Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Urs A. Ochsner"'
Autor:
Mary A. De Groote, Thale C. Jarvis, Christina Wong, James Graham, Teresa Hoang, Casey L. Young, Wendy Ribble, Joshua Day, Wei Li, Mary Jackson, Mercedes Gonzalez-Juarrero, Xicheng Sun, Urs A. Ochsner
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Mycobacteria remain an important problem worldwide, especially drug resistant human pathogens. Novel therapeutics are urgently needed to tackle both drug-resistant tuberculosis (TB) and difficult-to-treat infections with nontuberculous mycobacteria (
Externí odkaz:
https://doaj.org/article/ef2513c2756f449390c815c0714411b7
Publikováno v:
BioTechniques, Vol 56, Iss 3, Pp 125-133 (2014)
Protein diagnostic applications typically require pairs of analyte-specific reagents for capture and detection. We developed methods for the systematic isolation of slow off-rate modified aptamer (SOMAmer) reagents that bind to different epitopes and
Externí odkaz:
https://doaj.org/article/30cc35274a824a9185fa69bda93044c9
Autor:
Swati Patel, Moti Chapagain, Clifford Mason, Matthew Gingrich, Shruti Athale, Wendy Ribble, Teresa Hoang, Joshua Day, Xicheng Sun, Thale Jarvis, Urs A Ochsner, David Howe, Tawanda Gumbo
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:2876-2885
Background Listeriosis is an orphan disease, which is nevertheless fatal in immunocompromised people. CRS0540 is a novel PolC DNA polymerase inhibitor that has demonstrated good in vitro and in vivo activity against Listeria monocytogenes. Methods Ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f704cf2a22ef227e475e294a6177cba
https://doi.org/10.1093/jac/dkac269
https://doi.org/10.1093/jac/dkac269
Autor:
Urs A. Ochsner, Mary A. De Groote, Thale C. Jarvis, Hang Liu, Tessa Youmans, Teresa Hoang, Wendy Ribble, Joshua Day, Wei Li, Camron Pearce, Amanda Walz, Chandra M. Panthi, Binayak Rimal, Casey M. Stevens, Helen I. Zgurskaya, Mary Jackson, Diane Ordway, Mercedes Gonzalez-Juarrero, Xicheng Sun, Gyanu Lamichhane, Clifford Mason
Publikováno v:
Tuberculosis (Edinburgh, Scotland). 138
The benzothiazole amide CRS0393 demonstrated excellent in vitro activity against nontuberculous mycobacteria (NTM), including M. abscessus isolates from cystic fibrosis (CF) patients, with minimum inhibitory concentrations (MICs) of ≤0.03-0.5 μg/m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88ef490e2ea0c40194904ea50d13af3
https://pubmed.ncbi.nlm.nih.gov/36470124
https://pubmed.ncbi.nlm.nih.gov/36470124
Autor:
Thale C. Jarvis, Wendy Ribble, Xicheng Sun, Teresa Hoang, Elizabeth McFaddin, Joshua Day, Casey L. Young, Mary Ann DeGroote, Christina Wong, James E. Graham, Urs A. Ochsner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3177-3181
From a high throughput screening of commercially available libraries against nontuberculous mycobacteria and Mycobacterium tuberculosis, numerous hits were identified with moderate activity. Extensive medicinal chemistry optimization has led to a ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4185634cd19d14839191b939bb7e32c3
https://doi.org/10.1016/j.bmcl.2018.08.026
https://doi.org/10.1016/j.bmcl.2018.08.026
Autor:
Urs A. Ochsner, David Sterling, Nebojsa Janjic, Nicole A. Kruh-Garcia, Theresa M. Russell, Mary Ann De Groote, Louis S. Green, Thomas Hraha, Karen M. Dobos, Taylor Rice
Publikováno v:
Journal of Clinical Microbiology
Direct pathogen detection in blood to diagnose active tuberculosis (TB) has been difficult due to low levels of circulating antigens or due to the lack of specific, high-affinity binding reagents and reliable assays with adequate sensitivity. We soug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1d5f570c0dbb19cfd96fc769fdaf1a
https://doi.org/10.1128/jcm.00469-17
https://doi.org/10.1128/jcm.00469-17
Autor:
Mary Ann De Groote, Michael J. Higgins, Robert Belknap, Thomas Hraha, Michael L. Wilson, Nebojsa Janjic, Kirsten Wall, Randall Reves, Urs A. Ochsner, David Sterling
Publikováno v:
Journal of Clinical Microbiology. 55:391-402
The tests for diagnosing latent tuberculosis infection (LTBI) are limited by a poor predictive value for identifying people at the highest risk for progressing to active tuberculosis (TB) and have various sensitivities and specificities in different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1a31393cabaacd7bfa14edd1df4d982
https://doi.org/10.1128/jcm.01646-16
https://doi.org/10.1128/jcm.01646-16
Publikováno v:
Biochemistry. 58(46)
The mature forms of the TGF-β family members GDF-11 and GDF-8 are highly similar 25 kDa homodimers with 90% amino acid sequence identity and 99% similarity. Cross-reactivity of GDF-11 and GDF-8 binding reagents is common, making it difficult to attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9d0ff95de884988e5453ae865737c0
https://pubmed.ncbi.nlm.nih.gov/31638376
https://pubmed.ncbi.nlm.nih.gov/31638376
Autor:
Hal Galbraith, Barbara K Lomeli, Keith Z. Hazleton, Jacques Ravel, Ronald J. Evans, Blaire L. Osborn, Jared Schettler, Nebojsa Janjic, George A Saviolakis, Catherine A. Lozupone, Thale C. Jarvis, Urs A. Ochsner, Stacie J Bell, Wael El-Amin, Shahida Baqar
Publikováno v:
Antimicrobial Agents and Chemotherapy
CRS3123 is a novel small molecule that potently inhibits methionyl-tRNA synthetase of Clostridioides difficile, inhibiting C. difficile toxin production and spore formation. CRS3123 has been evaluated in a multiple-ascending-dose placebo-controlled p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ea0fd8e4858d178a353e6caaa8d1d1
https://pubmed.ncbi.nlm.nih.gov/31685472
https://pubmed.ncbi.nlm.nih.gov/31685472
Autor:
Thale C. Jarvis, Joshua Day, Wendy Ribble, Mary Jackson, Christina Wong, Xicheng Sun, Mary Ann De Groote, Casey L. Young, Urs A. Ochsner, Teresa Hoang, Mercedes Gonzalez-Juarrero, Wei Li, James E. Graham
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Frontiers in Microbiology
Frontiers in Microbiology, Vol 10 (2019)
Frontiers in Microbiology
Frontiers in Microbiology, Vol 10 (2019)
Mycobacteria remain an important problem worldwide, especially drug resistant human pathogens. Novel therapeutics are urgently needed to tackle both drug-resistant tuberculosis (TB) and difficult-to-treat infections with nontuberculous mycobacteria (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d45a258ef409ac593a89a1bdf054600
https://www.frontiersin.org/article/10.3389/fmicb.2018.02231/full
https://www.frontiersin.org/article/10.3389/fmicb.2018.02231/full