Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Urko del Castillo"'
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103536- (2022)
Summary: Ataxin-2 (Atx2) is a highly conserved RNA binding protein. Atx2 undergoes polyglutamine expansion leading to amyotrophic lateral sclerosis (ALS) or spinocerebellar ataxia type 2 (SCA2). However, the physiological functions of Atx2 in neurons
Externí odkaz:
https://doaj.org/article/4904c8d45acb41bbbcc86d151a6d0f4f
Publikováno v:
eLife, Vol 9 (2020)
Correct neuronal development requires tailored neurite outgrowth. Neurite outgrowth is driven in part by microtubule-sliding – the transport of microtubules along each other. We have recently demonstrated that a ‘mitotic’ kinesin-6 (Pavarotti i
Externí odkaz:
https://doaj.org/article/72ba507245d2416d8cb0bdf80baf3750
Publikováno v:
eLife, Vol 4 (2015)
In this study, we investigated how microtubule motors organize microtubules in Drosophila neurons. We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and minus-end-out microtubules push the tip of the axo
Externí odkaz:
https://doaj.org/article/2f1c7c4131f6428abafa3950b78e11a8
Autor:
William G. Stone, Urko del Castillo, Prashant V. Thakkar, Manish A. Shah, Paraskevi Giannakakou
Publikováno v:
Cancer Research. 83:1742-1742
Taxane-based chemotherapy is a first-line treatment for patients with Gastric Cancer (GC), however, many will not respond due to mechanisms of resistance. Recently, we reported the discovery of a novel truncated variant of the microtubule plus-end bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8a5b2422fe72e82e819f6328d01beed
https://doi.org/10.1158/1538-7445.am2023-1742
https://doi.org/10.1158/1538-7445.am2023-1742
Autor:
José Fernando Díaz, Yao Lu, Manish A. Shah, Dan L. Sackett, Katsuhiro Kita, Isabel Barasoain, Holly V. Goodson, Neel Madhukar, Olivier Elemento, Prashant V. Thakkar, Paraskevi Giannakakou, Arindam RoyChoudhury, Henrik Molina, Urko del Castillo, Giuseppe Galletti, Elena Vila Navarro
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dev Cell
instname
Dev Cell
73 p.-5 fig.-1 tab.-11 fig supl.-2 vid. supl.
Taxanes are widely used cancer chemotherapeutics. However, intrinsic resistance limits their efficacy without any actionable resistance mechanism. We have discovered a microtubule (MT) plus-end-bindi
Taxanes are widely used cancer chemotherapeutics. However, intrinsic resistance limits their efficacy without any actionable resistance mechanism. We have discovered a microtubule (MT) plus-end-bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a391ce7ea10498f1dc41227a96fb44e
http://hdl.handle.net/10261/256206
http://hdl.handle.net/10261/256206
Autor:
Prashant V. Thakkar, Katsuhiro Kita, Urko del Castillo, William G. Stone, Giuseppe Galletti, Neel Madhukar, Elena Vila Navarro, Elena Barasoain, Holly V. Goodson, Dan Sackett, José Fernando Díaz, Yao Lu, Arindam RoyChoudhury, Henrik Molina, Olivier Elemento, Manish A. Shah, Paraskevi Giannakakou
Publikováno v:
Cancer Research. 82:2623-2623
Despite its widespread use, the majority of patients with gastric cancer (GC) will not respond to taxane chemotherapy due to resistance mechanisms. Recently, we reported the discovery of a novel truncated variant of the microtubule plus-end binding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1008f32a87923ce71f29afa0e041e624
https://doi.org/10.1158/1538-7445.am2022-2623
https://doi.org/10.1158/1538-7445.am2022-2623
Publikováno v:
Proc Natl Acad Sci U S A
Microtubule polarity in axons and dendrites defines the direction of intracellular transport in neurons. Axons contain arrays of uniformly polarized microtubules with plus-ends facing the tips of the processes (plus-end-out), while dendrites contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71701dc96c7535889438dd338df43d24
https://pubmed.ncbi.nlm.nih.gov/32430325
https://pubmed.ncbi.nlm.nih.gov/32430325
Microtubule polarity in axons and dendrites defines the direction of intracellular transport in neurons. Axons contain arrays of uniformly polarized microtubules with plus-ends facing the tips of the processes (plus-end-out), while dendrites contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f46961eb6d659fe60fd79994b82554
https://doi.org/10.1101/2020.03.20.000364
https://doi.org/10.1101/2020.03.20.000364
Publikováno v:
Biophysical Journal. 115:1614-1624
Recent experimental studies of the role of microtubule sliding in neurite outgrowth suggested a qualitative model, according to which kinesin-1 motors push the minus-end-out microtubules against the cell membrane and generate the early cell processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02e1f94e2498697a4ca7e7d3c7c0520
https://doi.org/10.1016/j.bpj.2018.08.046
https://doi.org/10.1016/j.bpj.2018.08.046