Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Urpo, Lamminmäki"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Tracer antibodies, which are labelled with fluorescent or other type of reporter molecules, are widely employed in diagnostic immunoassays. Time-resolved fluorescence immunoassay (TRFIA), recognized as one of the most sensitive immunoassay t
Externí odkaz:
https://doaj.org/article/a83d4d541b8c4f58b36c53d1d34a0e41
Publikováno v:
BMC Biotechnology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Mammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as full-length IgG display with mammalian glycosylation and its inherent ability to select antibo
Externí odkaz:
https://doaj.org/article/f63f603231cc46329248587277987296
Autor:
Misba Khan, Md. Khirul Islam, Mafiur Rahman, Bert Dhondt, Ileana Quintero, Maija Puhka, Panu M. Jaakkola, Urpo Lamminmäki, Janne Leivo
Publikováno v:
Nano Select, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract Half of patients with renal cell carcinoma (RCC) develop metastases. New and noninvasive biomarkers are needed for the diagnosis of RCC. The study aims to develop an EV‐based assay for the detection of RCC using a highly sensitive nanopart
Externí odkaz:
https://doaj.org/article/e55164b7822c462caf1219c44a7c0720
Autor:
Md. Khirul Islam, Misba Khan, Kamlesh Gidwani, Kenneth W. Witwer, Urpo Lamminmäki, Janne Leivo
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be used to “target” EVs to spec
Externí odkaz:
https://doaj.org/article/00b473a79049445b8467c42916db3639
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Monoclonal antibodies (mAbs) and their fragments are widely used in therapeutics, diagnostics and basic research. Although display methods such as phage display offer high-throughput, affinities of individual antibodies need to be accurately
Externí odkaz:
https://doaj.org/article/2efd0e55bd7c4b86bf3baa6ed467d2bc
Autor:
Ida Alanko, Rebecca Sandberg, Eeva‐Christine Brockmann, Carla J. C. deHaas, Jos A. G. vanStrijp, Urpo Lamminmäki, Outi M. H. Salo‐Ahen
Publikováno v:
MicrobiologyOpen, Vol 12, Iss 4, Pp n/a-n/a (2023)
Abstract Staphylococcus aureus produces numerous virulence factors that manipulate the immune system, helping the bacteria avoid phagocytosis. In this study, we are investigating three immune evasion molecules called the staphylococcal superantigen
Externí odkaz:
https://doaj.org/article/6fdee959588f4c3087aa0871c5a809ad
Autor:
Eero Hietanen, Lav Tripathi, Eeva-Christine Brockmann, Pirjo Merilahti, Urpo Lamminmäki, Petri Susi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Human parechoviruses (PeVs) are common viruses that are associated with a variety of diseases from mild gastrointestinal and respiratory symptoms to severe central nervous system infections. Until now there has not been antibodies for visual
Externí odkaz:
https://doaj.org/article/6ce76c23cef349b9a3ce4462053803bb
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Mammalian display enables the selection of biophysically favorable antibodies from a large IgG antibody library displayed on the plasma membrane of mammalian cells. We constructed and validated a novel mammalian display platform utilizing the commerc
Externí odkaz:
https://doaj.org/article/b1bb56f0fbea421aa58ac67ff7fc5d88
Autor:
Md. Khirul Islam, Bert Dhondt, Parvez Syed, Misba Khan, Kamlesh Gidwani, Jason Webber, An Hendrix, Guido Jenster, Tarja Lamminen, Peter J. Boström, Kim Pettersson, Urpo Lamminmäki, Janne Leivo
Publikováno v:
Journal of Extracellular Biology, Vol 1, Iss 10, Pp n/a-n/a (2022)
Abstract Urinary extracellular vesicles (uEVs) are enriched with glycosylated proteins which have been extensively studied as putative biomarkers of urological cancers. Here, we characterized the glycosylation and integrin profile of EVs derived from
Externí odkaz:
https://doaj.org/article/1d91ebc06f174b25a384c8a485162385
Autor:
Priyanka Negi, Taina Heikkilä, Karoliina Vuorenpää, Emilia Tuunainen, Wail Nammas, Teemu Maaniitty, Juhani Knuuti, Jari Metso, Janita Lövgren, Matti Jauhiainen, Urpo Lamminmäki, Kim Pettersson, Antti Saraste
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveHigh-density lipoprotein (HDL) is a heterogeneous group of subpopulations differing in protein/lipid composition and in their anti-atherogenic function. There is a lack of assays that can target the functionality of HDL particles related to
Externí odkaz:
https://doaj.org/article/d8f5248c1ad345a0a3d4f9e782875e22