Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Urmila M. Joshi"'
Publikováno v:
Biochemical Pharmacology. 35:3409-3412
Publikováno v:
International Journal of Biochemistry. 19:1029-1035
1. 1. Glutathione (GSH) and cysteine, added to the constituted incubation medium, rapidly disappeared from the medium in the presence of bovine serum albumin (BSA). The major portions of added GSH and cysteine were oxidized. Only a fraction was recov
Autor:
J.E. Thornburg, Urmila M. Joshi
Publikováno v:
Journal of Toxicology and Environmental Health. 19:337-344
The purpose of this study was to determine whether cimetidine exerts a protective effect against toxicity of organophosphate pesticides requiring metabolic activation in mice and rats. In both species, pretreatment with cimetidine (75 mg/kg/ip) 30 mi
Publikováno v:
Journal of Applied Toxicology. 9:367-375
Our previous studies indicated the involvement of some unidentified mechanisms, apart from the bioactivation phenomenon, in chlordecone (CD)-potentiated CCl4 hepatotoxicity and lethality. Recent studies revealed that hepatocellular regeneration is su
Autor:
Arvind K. Desai, Urmila M. Joshi
Publikováno v:
Ecotoxicology and Environmental Safety. 15:272-276
The purpose of the present investigation was to determine the effect of continuous exposure to the organophosphate monocrotophos at 2.5 ppm for over a period of 2 through 45 days on protein, RNA, and DNA contents and on 5′-nucleotidase activity in
Autor:
Robert A. Young, Prasada Rao S. Kodavanti, Urmila M. Joshi, Edward F. Meydrech, Harihara M. Mehendale
Publikováno v:
Toxicologic Pathology. 17:494-505
CCl4 is a hepatotoxic haloalkane, capable of producing hepatocellular fatty degeneration and centrilobular necrosis. Previous reports indicate induction of liver regeneration after 36-48 hr of CCl4 treatment, which is considered as a secondary effect
Publikováno v:
Biochimica et biophysica acta. 1004(3)
Lysosomal phospholipid storage disorder in lung tissue was observed during chronic treatment with amphiphilic amine drugs. The prevailing and widely accepted mechanism of phospholipidosis is that amphiphilic drugs bind to phospholipids and make the p
Publikováno v:
Toxicology and applied pharmacology. 96(2)
The purpose of the present investigation was to understand the acute effects of cigarette smoke on glutathione (GSH) metabolism and on utilization of external thiols by cigarette smoke-exposed, perfused rat and rabbit lungs. Most of the experiments w
Publikováno v:
Toxicology letters. 21(3)
The histological changes in the liver of Tilapia mossambica were observed after exposure to a sublethal level (2.5 ppm) of monocrotophos. The changes observed after 2 days of exposure were characterized by necrosis and vacuolation of hepatocytes. Fat
Autor:
Prasada Rao S. Kodavanti, Urmila M. Joshi, Harihara M. Mehendale, Andrea N. Bell, Robert A. Young
Publikováno v:
Archives of toxicology. 63(5)
Previous histomorphometric studies led us to hypothesize that suppression of hepatocellular regeneration and the repair of the hepatolobular architecture was involved besides bioactivation phenomenon in the progressive and irreversible phase of toxic