Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Urs B, Hagemann"'
Autor:
Jenny Karlsson, Christoph A. Schatz, Antje M. Wengner, Stefanie Hammer, Arne Scholz, Alan Cuthbertson, Volker Wagner, Hartwig Hennekes, Vicki Jardine, Urs B. Hagemann
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
Targeted alpha therapy (TAT) is a promising approach for addressing unmet needs in oncology. Inherent properties make α-emitting radionuclides well suited to cancer therapy, including high linear energy transfer (LET), penetration range of 2–10 ce
Externí odkaz:
https://doaj.org/article/79d527281ca44a4b9b38e38914580781
Autor:
Pascale Lejeune, Véronique Cruciani, Axel Berg-Larsen, Andreas Schlicker, Anne Mobergslien, Lisa Bartnitzky, Sandra Berndt, Sabine Zitzmann-Kolbe, Claudia Kamfenkel, Stefan Stargard, Stefanie Hammer, Jennifer S Jørgensen, Malene Jackerott, Carsten H Nielsen, Christoph A Schatz, Hartwig Hennekes, Jenny Karlsson, Alan S Cuthbertson, Dominik Mumberg, Urs B Hagemann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/05e7344e8ce54a129a43af0ebbd6ec6f
Autor:
Cuthbertson, Jenny Karlsson, Urs B. Hagemann, Véronique Cruciani, Christoph A. Schatz, Derek Grant, Christine Ellingsen, Alexander Kristian, Shirin Katoozi, Dessislava Mihaylova, Steinar R. Uran, Mari Suominen, Roger M. Bjerke, Olav B. Ryan, Alan
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3419
Human epidermal growth factor receptor 2 (HER2) is overexpressed in 15–30% of breast cancers but has low expression in normal tissue, making it attractive for targeted alpha therapy (TAT). HER2-positive breast cancer typically metastasizes to bone,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::01b517f723aec72104e841d479d4b16e
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
The clinical efficacy of the first approved alpha pharmaceutical, Xofigo (radium-223 dichloride, 223RaCl2), has stimulated significant interest in the development of new alpha-particle emitting drugs in oncology. Unlike radium-223 (223Ra), the parent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e35ca4b99143e9db09cefc4dfb3643
https://doi.org/10.1158/1535-7163.c.6537598.v1
https://doi.org/10.1158/1535-7163.c.6537598.v1
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Blood samples from animals treated with vehicle and CD33-TTC, administered at the different dose levels, were taken at Day -1, Day 67 and Day 123. (A) White blood cell counts, expressed in 109/L. (B) Red blood cell counts, expressed in 1012/L.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e61add3f7aa0bbca94cc30520932a5
https://doi.org/10.1158/1535-7163.22504039.v1
https://doi.org/10.1158/1535-7163.22504039.v1
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361388845c3296c2208652b4c5f1bd17
https://doi.org/10.1158/1535-7163.22504033
https://doi.org/10.1158/1535-7163.22504033
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Thorium-227 is purified from actinium-227 (227Ac). Thorium-227 decays via its alpha- and beta-emitting daughters to stable nonradioactive 207Pb. The energy emitted at each decay step (in MeV) are summarized. When thorium-227 decays to radium-223, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f22fb266f9a191731b0ff6f2d053ec
https://doi.org/10.1158/1535-7163.22504045
https://doi.org/10.1158/1535-7163.22504045
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Isolated kidneys (A, B) and bone marrow (C, D) were co-stained with a CD33-specific antibody (A, C) and a CD45-specific antibody (B, D).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208fb2fc7d4c3690db8486abc7ecb072
https://doi.org/10.1158/1535-7163.22504036
https://doi.org/10.1158/1535-7163.22504036
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Binding of CD33 antibody and CD33 antibody chelator-conjugate to CD33-positive HL-60 cells by FACS staining in comparison to an isotype control. Bound antibodies were detected using secondary PE-labeled anti-human antibody. Median fluorescence intens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86281a6228865dcc88f6a91470e14717
https://doi.org/10.1158/1535-7163.22504042
https://doi.org/10.1158/1535-7163.22504042
Autor:
Mohamed E. Abazeed, Urs B. Hagemann, Gerhard Siemeister, Kristina Bannik, Priyanka Gopal, Brian D. Yard
Longer doubling times in cells most resistant to alpha-particle irradiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3542c0690d9328a43c716593c6b5fa1
https://doi.org/10.1158/0008-5472.22426477.v1
https://doi.org/10.1158/0008-5472.22426477.v1