singly charged precursor ion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf29c4698e830bff50cf935310ac20db
https://pubmed.ncbi.nlm.nih.gov/12876680