Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Uriel Trahtemberg"'
Persistence is key: unresolved immune dysfunction is lethal in both COVID-19 and non-COVID-19 sepsis
Autor:
Andy Y. An, Arjun Baghela, Peter Zhang, Reza Falsafi, Amy H. Lee, Uriel Trahtemberg, Andrew J. Baker, Claudia C. dos Santos, Robert E. W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 and non-COVID-19 pulmonary sepsis share pathophysiological, immunological, and clinical features, suggesting that severe COVID-19 is a form of viral sepsis. Our objective was to identify shared gene expression trajectories
Externí odkaz:
https://doaj.org/article/72fa51db86cf4ba7bc093529d5e48e74
Autor:
Andy Y. An, Arjun Baghela, Peter Zhang, Reza Falsafi, Amy H. Lee, Uriel Trahtemberg, Andrew J. Baker, Claudia C. dos Santos, Robert E. W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 and non-COVID-19 pulmonary sepsis share pathophysiological, immunological, and clinical features. To what extent they share mechanistically-based gene expression trajectories throughout hospitalization was unknown. Our obj
Externí odkaz:
https://doaj.org/article/7240eb0474994e7cbedec8b7e33d80b4
Autor:
Amanda Formosa, Erica Acton, Amy Lee, Paul Turgeon, Shehla Izhar, Pamela Plant, Jim N Tsoporis, Sabri Soussi, Uriel Trahtemberg, Andrew Baker, Claudia C Dos Santos
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0286871 (2023)
The COVID-19 pandemic has created an urgency to study the host gene response that leads to variable clinical presentations of the disease, particularly the critical illness response. miRNAs have been implicated in the mechanism of host immune dysregu
Externí odkaz:
https://doaj.org/article/857fda74732b4514a99496375f15f4de
Autor:
Dakota Gustafson, Michelle Ngai, Ruilin Wu, Huayun Hou, Alice Carvalhal Schoffel, Clara Erice, Serena Mandla, Filio Billia, Michael D. Wilson, Milica Radisic, Eddy Fan, Uriel Trahtemberg, Andrew Baker, Chris McIntosh, Chun-Po S. Fan, Claudia C. dos Santos, Kevin C. Kain, Kate Hanneman, Paaladinesh Thavendiranathan, Jason E. Fish, Kathryn L. Howe
Publikováno v:
EBioMedicine, Vol 78, Iss , Pp 103982- (2022)
Summary: Background: Endothelial cell (EC) activation, endotheliitis, vascular permeability, and thrombosis have been observed in patients with severe coronavirus disease 2019 (COVID-19), indicating that the vasculature is affected during the acute s
Externí odkaz:
https://doaj.org/article/46e3fc0616f94c3a9b413970ac0543e2
Autor:
Damber Thapa, Nakisa Samadi, Andrew Baker, Claudia dos Santos, Uriel Trahtemberg, Nima Tabatabaei
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1424 (2022)
While research suggests that COVID-19 vaccines are effective in producing anti-SARS-CoV-2 antibodies that reduce the risk of COVID-19 and its potentially severe complications, how long these antibodies persist after the infection/vaccination is unkno
Externí odkaz:
https://doaj.org/article/dc856666c98a4a55a4d78d1726ca1527
Autor:
Anat Gesser-Edelsburg, Ricky Cohen, Adva Mir Halavi, Mina Zemach, Peter Vernon van Heerden, Sigal Sviri, Shmuel Benenson, Uriel Trahtemberg, Efrat Orenbuch-Harroch, Lior Lowenstein, Dan Shteinberg, Asher Salmon, Allon Moses
Publikováno v:
Antimicrobial Resistance and Infection Control, Vol 7, Iss 1, Pp 1-10 (2018)
Abstract Background The literature is replete with attempts to design and promote customized guidelines to reduce infections during the care continuum. Paradoxically, these efforts sometimes result in gray areas where many staff members are unaware o
Externí odkaz:
https://doaj.org/article/bb538b05d5c248ba9e9ef8856d4bec36
Autor:
Uriel Trahtemberg, Dror Mevorach
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Inefficient and abnormal clearance of apoptotic cells (efferocytosis) contributes to systemic autoimmune disease in humans and mice, and inefficient chromosomal DNA degradation by DNAse II leads to systemic polyarthritis and a cytokine storm. By cont
Externí odkaz:
https://doaj.org/article/97697ce1494e44f3b049f0fb9f362a9a
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162984 (2016)
Human monocyte-derived dendritic cells (mdDCs) are versatile cells that are used widely for research and experimental therapies. Although different culture conditions can affect their characteristics, there are no known subpopulations. Since monocyte
Externí odkaz:
https://doaj.org/article/264e217c53ed4f39ae8abc4853f321f9
Autor:
Mizhir Atallah, Alon Krispin, Uriel Trahtemberg, Sandrine Ben-Hamron, Amir Grau, Inna Verbovetski, Dror Mevorach
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e29333 (2012)
Programmed cell death (PCD) is a fundamental mechanism in tissue and cell homeostasis. It was long suggested that apoptosis regulates the cell number in diverse cell populations; however no clear mechanism was shown. Neutrophils are the short-lived,
Externí odkaz:
https://doaj.org/article/eeb35066f79c4538a4d29d21b716797e
Autor:
Adi Tabib, Alon Krispin, Uriel Trahtemberg, Inna Verbovetski, Mario Lebendiker, Tsafi Danieli, Dror Mevorach
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6840 (2009)
In our previous study, we have found that thrombospondin-1 (TSP-1) is synthesized de novo upon monocyte and neutrophil apoptosis, leading to a phagocytic and tolerizing phenotype of dendritic cells (DC), even prior to DC-apoptotic cell interaction. I
Externí odkaz:
https://doaj.org/article/f6e97cec1b8e4f76b73c8b304b25d536