Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Urs Baettig"'
Autor:
Giles Pergl-Wilson, Anna King, Julia Hatto, Henry Danahay, David Andrew Sandham, Mariana Oana Popa, Emily Stanley, Parmjit Bahra, Urs Baettig, Rebecca Butler, Brian Cox, Lightfoot Megan, Christopher J. Page, Alice Young, Paul J. Groot-Kormelink, Trixie Wagner, Swarupa Kulkarni, Glyn Hughes, Edward Charles Hall, David J. Rowlands, Lee Edwards, Atwood K. Cheung, Matthew Spendiff, Tom Sharp, Kamlesh Bala, Stephen Paul Collingwood, Hazel Watson, Julia Koehler, Oliver Ross Steward, Anne-Lise Glotin, Penny Wright, Cara E. Brocklehurst, Ulrike Glaenzel, Ian Nicholls, Richard I. Robinson, Roger J. Taylor, Catherine Howsham, Brian Everatt, Darren Le Grand, Hedaythul Choudhury, Gareth Williams, Emma Budd, Martin Gosling, Pamela Tranter
Publikováno v:
Journal of Medicinal Chemistry. 64:7241-7260
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke exposure has been shown to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795fc619db3aa5e70b7fe14aeddd53fe
https://doi.org/10.1021/acs.jmedchem.1c00343
https://doi.org/10.1021/acs.jmedchem.1c00343
Autor:
Julia Hatto, Oliver Ross Steward, Simon J. Watson, Anne-Marie D’Souza, Urs Baettig, Thomas Kuhnle, Richard I. Robinson, Eva Neumann, Benjamin Martin, Neil John Press, David Porter, Xinzhong Lai
Publikováno v:
Organic Process Research & Development. 19:1038-1043
The synthesis of a CXCR2 antagonist is presented, highlighting the process changes made from research synthesis to clinical supply. The target compound is the choline salt of a nonsymmetrical squaramide, and the modifications to the synthetic route w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a09aa635bcb0da90bd0be63cf97f38
https://doi.org/10.1021/acs.oprd.5b00072
https://doi.org/10.1021/acs.oprd.5b00072
Autor:
H Watson, Rosemary Sugar, Steve Collingwood, Nichola Smith, S Czarnecki, A. Schumacher, Ruth Lock, B Ethell, Chris Poll, Alice Young, Martin Gosling, Derek Paisley, J. Harris, T Faller, Kevin Coote, Gareth Williams, Urs Baettig, Morris Tweed, Henry Danahay, M Vyas, Juan R. Sabater, Paul J. Groot-Kormelink, William M. Abraham
Publikováno v:
British Journal of Pharmacology. 172:2814-2826
Background and Purpose Inhaled amiloride, a blocker of the epithelial sodium channel (ENaC), enhances mucociliary clearance (MCC) in cystic fibrosis (CF) patients. However, the dose of amiloride is limited by the mechanism-based side effect of hyperk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b36e56363558869ab210bdc358aac799
https://doi.org/10.1111/bph.13075
https://doi.org/10.1111/bph.13075
Autor:
Trevor John Howe, Paul Nicklin, Michelle Bradley, Angela Glen, Cecile Mocquet, Andrew Dunstan, Urs Baettig, Gurdip Bhalay, Juliet Leighton-Davies, Charles Owen, Elizabeth M. Rosethorne, Clive Mccarthy, Zarin Brown, Peter Gedeck, Mohammed Akhlaq, Alice Li, Thomas H. Keller, Birgit Albrecht, David Beer, Steven J. Charlton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6249-6252
A library of chemokine antagonists has been synthesized using a combination of solid and solution-phase chemistry. Structures of known chemokine antagonists were used to produce a pharmacophore which served to guide monomer selection. Several combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ff36805207f51c790022a08feabb7e
https://doi.org/10.1016/j.bmcl.2011.09.013
https://doi.org/10.1016/j.bmcl.2011.09.013
Autor:
Gurdip Bhalay, David Beer, Stephen Paul Collingwood, Sarah Craig, Nicholas James Devereux, Rowan Stringer, Sandra Haberthuer, Trevor John Howe, Angela Glen, Katharine L. Turner, Andrew Dunstan, Heinz E. Moser, Ruth Arnold, Mauro Zurini, Sylvie Gomez, Paul Nicklin, Simon J. Watson, Urs Baettig, Reto Naef, David Andrew Sandham, Stephen Jelfs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2587-2590
In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff42050bb668b5c21bf1217c7c6b8ce
https://doi.org/10.1016/s0960-894x(02)00480-8
https://doi.org/10.1016/s0960-894x(02)00480-8
Autor:
David C. Budd, David Bryan Harrison, Christopher Walker, Lucy Barker, Morris Tweed, Brian Everatt, Louise Bidlake, Rowan Stringer, Clive Aldcroft, Gurdip Bhalay, Catherine Leblanc, Emma Michelle Campbell, Urs Baettig, Simon J. Watson, Rachael Profit, Jennifer Willis, Gareth Williams, David Beer, Katharine L. Turner, Steven Whitebread, Zarin Brown, David Andrew Sandham, Gerald Dubois, Jodie Manini, Katy S Thompson, Brian Cox, Caroline Wilson
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6368f8bff73f2b501c96315902c5c8fa
https://pubmed.ncbi.nlm.nih.gov/17531480
https://pubmed.ncbi.nlm.nih.gov/17531480
Autor:
Peter D. Kane, Andrew Mitchelson, Colin Dell, Lyndon Nigel Brown, Sheila Garman, Morris Tweed, Alex Furzer, Garrick Smith, Mark Talbot, Clive Victor Walker, John Ambler, Diana Janus, Urs Baettig, Derek E. Brundish, Nicholas Wills, Xiaoling Cockcroft
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(14)
A series of monocyclic and bicyclic amino acids have been synthesised and incorporated into thrombin inhibitors based on CGH728, an analogue of the Mitsubishi compound MD805. Benzthiazolylalanine (Bta) was found to be a good non-polar substitute for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08f8ac4df35809e5380a0e81b468a5d
https://pubmed.ncbi.nlm.nih.gov/10915051
https://pubmed.ncbi.nlm.nih.gov/10915051
Publikováno v:
Survey of Anesthesiology. :171
The aim of this study was to evaluate the efficacy of tropisetron, a selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, versus placebo in the prevention of postoperative nausea and vomiting in patients undergoing general anesthesia for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6dde187961d4aa26a0afd8340864bc
https://doi.org/10.1097/00132586-199706000-00040
https://doi.org/10.1097/00132586-199706000-00040