TERT Promoter Mutation as a Potential Predictive Biomarker in BCG-Treated Bladder Cancer Patients

Autor: Paula Soares, Lúcio Lara Santos, Rui Batista, Valdemar Máximo, Luís Lima, Vasco Pinto, João Vinagre, Joana Lyra

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 947 (2020)

Telomerase reverse transcriptase gene promoter (TERTp) mutations are recognized as one of the most frequent genetic events in bladder cancer (BC). No studies have focused on the relevance of TERTp mutations in the specific group of tumors treated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b230dd3e1baefd78f0fa5ee29fafc83
http://europepmc.org/articles/PMC7037401

Double Positive CD4+CD8+ T Cells Are Enriched in Urological Cancers and Favor T Helper-2 Polarization

Autor: Denise Nardelli-Haefliger, Ilaria Lucca, Massimo Valerio, Patrice Jichlinski, Sonia-Christina Rodrigues-Dias, Laurent Derré, Rodolfo Burruni, Florence Dartiguenave, Thomas Tawadros, Valérie Cesson, Perrine Bohner, Mathieu F. Chevalier

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2019, 10, ⟨10.3389/fimmu.2019.00622⟩
Frontiers in Immunology, Vol 10 (2019)
Frontiers in immunology, vol. 10, pp. 622

The immune system plays a central role in cancer development, showing both anti-tumor and pro-tumor activities depending on the immune cell subsets and the disease context. While CD8 T cells are associated with a favorable outcome in most cancers, on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f34716cc65e1b6de45583df3a05f67e
https://hal.archives-ouvertes.fr/hal-03031633/document

Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

Autor: Dylan Ferreira, Diana P. Sousa, Paula A. Videira, Ana Barbas, Carlos Novo, Lisete M. Silva, José Alexandre Ferreira, Angelina S. Palma, Wengang Chai, Liliana R. Loureiro, Carina Pereira, Viviana G. Correia, Carla B. Lopes, Lúcio Lara Santos, Chunxia Li, Luís Lima

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports

Incomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their applicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3108a72b878f321420e01421ee0e0d
https://doi.org/10.1038/s41598-018-30421-w

A case of pseudorenal failure - spontaneous rupture of the urinary bladder

Autor: Bourgeois, S, Decupere, M, Devriendt, D, Lesage, K, Van Moerkercke, W

A 64-year old woman was admitted to the hospital for severe abdominal pain and distension after gardening and chopping wood the day before. She had a medical history of superficial transitional cell carcinoma (TCC) of the urinary bladder and a laparo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3848::f43697c4aa526887e7f52e642219e7f8
https://hdl.handle.net/20.500.14017/4e4fd12c-b26f-4426-aea7-72cb6e54cb41

Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis

Autor: David J. McConkey, Giovanni Nitti, Neema Navai, Bogdan Czerniak, Tiewei Cheng, Colin P.N. Dinney, Debasish Sundi, Jonathan Melquist, Isuru Jayaratna, Sima P. Porten, Beat Roth, Charles C. Guo, Woonyoung Choi, Matthew F. Wszolek

Publikováno v: Roth, Beat; Jayaratna, Isuru; Sundi, Debasish; Cheng, Tiewei; Melquist, Jonathan; Choi, Woonyoung; Porten, Sima; Nitti, Giovanni; Navai, Neema; Wszolek, Matthew; Guo, Charles; Czerniak, Bogdan; McConkey, David; Dinney, Colin (2017). Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis. OncoTarget, 8(21), pp. 34205-34222. Impact Journals LLC 10.18632/oncotarget.11009
Oncotarget, vol. 8, no. 21, pp. 34205-34222
Oncotarget

Epithelial-to-mesenchymal transition (EMT) has been implicated in the progression of bladder cancer. To study its contribution to bladder cancer metastasis, we established new xenograft models derived from human bladder cancer cell lines utilizing an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f67ac40adab9d0a9896ed1530f170f