Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Urjita H, Shah"'
Autor:
Nima Nassehi, Urjita H. Shah, Javier González-Maeso, Alaina M Jaster, Mario de la Fuente Revenga, Malgorzata Dukat, Prithvi Hemanth, Salvador Sierra
Publikováno v:
ACS Chem Neurosci
Known classic psychedelic serotonin 2A receptor (5-HT(2A)R) agonists retain a tryptamine or phenethylamine at their structural core. However, activation of the 5-HT(2A)R can be elicited by drugs lacking these fundamental scaffolds. Such is the case o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b4e9ea4667d67f7bbef71da417ace5
https://doi.org/10.1021/acschemneuro.0c00291
https://doi.org/10.1021/acschemneuro.0c00291
Autor:
Salvador Sierra, Karan H. Muchhala, Donald K. Jessup, Katherine M. Contreras, Urjita H. Shah, David L. Stevens, Jennifer Jimenez, Xiomara K. Cuno Lavilla, Mario de la Fuente Revenga, Kumiko M. Lippold, Shanwei Shen, Justin L. Poklis, Liya Y. Qiao, William L. Dewey, Hamid I. Akbarali, M. Imad Damaj, Javier González-Maeso
Publikováno v:
Neuropharmacology
Opioids are among the most effective analgesics and the mainstay of pain management. However, concerns about safety and abuse liability have challenged their widespread use by the medical community. Opioid-sparing therapies include drugs that in comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95feeb11babd86469a7334f6aa4413de
https://europepmc.org/articles/PMC8934299/
https://europepmc.org/articles/PMC8934299/
Autor:
Urjita H. Shah, Javier González-Maeso
Publikováno v:
ACS Chemical Neuroscience. 10:3068-3077
The serotonergic and glutamatergic neurotransmitter systems have both been implicated in the pathophysiology of schizophrenia, and there are multiple lines of evidence to demonstrate that they can interact in a functionally relevant manner. Particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aef705faeed653c5a40a7499f82450
https://doi.org/10.1021/acschemneuro.9b00044
https://doi.org/10.1021/acschemneuro.9b00044
Autor:
José L. Moreno, Urjita H. Shah, Richard A. Glennon, Javier González-Maeso, Supriya A Gaitonde, Malgorzata Dukat
Publikováno v:
ACS Chemical Neuroscience. 10:2318-2331
Pharmacophore models for 5-HT2A receptor antagonists consist of two aromatic/hydrophobic regions at a given distance from a basic amine. We have previously shown that both aromatic/hydrophobic moieties are unnecessary for binding or antagonist action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59c3d18b314fdb5bb80c017c1fbdd323
https://doi.org/10.1021/acschemneuro.8b00637
https://doi.org/10.1021/acschemneuro.8b00637
Autor:
Stuart C. Sealfon, Urjita H. Shah, Rudy Toneatti, Miguel Fribourg, Paul T. Arsenovic, Juan F. López-Giménez, Justin M. Saunders, Daniel E. Conway, Jong M. Shin, Deanna L. Benson, William G.M. Janssen, Javier González-Maeso, Carl R. Mayer
Publikováno v:
Sci Signal
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Membrane trafficking processes regulate G protein-coupled receptor (GPCR) activity. Although class A GPCRs are capable of activating G proteins in a monomeric form, they can also potentially assemble into functional GPCR heteromers. Here, we showed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42f6eacb2223840308c63fc49984472
http://hdl.handle.net/10261/227463
http://hdl.handle.net/10261/227463
Serotonin (5-HT) receptors play a prominent role in the central nervous system, as they modulate various neuropsychological processes. 5-HT receptors and transmitters are key drug targets for many brain disorders, including schizophrenia, mood disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54387f2be67b09a5cf74ab73957f713b
https://doi.org/10.1016/b978-0-444-64125-0.00011-6
https://doi.org/10.1016/b978-0-444-64125-0.00011-6
Autor:
Urjita H, Shah, Supriya A, Gaitonde, José L, Moreno, Richard A, Glennon, Małgorzata, Dukat, Javier, González-Maeso
Publikováno v:
ACS chemical neuroscience. 10(5)
Pharmacophore models for 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dfae65f8e588978ea5745b271ae2964c
https://pubmed.ncbi.nlm.nih.gov/30609893
https://pubmed.ncbi.nlm.nih.gov/30609893
Publikováno v:
Cell Chem Biol
G protein-coupled receptors (GPCRs) are critical mediators of cell signaling. Although capable of activating G proteins in a monomeric form, numerous studies reveal a possible association of class A GPCRs into dimers/oligomers. The relative location
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a1843870eeedac8b2664a4d0e37923
https://doi.org/10.1016/j.chembiol.2020.07.006
https://doi.org/10.1016/j.chembiol.2020.07.006