A roadmap for affordable genetic medicines.

Autor: Kliegman M; University of California, Berkeley, Innovative Genomics Institute, Berkeley, CA, USA. melinda.kliegman@berkeley.edu., Zaghlula M; University of California, Berkeley, Innovative Genomics Institute, Berkeley, CA, USA., Abrahamson S; University of California, Berkeley, Innovative Genomics Institute, Berkeley, CA, USA., Esensten JH; Sheba Medical Center, Ramat Gan, Israel., Wilson RC; University of California, Berkeley, Innovative Genomics Institute, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Urnov FD; University of California, Berkeley, Innovative Genomics Institute, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Doudna JA; University of California, Berkeley, Innovative Genomics Institute, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. doudna@berkeley.edu.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.

Publikováno v: Nature [Nature] 2024 Oct; Vol. 634 (8033), pp. 307-314. Date of Electronic Publication: 2024 Jul 17.

Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases.

Autor: Moehle EA; Sangamo BioSciences, Inc., Point Richmond Technology Center, 501 Canal Boulevard, Suite A100, Richmond, CA 94804, USA., Rock JM, Lee YL, Jouvenot Y, DeKelver RC, Gregory PD, Urnov FD, Holmes MC

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2007 Feb 27; Vol. 104 (9), pp. 3055-60. Date of Electronic Publication: 2007 Feb 20.

Imagine CRISPR cures.

Autor: Urnov FD; Professor, Molecular and Cell Biology Department, Scientific Director, Technology and Translation, Innovative Genomics Institute, UC Berkeley, 2151 Berkeley Way, Berkeley, CA 94720, USA. Electronic address: urnov@berkeley.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 Nov 03; Vol. 29 (11), pp. 3103-3106. Date of Electronic Publication: 2021 Oct 28.

Evidence generation and reproducibility in cell and gene therapy research: A call to action.

Autor: Abou-El-Enein M; Division of Medical Oncology, Department of Medicine and Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Joint USC/CHLA Cell Therapy Program, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA, USA., Angelis A; Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.; Department of Health Policy and LSE Health, London School of Economics and Political Science, London, UK., Appelbaum FR; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA., Andrews NC; Department of Pharmacology and Cancer Biology and Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Bates SE; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA., Bierman AS; Center for Evidence and Practice Improvement, Agency for Healthcare Research and Quality, Rockville, MD, USA., Brenner MK; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Cavazzana M; Biotherapy Department, Necker Children's Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.; Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Quest, INSERM, Paris, France., Caligiuri MA; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, CA, USA., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands.; University Medical Center Utrecht, Utrecht, the Netherlands., Cooke E; European Medicines Agency, Amsterdam, the Netherlands., Daley GQ; Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Dzau VJ; US National Academy of Medicine, Washington, DC, USA., Ellis LM; Department of Surgical Oncology and Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fineberg HV; Gordon and Betty Moore Foundation, Palo Alto, CA, USA., Goldstein LSB; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Gottschalk S; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA., Hamburg MA; American Association for the Advancement of Science (AAAS), Washington, DC, USA.; National Academy of Medicine, Washington, DC, USA., Ingber DE; Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, USA., Kohn DB; Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; The Eli & Edith Broad Center of Regenerative Medicine & Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA., Krainer AR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Maus MV; Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital Cancer Center, Charlestown, MA, USA., Marks P; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Mummery CL; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands., Pettigrew RI; ENMED, Colleges of Medicine and Engineering, Texas A&M University, Houston, TX, USA., Rutter JL; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Theory of Condensed Matter, Cavendish Laboratory, University of Cambridge, JJ Thomson Ave, Cambridge, UK., Terzic A; Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Urnov FD; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Williams DA; Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA., Wolchok JD; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Lawler M; Patrick G Johnston Centre for Cancer Research, Faculty of Medicine, Health and Life Sciences, Queen's University Belfast, Belfast, UK., Turtle CJ; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA., Bauer G; Institute for Regenerative Cures, University of California, Davis, Sacramento, CA, USA., Ioannidis JPA; Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, CA, USA.; Department of Epidemiology and Population Health and Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2021 Jul 21; Vol. 22, pp. 11-14. Date of Electronic Publication: 2021 Jul 21 (Print Publication: 2021).

Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus.

Autor: Ehrenberg AJ; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Moehle EA; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Brook CE; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Doudna Cate AH; University of California, Berkeley, California, United States of America., Witkowsky LB; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Sachdeva R; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Hirsh A; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Barry K; Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Hamilton JR; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Lin-Shiao E; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., McDevitt S; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Valentin-Alvarado L; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Letourneau KN; University of California, Berkeley, California, United States of America., Hunter L; University of California, Berkeley, California, United States of America., Keller A; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Pestal K; University of California, Berkeley, California, United States of America., Frankino PA; University of California, Berkeley, California, United States of America., Murley A; University of California, Berkeley, California, United States of America., Nandakumar D; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Stahl EC; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Tsuchida CA; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Gildea HK; University of California, Berkeley, California, United States of America., Murdock AG; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Hochstrasser ML; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., O'Brien E; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Ciling A; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Tsitsiklis A; University of California, Berkeley, California, United States of America., Worden K; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Dugast-Darzacq C; University of California, Berkeley, California, United States of America., Hays SG; University of California, Berkeley, California, United States of America., Barber CC; University of California, Berkeley, California, United States of America., McGarrigle R; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Lam EK; University of California, Berkeley, California, United States of America., Ensminger DC; University of California, Berkeley, California, United States of America., Bardet L; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Sherry C; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Harte A; University of California, Berkeley, California, United States of America.; University Health Services, University of California, Berkeley, California, United States of America., Nicolette G; University of California, Berkeley, California, United States of America.; University Health Services, University of California, Berkeley, California, United States of America., Giannikopoulos P; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Hockemeyer D; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America.; Chan Zuckerberg Biohub, San Francisco, California, United States of America., Petersen M; University of California, Berkeley, California, United States of America., Urnov FD; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Ringeisen BR; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America., Boots M; University of California, Berkeley, California, United States of America., Doudna JA; University of California, Berkeley, California, United States of America.; Innovative Genomics Institute, University of California, Berkeley, California, United States of America.; Howard Hughes Medical Institute, University of California, Berkeley, California, United States of America.

Publikováno v: PloS one [PLoS One] 2021 May 26; Vol. 16 (5), pp. e0251296. Date of Electronic Publication: 2021 May 26 (Print Publication: 2021).