Zobrazeno 1 - 10 of 219 pro vyhledávání: '"Urs, Lüthi"'
1
Akademický článek
NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model
Autor: Patrick Sieber, Anny Schäfer, Raphael Lieberherr, Silvia L. Caimi, Urs Lüthi, Jesper Ryge, Jan H. Bergmann, François Le Goff, Manuel Stritt, Peter Blattmann, Bérengère Renault, Patrick Rammelt, Bruno Sempere, Diego Freti, Rolf Studer, Eric S. White, Magdalena Birker-Robaczewska, Maxime Boucher, Oliver Nayler
Publikováno v: JCI Insight, Vol 8, Iss 3 (2023)
In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic airspaces. Although these are characteristic features of IPF, kno
Externí odkaz: https://doaj.org/article/7c0ad56ad83d41d4b075e65592ee536c
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2
Akademický článek
Novel high-throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors.
Autor: Patrick Sieber, Anny Schäfer, Raphael Lieberherr, François Le Goff, Manuel Stritt, Richard W D Welford, John Gatfield, Oliver Peter, Oliver Nayler, Urs Lüthi
Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0207872 (2018)
Pathological features of pulmonary fibrosis include accumulation of myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α-smooth muscle actin (α-SMA)-expressing myofibroblasts that produce and secrete ECM
Externí odkaz: https://doaj.org/article/015179c2a49047e79610cca7f51ef289
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3
Akademický článek
The Screening Compound Collection: A Key Asset for Drug Discovery
Autor: Christoph Boss, Julien Hazemann, Thierry Kimmerlin, Modest von Korff, Urs Lüthi, Oliver Peter, Thomas Sander, Romain Siegrist
Publikováno v: CHIMIA, Vol 71, Iss 10 (2017)
In this case study on an essential instrument of modern drug discovery, we summarize our successful efforts in the last four years toward enhancing the Actelion screening compound collection. A key organizational step was the establishment of the Com
Externí odkaz: https://doaj.org/article/68ab4dea6eb6442e84b5acb76627fa1b
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8
A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFß receptor
Autor: Urs Regenass, Urs Lüthi, Simona Pavan, Sabine Ackerknecht, Tobias Fink, Manuel Stritt, Gerhard Christofori, Carina Lotz-Jenne, Matthias Wirth, François Lehembre, Ruben Bill, Nathalie Meyer-Schaller
Publikováno v: Oncotarget
An epithelial to mesenchymal transition (EMT) enables epithelial tumor cells to break out of the primary tumor mass and to metastasize. Understanding the molecular mechanisms driving EMT in more detail will provide important tools to interfere with t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0e8e64ae78d794a0ebb651fd20fb0f
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9
The Screening Compound Collection: A Key Asset for Drug Discovery
Autor: Thierry Kimmerlin, Thomas Sander, Julien Hazemann, Modest von Korff, Romain Siegrist, Christoph Boss, Oliver Peter, Urs Lüthi
Publikováno v: CHIMIA, Vol 71, Iss 10 (2017)
In this case study on an essential instrument of modern drug discovery, we summarize our successful efforts in the last four years toward enhancing the Actelion screening compound collection. A key organizational step was the establishment of the Com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b860ad8cfcfa9141d37e378cc6316e
https://pubmed.ncbi.nlm.nih.gov/29070412
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